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Cited by 168Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response

Post, Robert M.·1978·Archives of General Psychiatry
DOI 10.1001/archpsyc.1978.01770290091008
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Abstract

Piribedil, a compound that stimulates dopamine receptors in a relatively specific fashion, was administered to 11 hospitalized depressed patients. The dopamine agonist significantly decreased rapid eye movement (REM) sleep and percent REM sleep and increased REM latency. Piribedil decreased the probenecid-induced accumulation of the dopamine metabolite homovanillic acid (HVA) in CSF. A range of mild to moderate antidepressant effects was noted; one patient worsened and one developed recurrent manic episodes. The degree of improvement in depression was negatively correlated with pretreatment values of HVA in CSF (r = -.66, P less than .05). These data suggest that the heterogeneity of clinical response may be related to biological differences in depressed patients and that those with low initial dopaminergic function respond best to increased dopamine receptor stimulation.

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Crossref · 10.1001/archpsyc.1978.01770290091008

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Metadata

Authors
Post, R. M.
Corresponding author
Post, Robert M.
ORCID
Post, Robert M.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1978-05-01
Volume
35
Issue
5
Pages
609
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1978.01770290091008
OpenAlex
W1981234468
Cited by
168
References
65
Citations by year
2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
7.95
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
piribedil, dopamine agonists, depression, REM sleep, REM latency, homovanillic acid, cerebrospinal fluid, probenecid, antidepressant response, manic episodes, dopaminergic activity, individual differences in treatment response
MeSH terms
Adult, Bipolar Disorder, Clinical Trials as Topic, Depression, Double-Blind Method, Female, Homovanillic Acid, Humans, Male, Middle Aged, Phenylacetates, Piperazines, Piribedil, Psychiatric Status Rating Scales, Receptors, Dopamine, Sleep, REM

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