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Familial Transmission of Depression and Alcoholism
Abstract
The familial transmission of major depression and alcoholism among probands who had depression and alcoholism was examined. Our findings indicated that depressives without alcoholism did not transmit alcoholism, and probands with depression and alcoholism tended to transmit both depression and alcoholism. This confirms the observation that depression and alcoholism are not manifestations of the same underlying disorder. An increased risk of anxiety disorders in the relatives of probands with alcoholism, which could specifically be attributed to the presence of alcoholism in addition to an anxiety disorder in the proband, was also observed. This suggested that the alcoholism in these probands may result from self-medication of anxiety symptoms. The results of this study underscore the importance of examining combinations of diagnoses in patients in decreasing the heterogeneity of diagnostic categories.
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Cited by
Bucholz, K. K., Cadoret, R., Cloninger, C. R., Dinwiddie, S. H., Hesselbrock, V. M., Nurnberger, J. I., Reich, T., Schmidt, I., & Schuckit, M. A. (1994) · Journal of Studies on Alcohol · doi:10.15288/jsa.1994.55.149 · Cited by 1,757
Comorbidity in Child Psychopathology: Concepts, Issues and Research Strategies
Caron, C., & Rutter, M. (1991) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1991.tb00350.x · Cited by 1,051
The comorbidity of depression and substance use disorders
Swendsen, J. (2000) · Clinical Psychology Review · doi:10.1016/s0272-7358(99)00026-4 · Cited by 632
The Dopamine D2 Receptor Locus as a Modifying Gene in Neuropsychiatric Disorders
Comings, D. E. (1991) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1991.03470130073032 · Cited by 587
An internalizing pathway to alcohol use and disorder.
Hussong, A. M., Jones, D. J., Stein, G. L., Baucom, D. H., & Boeding, S. (2011) · Psychology of Addictive Behaviors · doi:10.1037/a0024519 · Cited by 420
Metadata
- Authors
- Merikangas, K. R.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1985-04-01
- Volume
- 42
- Issue
- 4
- Pages
- 367
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2115621632
- Cited by
- 260
- References
- 0
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
