The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Serotonin Uptake in Blood Platelets of Psychiatric Patients
Abstract
Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manic-depressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.
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Citations
Cites
The Biochemistry of Affective Disorders
Coppen, A. (1967) · British Journal of Psychiatry · doi:10.1192/bjp.113.504.1237 · Cited by 1,230
Cited by
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Four systems for emotion activation: Cognitive and noncognitive processes.
Izard, C. E. (1993) · Psychological Review · doi:10.1037//0033-295x.100.1.68 · Cited by 850
Cloning and expression of a functional serotonin transporter from rat brain
Blakely, R. D., Berson, H. E., Fremeau, R. T., Caron, M. G., Peek, M. M., Prince, H. K., & Bradley, C. C. (1991) · Nature · doi:10.1038/354066a0 · Cited by 831
Organization of the human serotonin transporter gene
Lesch, K. P., Balling, U., Gross, J., Strauss, K., Wolozin, B. L., Murphy, D. L., & Riederer, P. (1994) · Journal of Neural Transmission · doi:10.1007/bf01276434 · Cited by 629
From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters
Rudnick, G., & Clark, J. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90109-s · Cited by 469
Metadata
- Authors
- Meltzer, H. Y.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1981-12-01
- Volume
- 38
- Issue
- 12
- Pages
- 1322
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2132757457
- Cited by
- 233
- References
- 1
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meltzer, H. Y. (1981). Serotonin Uptake in Blood Platelets of Psychiatric Patients. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1981.01780370024002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
