Relationships Among Plasma Dehydroepiandrosterone Sulfate and CortisolLevels, Symptoms of Dissociation, and Objective Performance in Humans Exposedto Acute Stress
Abstract
CONTEXT: Recently, a growing body of research has provided evidence that dehydroepiandrosterone sulfate (DHEA-S) is involved in an organism's response to stress and that it may provide beneficial behavioral and neurotrophic effects. OBJECTIVE: To investigate plasma DHEA-S and cortisol levels, psychological symptoms of dissociation, and military performance. DESIGN: Prospective study. SETTING AND PARTICIPANTS: Twenty-five healthy subjects enrolled in military survival school. RESULTS: The DHEA-S-cortisol ratios during stress were significantly higher in subjects who reported fewer symptoms of dissociation and exhibited superior military performance. CONCLUSIONS: These data provide prospective, empirical evidence that the DHEA-S level is increased by acute stress in healthy humans and that the DHEA-S-cortisol ratio may index the degree to which an individual is buffered against the negative effects of stress.
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DHEA may promote an adaptive response to stress by antagonizing the effects of cortisol.
“As such, it has been suggested that DHEA may promote an adaptive response to stress by antagonizing the effects of cortisol (Morgan et al., 2004).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Morgan et al., 2004
DHEA is secreted synchronously with cortisol in response to ACTH and is elevated in response to psychosocial stress.
“DHEA is secreted synchronously with cortisol in response to ACTH, and has been shown to be elevated in response to psychosocial stress (Izawa et al., 2008; Lennartsson et al., 2012; Morgan et al., 2004).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Morgan et al., 2004
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References 55 · Cited by 304
- Authors
- Morgan, C. A., Southwick, S., Hazlett, G., Rasmusson, A., Hoyt, G., Zimolo, Z., & Charney, D.
- Affiliations
- VA Connecticut Healthcare System (US)
- United States Army (US)
- Yale University (US)
- National Institutes of Health (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2004-08-01
- Volume
- 61
- Issue
- 8
- Pages
- 819
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2001183947
- Cited by
- 304
- References
- 55
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 11 · 2023: 7 · 2022: 15 · 2021: 13 · 2020: 11 · 2019: 16 · 2018: 16 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 25 · 2013: 18 · 2012: 18
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- dehydroepiandrosterone sulfate, cortisol, dissociation, acute stress, stress buffering, military performance, survival training, stress response
- MeSH terms
- Acute Disease, Adult, Dissociative Disorders, Humans, Hydrocortisone, Life Change Events, Male, Military Personnel, Problem Solving, Prospective Studies, Psychiatric Status Rating Scales, Regression Analysis, Saliva, Stress, Psychological, Task Performance and Analysis, Dehydroepiandrosterone Sulfate
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