The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neuroendocrine Regulation in Depression: I. Limbic System-Adrenocortical Dysfunction
Abstract
The regulation of hypothalamopituitary-adrenal (HPA) function in depressed patients was studied by a midnight dexamethasone suppression test. By using an observation period of 24 hours postadministration of dexamethasone, a graded series of abnormal test responses was identified. Depressed patients show abnormal early escape from suppression rather than absolute resistance to HPA suppression by dexamethasone. With increasing severity of depression, this escape occurs progressively more early on the day after administration of dexamethasone. These abnormalities were strongly related to the presence of HPA hyperactivity before dexamethasone was given. The essential disturbance of neuroendocrine regulation in depression is a failure of the normal brain inhibitory influence on the HPA system. This disinhibition of HPA activity suggests that there is an abnormal limbic system drive on the HPA axis in primary depressive illness.
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Citations
Cites
Characterization of the normal temporal pattern of plasma corticosteroid levels.
KRIEGER, D. T., ALLEN, W., RIZZO, F., & KRIEGER, H. P. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-32-2-266 · Cited by 549
Pituitary-adrenal function in severe depressive illness.
Butler, P. W. P., & Besser, G. M. (1968) · The Lancet · doi:10.1016/s0140-6736(68)91927-2 · Cited by 147
Cited by
Rosenthal, N. E. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790120076010 · Cited by 2,385
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
Self-citationKirschbaum, C., Kudielka, B. M., Gaab, J., Schommer, N. C., & Hellhammer, D. H. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00006 · Cited by 1,890
Sex differences in HPA axis responses to stress: a review
Kudielka, B. M., & Kirschbaum, C. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.009 · Cited by 1,624
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322
Metadata
- Authors
- Carroll, B. J.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1976-09-01
- Volume
- 33
- Issue
- 9
- Pages
- 1039
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2169824316
- Cited by
- 622
- References
- 2
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carroll, B. J. (1976). Neuroendocrine Regulation in Depression: I. Limbic System-Adrenocortical Dysfunction. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1976.01770090029002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
