The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression.
Abstract
BACKGROUND: Evidence suggests that serotonin transporter gene promoter polymorphism (5HTTLPR)-dependent low transcriptional activity of the human serotonin transporter gene may be a genetic susceptibility factor for depression. We studied the behavioral responses to tryptophan depletion (TD) in healthy women with and without a first-degree family history of depression and examined the relationship to 5HTTLPR alleles. METHODS: Twenty-four healthy women with a negative family history of depression and 21 women with a positive family history of depression were genotyped for the polymorphism of the 5HTTLPR and then entered a double-blind, placebo-controlled, randomized crossover TD study. The effects of these interventions were assessed with measures of depression and plasma tryptophan levels. RESULTS: The TD induced a robust decrease of plasma tryptophan levels in all women irrespective of family history of depression or 5HTTLPR genotypes. The s/s genotype of the 5HTTLPR was associated with an increased risk of developing depressive symptoms during TD irrespective of family history. In contrast, individuals with the l/l genotype did not develop depressive symptoms, irrespective of family history. Finally, s/l subjects without family history showed a mood response that was intermediate between the s/s and l/l subjects, while s/l subjects with a family history of depression showed the same depressiogenic effect of TD as seen in the s/s subjects. CONCLUSIONS: The results of the present study suggest that the s-allele of the 5HTTLPR and a positive family history of depression are additive risk factors for the development of depression during TD.
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“The stronger dependence on serotonin in at-risk subjects would explain why only they are sensitive to the mood effects of tryptophan depletion [34], and why individuals with a polymorphism in the serotonin transporter gene that reduces serotonin uptake are more liable to develop mood disturbance, especially following serotonin depletion [41], [42].”
From Bonsai trees in your head: how the pavlovian system sculpts goal-directed choices by pruning decision trees (2012) · cites this paper as [42]
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Cites
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
(1997) · American Psychiatric Press eBooks · Cited by 3,056
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207
ON THE METHODS AND THEORY OF RELIABILITY
Bartko, J. J., & Carpenter, W. T. (1976) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197611000-00003 · Cited by 1,302
THE TRIDIMENSIONAL PERSONALITY QUESTIONNAIRE: U.S. NORMATIVE DATA
Cloninger, C. R., Przybeck, T. R., & Švrakić, D. M. (1991) · Psychological Reports · doi:10.2466/pr0.1991.69.3.1047 · Cited by 1,034
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
Owens, M. J., & Nemeroff, C. B. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.288 · Cited by 932
Differences between males and females in rates of serotonin synthesis in human brain
Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., & Dikšić, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5308 · Cited by 911
Ramamoorthy, S., Bauman, A. L., Moore, K. R., Han, H. J., Yang‐Feng, T. L., Chang, A. S., Ganapathy, V., & Blakely, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2542 · Cited by 877
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The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Youth Suicide Risk and Preventive Interventions: A Review of the Past 10 Years
Gould, M. S., Greenberg, T., Velting, D. M., & Shaffer, D. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046821.95464.cf · Cited by 1,264
The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160
Discovering Endophenotypes for Major Depression
Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068
Metadata
- Authors
- Neumeister, A., Konstantinidis, A., Stastny, J., Schwarz, M. J., Vitouch, O., Willeit, M., Praschak-Rieder, N., Zach, J., de Zwaan, M., Bondy, B., Ackenheil, M., & Kasper, S.
- Affiliations
- National Institutes of Health (US)
- Max Planck Society (DE)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2002-07-01
- Volume
- 59
- Issue
- 7
- Pages
- 613
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2111173241
- Cited by
- 223
- References
- 78
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 8 · 2012: 10
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- 5-HTTLPR, serotonin transporter gene, tryptophan depletion, family history of depression, genetic susceptibility to depression, S-alleles, depressive symptoms, women, gene-environment interaction
- MeSH terms
- Adult, Carrier Proteins, Depressive Disorder, Family, Female, Genotype, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Placebos, Polymorphism, Genetic, Promoter Regions, Genetic, Risk Factors, Serotonin, Tryptophan, Genetic Predisposition to Disease, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins
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