The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Patching vs Atropine to Treat Amblyopia in Children Aged 7 to 12 Years: A Randomized Trial
Open accessAbstract
OBJECTIVE: To compare patching with atropine eyedrops in the treatment of moderate amblyopia (visual acuity, 20/40-20/100) in children aged 7 to 12 years. METHODS: In a randomized, multicenter clinical trial, 193 children with amblyopia were assigned to receive weekend atropine or patching of the sound eye 2 hours per day. Main Outcome Measure Masked assessment of visual acuity in the amblyopic eye using the electronic Early Treatment Diabetic Retinopathy Study testing protocol at 17 weeks. RESULTS: At 17 weeks, visual acuity had improved from baseline by an average of 7.6 letters in the atropine group and 8.6 letters in the patching group. The mean difference between groups (patching - atropine) adjusted for baseline acuity was 1.2 letters (ends of complementary 1-sided 95% confidence intervals for noninferiority, -0.7, 3.1 letters). This difference met the prespecified definition for equivalence (confidence interval <5 letters). Visual acuity in the amblyopic eye was 20/25 or better in 15 participants in the atropine group (17%) and 20 in the patching group (24%; difference, 7%; 95% confidence interval, -3% to 17%). CONCLUSIONS: Treatment with atropine or patching led to similar degrees of improvement among 7- to 12-year-olds with moderate amblyopia. About 1 in 5 achieved visual acuity of 20/25 or better in the amblyopic eye. CLINICAL RELEVANCE: Atropine and patching achieve similar results among older children with unilateral amblyopia. TRIAL REGISTRATION: (clinicaltrials.gov) Identifier: NCT00315328.
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“In typically developing individuals, effectiveness of treatment diminishes after the age of 7 years, although there are substantial individual differences in response to treatment after that period (Scheiman et al., 2008).”
From Brain adaptation and alternative developmental trajectories (2015) · cites this paper as Scheiman et al., 2008
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A computerized method of visual acuity testing
Beck, R. W., Moke, P. S., Turpin, A. H., Ferris, F. L., SanGiovanni, J. P., Johnson, C. A., Birch, E. E., Chandler, D. L., Cox, T. A., Blair, R. C., et al. (2003) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01825-1 · Cited by 613
A Randomized Trial of Atropine vs Patching for Treatment of Moderate Amblyopia in Children
The Pediatric Eye Disease Investigator Group (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.3.268 · Cited by 569
Randomized Trial of Treatment of Amblyopia in Children Aged 7 to 17 Years
Scheiman, M. M., Hertle, R. W., Beck, R. W., Edwards, A. R., Birch, E. E., Cotter, S. A., Crouch, E. R., Cruz, O. A., Davitt, B. V., Donahue, S. P., et al. (2005) · Archives of Ophthalmology · doi:10.1001/archopht.123.4.437 · Cited by 489
A randomized trial of atropine regimens for treatment of moderate amblyopia in children
Repka, M. X. (2004) · Ophthalmology · doi:10.1016/j.ophtha.2004.04.032 · Cited by 249
Moke, P. S., Turpin, A. H., Beck, R. W., Holmes, J. M., Repka, M. X., Birch, E. E., Hertle, R. W., Kraker, R. T., Miller, J. M., & Johnson, C. A. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01256-9 · Cited by 226
Cole, S. R., Beck, R. W., Moke, P. S., Celano, M., Drews‐Botsch, C., Repka, M. X., Holmes, J. M., Birch, E. E., Kraker, R. T., & Kip, K. E. (2001) · Journal of American Association for Pediatric Ophthalmology and Strabismus · doi:10.1067/mpa.2001.117097 · Cited by 76
Hertle, R. W., Scheiman, M. M., Beck, R. W., Chandler, D. L., Bacal, D. A., Birch, E. E., Chu, R., Holmes, J. M., Klimek, D. L., Lee, K. A., et al. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.5.655 · Cited by 68
Cited by
Sorted by citations
Stereopsis and amblyopia: A mini-review
Levi, D. M., Knill, D. C., & Bavelier, D. (2015) · Vision Research · doi:10.1016/j.visres.2015.01.002 · Cited by 427
Perceptual learning as a potential treatment for amblyopia: A mini-review
Levi, D. M., & Li, R. W. (2009) · Vision Research · doi:10.1016/j.visres.2009.02.010 · Cited by 403
Effect of Age on Response to Amblyopia Treatment in Children
Holmes, J. M. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.179 · Cited by 367
“The protocols were (1) patching 2 hours per day with near or distance activities for children 3 to less than 7 years of age,(3) (2) treatment with atropine with or without a plano lens for children 3 to less than 7 years of age,(4) (3) treatment with atropine or patching 2 hours per day for children 7 to less than 13…”
Effect of a Binocular iPad Game vs Part-time Patching in Children Aged 5 to 12 Years With Amblyopia
Holmes, J. M., Manh, V. M., Lazar, E. L., Beck, R. W., Birch, E. E., Kraker, R. T., Crouch, E. R., Erzurum, S. A., Khuddus, N., Summers, A. I., et al. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2016.4262 · Cited by 217
Brain adaptation and alternative developmental trajectories
Johnson, M. H., Jones, E. J. H., & Gliga, T. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000073 · Cited by 213
Metadata
- Authors
- Pediatric Eye Disease Investigator Group
- Affiliations
- University of Ottawa (CA)
- Corresponding author
- Pediatric Eye Disease Investigator Group
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2008-12-08
- Volume
- 126
- Issue
- 12
- Pages
- 1634
- ISSN
- 0003-9950 (ISSN-L)
- PMC
- PMC2846774
- OpenAlex
- W97765374
- Cited by
- 182
- References
- 7
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 16 · 2021: 12 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (EY011751, U10EY011751, UG1EY011751)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Visual Impairment Studies
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- amblyopia, occlusion therapy, patching, atropine, atropine eye drops, visual acuity, children, unilateral amblyopia, non-inferiority, treatment equivalence
- MeSH terms
- Amblyopia, Atropine, Child, Female, Humans, Male, Mydriatics, Ophthalmic Solutions, Sensory Deprivation, Visual Acuity, Vision, Binocular, Treatment Outcome
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