Gilles de la Tourette Syndrome Is Not Linked to D2-Dopamine Receptor
Abstract
Gilles de la Tourette syndrome has an important genetic component; the pathophysiology of this disorder may involve the dopamine system. We tested a D2-dopamine receptor (locus DRD2, recognized by probe hD2G1) for genetic linkage with Gilles de la Tourette syndrome. Using a genetic linkage map of the region of DRD2 on the long arm of chromosome 11 and restriction fragment length polymorphism data from a total of four markers (DRD2 itself, D11S84, D11S29, and PBGD), we were able to exclude linkage of this candidate gene and Gilles de la Tourette syndrome in two extended kindreds segregating for Gilles de la Tourette syndrome. This rules out causation of Gilles de la Tourette syndrome by mutation in DRD2 in the kindreds studied under the genetic assumptions we employed; use of the map and multipoint linkage analyses also allowed us to exclude a Gilles de la Tourette syndrome susceptibility locus from a larger genetic region.
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Variants in the DA receptor gene DRD2 have been associated with genetic risk for TS, but this finding is not consistent.
“Variants in the DA receptor gene DRD2 have also been associated with genetic risk for TS [626-628], but this finding is not consistent [629-633].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [631]
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References 37 · Cited by 72
- Authors
- Gelernter, J.
- Affiliations
- Yale University (US)
- Corresponding author
- Gelernter, Joel
- ORCID
- Gelernter, Joel
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1990-11-01
- Volume
- 47
- Issue
- 11
- Pages
- 1073
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2063035908
- Cited by
- 72
- References
- 37
- Citations by year
- 2020: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH39 239, MH30929)
- National Institute of Neurological Disorders and Stroke (R01NS016648, NS-16648)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Tourette syndrome, dopamine D2 receptor, DRD2 gene, genetic linkage, chromosome 11, dopaminergic system, candidate genes, multipoint linkage analysis, restriction fragment length polymorphism, genetic susceptibility loci, kindred
- MeSH terms
- Chromosome Mapping, Chromosomes, Human, Pair 11, Genetic Markers, Tourette Syndrome, Humans, Genetic Linkage, Lod Score, Mutation, Pedigree, Receptors, Dopamine, Polymorphism, Restriction Fragment Length
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