Progressive Brain Volume Changes and the Clinical Course of Schizophrenia in Men: A Longitudinal Magnetic Resonance Imaging Study
Abstract
sion in right frontal sulci, left lateral ventricle, and bilateral prefrontal and posterior superior temporal sulci. Faster rates of frontal sulcal expansion were related to greater BPRS total and positive symptom scores and longer time hospitalized. Prefrontal gray matter decline and sulcal expansion were associated with greater BPRS negative symptom scores and longer time hospitalized. Temporal lobe gray matter decline was associated with greater BPRS total and negative symptom scores. Conclusions: This controlled study revealed that patients with chronic schizophrenia exhibited accelerated frontotemporal cortical gray matter decline and cortical sulcal and lateral ventricular expansion. Further, greater clinical severity was associated with faster rates of frontotemporal brain volume changes. These observations are consistent with a progressive pathophysiological process but need to be replicated in a larger sample.
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The superior temporal gyrus diminishes in size over time in those with a diagnosis of schizophrenia, specifically related to positive symptoms.
“Mathalon et al. (2001) have shown that the STG diminishes in size over time in those with a diagnosis of schizophrenia, specifically related to positive symptoms in schizophrenia”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Mathalon et al., 2001
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References 88
- Authors
- Mathalon, D. H., Sullivan, E. V., Lim, K. O., & Pfefferbaum, A.
- Affiliations
- Stanford Medicine (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2001-02-01
- Volume
- 58
- Issue
- 2
- Pages
- 148
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1496865392
- Cited by
- 0
- References
- 88
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA-05965)
- National Institute of Mental Health (MH-30854, MH 58007)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- schizophrenia, brain volume changes, frontotemporal cortex, negative symptoms, positive symptoms, clinical severity, men, chronic schizophrenia, length of hospital stay
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