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Cited by 371

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Cortisol Production in Depressive Illness: A Clinical and Biochemical Clarification

Sachar, Edward J.·1970·Archives of General Psychiatry

Abstract

THIS paper will attempt to clarify the relation of clinical features of depressive illness to the secretory activity of the adrenal cortex. The discovery that psychological stress stimulates the anterior pituitary-adrenocortical system1has led to considerable interest in studying the function of the adrenal cortex in patients with mental illnesses, including depressions. In a recent review paper,2Sachar pointed out that the extensive literature describing levels of adrenocortical hormones in depressed patients was quite inconsistent, with many reports suggesting elevated corticosteroid levels and other reports suggesting normal corticosteroid levels, some suggesting good correlation of severity of illness with adrenocortical indices, and others reporting poor correlations. It appeared that neglect of several significant control issues had contributed to the apparent diversity in findings. These necessary controls include eliminating all drugs which may interfere with the release of adrenocorticotropic hormone (ACTH), giving the patient enough time to get over

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Metadata

Authors
Sachar, E. J.
Venue
Archives of General Psychiatry
Published
1970-10-01
Volume
23
Issue
4
Pages
289
ISSN
0003-990X (ISSN-L)
OpenAlex
W2042169494
Cited by
371
References
1
FWCI
6.32
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cortisol Production in Depressive Illness: A Clinical and Biochemical Clarification. https://app.cochat.ai/papers/10.1001/archpsyc.1970.01750040001001
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Sachar, E. J. (1970). Cortisol Production in Depressive Illness: A Clinical and Biochemical Clarification. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1970.01750040001001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.