The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Treatment of Obsessive-Compulsive Disorder With Clomipramine and Desipramine in Children and Adolescents: A Double-blind Crossover Comparison
Abstract
Forty-eight children and adolescents with severe primary obsessive-compulsive disorder completed a 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramine hydrochloride (mean dose [+/- SD], 153 +/- 55 mg/d). Clomipramine was clearly superior to desipramine in significantly reducing obsessive-compulsive symptoms. Age at onset, duration and severity of illness, type of symptom, and plasma drug concentrations did not predict clinical response to clomipramine. Sixty-four percent of patients who received clomipramine as their first active treatment showed at least some sign of relapse during desipramine treatment. We further document the specificity of the antiobsessional effect of clomipramine and the need for maintenance treatment.
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Cites
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Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Clomipramine Treatment of Obsessive-Compulsive Disorder: I. A Controlled Clinical Trial
Thorén, P. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780240079009 · Cited by 497
Clomipramine Treatment of Childhood Obsessive-Compulsive Disorder: A Double-blind Controlled Study
Flament, M. F. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790330057007 · Cited by 466
Obsessive-compulsive disorder and serotonin: Is there a connection?
Insel, T. R., Mueller, E. A., Alterman, I., Linnoila, M., & Murphy, D. L. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90176-3 · Cited by 343
Cited by
Baxter, L. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090009002 · Cited by 1,293
Katzman, M. A., Bleau, P., Blier, P., Chokka, P., Kjernisted, K., Van Ameringen, M., & the Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-s1-s1 · Cited by 1,090
Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Möller, H.-J., WFSBP TASK FORCE ON TREATMENT GUIDE, Bandelow, B., Zohar, J., Hollander, E., Kasper, S., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970802465807 · Cited by 854
Stein, D. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09620-4 · Cited by 352
GELLER, D. A., HOOG, S. L., HEILIGENSTEIN, J. H., RICARDI, R. K., TAMURA, R., KLUSZYNSKI, S., JACOBSON, J. G., & FLUOXETINE PEDIATRIC OCD STUDY TEAM (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200107000-00011 · Cited by 320
Metadata
- Authors
- Leonard, H. L.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1989-12-01
- Volume
- 46
- Issue
- 12
- Pages
- 1088
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2064632477
- Cited by
- 369
- References
- 4
- FWCI
- 22.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Treatment of Obsessive-Compulsive Disorder With Clomipramine and Desipramine in Children and Adolescents: A Double-blind Crossover Comparison. https://app.cochat.ai/papers/10.1001/archpsyc.1989.01810120030006
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- Leonard, H. L. (1989). Treatment of Obsessive-Compulsive Disorder With Clomipramine and Desipramine in Children and Adolescents: A Double-blind Crossover Comparison. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1989.01810120030006
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