The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins
Abstract
Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and dizygotic twins were recorded. One group of twins was discordant for schizophrenia; the other group for manic depression or reactive psychosis. The data suggest that EMDs and at least some schizophrenias can be considered expressions of a single underlying trait that is transmitted by an autosomal dominant gene.
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Cites
Kety, S. S., Rosenthal, D., Wender, P. H., & Schulsinger, F. (1968) · Journal of Psychiatric Research · doi:10.1016/0022-3956(68)90026-5 · Cited by 704
Eye-Tracking Dysfunctions in Schizophrenic Patients and Their Relatives
Holzman, P. S. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760140005001 · Cited by 471
Self-citationEye-Tracking Patterns in Schizophrenia
Holzman, P. S., Proctor, L. R., & Hughes, D. W. (1973) · Science · doi:10.1126/science.181.4095.179 · Cited by 460
Self-citationTsuang, M. T., Winokur, G., & Crowe, R. R. (1980) · British Journal of Psychiatry · doi:10.1192/bjp.137.6.497 · Cited by 430
Diagnostic Approaches to Schizotypal Personality Disorder: A Historical Perspective
Kendler, K. S. (1985) · Schizophrenia Bulletin · doi:10.1093/schbul/11.4.538 · Cited by 276
Smooth Pursuit Eye Movements, Attention, and Schizophrenia
Holzman, P. S. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120019001 · Cited by 179
Self-citationBehavioral Precursors of Schizophrenia Spectrum: A Prospective Study
Parnas, J. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290060020005 · Cited by 176
Matthysse, S., Holzman, P. S., & Lange, K. (1986) · Journal of Psychiatric Research · doi:10.1016/0022-3956(86)90023-3 · Cited by 164
Self-citationEye-tracking performance in psychiatric patients.
Shagass, C., Amadeo, M., & Overton, D. A. (1974) · PubMed · Cited by 162
Heredity and Environment in the Functional Psychoses
(1967) · Elsevier eBooks · doi:10.1016/c2013-0-06737-0 · Cited by 159
Cited by
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.587 · Cited by 1,141
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917
The antisaccade: a review of basic research and clinical studies
Everling, S., & Fischer, B. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(98)00020-7 · Cited by 605
Developmental Processes in Schizophrenic Disorders: Longitudinal Studies of Vulnerability and Stress
Nuechterlein, K. H., Dawson, M. E., Gitlin, M., Ventura, J., Goldstein, M. J., Snyder, K. S., Yee, C. M., & Mintz, J. (1992) · Schizophrenia Bulletin · doi:10.1093/schbul/18.3.387 · Cited by 468
Leonard, S., Gault, J., Hopkins, J., Logel, J., Vianzon, R., Short, M., Drebing, C., Berger, R., Venn, D., Sirota, P., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1085 · Cited by 441
Metadata
- Authors
- Holzman, P. S.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1988-07-01
- Volume
- 45
- Issue
- 7
- Pages
- 641
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2046238075
- Cited by
- 269
- References
- 26
- FWCI
- 15.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins. https://app.cochat.ai/papers/10.1001/archpsyc.1988.01800310049006
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- Holzman, P. S. (1988). A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1988.01800310049006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
