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Effects of Clonidine on Anxiety Disorders
Abstract
To examine the role of the noradrenergic system in anxiety disorders, 23 patients (nine with generalized anxiety disorders and 14 with panic disorders) were studied for four weeks with clonidine hydrochloride, a predominantly presynaptic noradrenergic agonist, and with placebo. A double-blind crossover design was used. The effect of clonidine was comparable in both anxiety disorders and superior to placebo in patients who tolerated the drug. The conditions of 17% of the patients became worse with the medication. The main effect of clonidine was a decrease of anxiety attacks and "psychic" symptoms. Somatic symptoms were least affected. The complexity of the results may be explained through the postsynaptic effects of clonidine, which in part neutralize its presynaptic nonadrenergic effects. It may also indicate disturbances in other neurotransmitter systems that are not affected by clonidine.
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Cites
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Cited by
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani, A., Murrough, J. W., Freire, R. C., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.595584 · Cited by 440
McNaughton, N., Kocsis, B., & Hajós, M. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee82e3 · Cited by 187
Fluyau, D., Revadigar, N., & Manobianco, B. E. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317753340 · Cited by 109
Psychiatric symptoms of noradrenergic dysfunction: A pathophysiological view
Yamamoto, K., Shinba, T., & Yoshii, M. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12126 · Cited by 88
The relationship between craving, anxiety, and other symptoms in opioid withdrawal
Swift, R. M., & Stout, R. L. (1992) · Journal of Substance Abuse · doi:10.1016/0899-3289(92)90024-r · Cited by 35
Metadata
- Authors
- Hoehn-Saric, R.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1981-11-01
- Volume
- 38
- Issue
- 11
- Pages
- 1278
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2058137137
- Cited by
- 225
- References
- 1
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
