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Drug and Sociotherapy in the Aftercare of Schizophrenic Patients: II. Two-Year Relapse Rates
Abstract
We examined the effects of maintenance chlorpromazine and major role therapy (MRT) in forestalling the relapse of 374 schizophrenic patients recently discharged from the hospital. Chlorpromazine is significantly more effective than placebo in forestalling relapses (p<.001). By 24 months, 80% of placebo-treated patients have relapsed compared to 48% of those drug-treated. Further, although drug therapy is more effective than placebo in both sexes, the size of the difference is significantly greater for women than men (p<.01). There is no sex difference with placebo treatment. There is no significant effect of MRT during the entire treatment period. However, MRT does reduce relapses among those who survive in the community for six months after hospital discharge. These results were replicated at three clinics.
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Citations
Cited by
Leucht, S., Tardy, M., Komossa, K., Heres, S., Kissling, W., Salanti, G., & Davis, J. M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60239-6 · Cited by 931
A Controlled Trial of Social Intervention in the Families of Schizophrenic Patients
Leff, J., Kuipers, L., Berkowitz, R., Eberlein-Vries, R., & Sturgeon, D. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.141.2.121 · Cited by 869
Placebo interventions for all clinical conditions
Hróbjartsson, A., & Gøtzsche, P. C. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003974.pub3 · Cited by 777
Breier, A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810270051007 · Cited by 626
Freedman, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035458 · Cited by 587
Metadata
- Authors
- Hogarty, G. E.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1974-11-01
- Volume
- 31
- Issue
- 5
- Pages
- 603
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2070504779
- Cited by
- 573
- References
- 0
- FWCI
- 24.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hogarty, G. E. (1974). Drug and Sociotherapy in the Aftercare of Schizophrenic Patients: II. Two-Year Relapse Rates. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1974.01760170005001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
