The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Altered Serotonin Activity in Anorexia Nervosa After Long-term Weight Restoration: Does Elevated Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Level Correlate With Rigid and Obsessive Behavior?
Abstract
To avoid the confounding influences of malnutrition or weight loss, we studied patients with anorexia nervosa at normal weight and stable dietary intake. Compared with 15 controls, 17 long-term weight-restored anorectic subjects had elevated concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid, the major serotonin metabolite, whereas levels of cerebrospinal fluid homovanillic acid, the major dopamine metabolite, were normal. Elevated levels of cerebrospinal fluid 5-hydroxyindoleacetic acid may indicate increased serotonin activity. Such activity could contribute to pathological feeding behavior. Most importantly, this study raises the question as to whether increased cerebrospinal fluid 5-hydroxyindoleacetic acid levels are associated with overly inhibited, anxious, or obsessive traits.
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Cites
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Cited by
Jacobi, C., Hayward, C., de Zwaan, M., Kraemer, H. C., & Agras, W. S. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.19 · Cited by 1,429
New insights into symptoms and neurocircuit function of anorexia nervosa
Kaye, W. H., Fudge, J. L., & Paulus, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2682 · Cited by 843
Self-citationCulbert, K. M., Racine, S. E., & Klump, K. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12441 · Cited by 642
Neurobiology of anorexia and bulimia nervosa
Kaye, W. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.037 · Cited by 625
Self-citationStrober, M., Freeman, R., Lampert, C., Diamond, J., & Kaye, W. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.393 · Cited by 560
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Metadata
- Authors
- Kaye, W. H.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1991-06-01
- Volume
- 48
- Issue
- 6
- Pages
- 556
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2047326118
- Cited by
- 279
- References
- 64
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Altered Serotonin Activity in Anorexia Nervosa After Long-term Weight Restoration: Does Elevated Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Level Correlate With Rigid and Obsessive Behavior? https://app.cochat.ai/papers/10.1001/archpsyc.1991.01810300068010
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- Kaye, W. H. (1991). Altered Serotonin Activity in Anorexia Nervosa After Long-term Weight Restoration: Does Elevated Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Level Correlate With Rigid and Obsessive Behavior? Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1991.01810300068010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
