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Cited by 177

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Malformations Caused by Drugs in Pregnancy

LENZ, W.·1966·Archives of Pediatrics & Adolescent Medicine
DOI 10.1001/archpedi.1966.02090110043001
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Abstract

UP TO 1961, only a few cases of malformations in man have been attributed to drugs, notably aminopterin (Thiersch, 1952;1and 1960;2Meltzer, 1956;3and Warkany et al, 19594), busulfan (Diamond et al 19605), androgens and progestogens (Wilkins, 19606), cortisone (Bongiovanni and McPadden, 19607), quinine (Grebe, 1952,8Uhlig, 1957;9and Windorfer, 195310), insulin (Wickes, 195411), and tolbutamide (Larsson and Sterky, 196012). A causal relationship has been well established only for aminopterin and for the androgenic and gestagenic hormones. A few cases of cleft palate following high doses of cortisone administered in early pregnancy are suggestive of a causative effect in view of similar results in animal experiments. A connection between quinine intake for artificial abortion and malformations has been assumed in selected cases. However, no unbiased study is available. The malformations attributed to quinine have not shown any

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Metadata

Authors
LENZ, W.
Venue
Archives of Pediatrics & Adolescent Medicine
Publisher
American Medical Association (AMA)
Published
1966-08-01
Volume
112
Issue
2
Pages
99
ISSN
1072-4710 (ISSN-L)
DOI
10.1001/archpedi.1966.02090110043001
OpenAlex
W1989496327
Cited by
177
References
0
FWCI
9.39
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Malformations Caused by Drugs in Pregnancy. https://app.cochat.ai/papers/10.1001/archpedi.1966.02090110043001
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LENZ, W. (1966). Malformations Caused by Drugs in Pregnancy. Archives of Pediatrics & Adolescent Medicine. https://doi.org/10.1001/archpedi.1966.02090110043001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.