The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Family-Focused Treatment for Adolescents With Bipolar Disorder: Results of a 2-Year Randomized Trial
Open accessAbstract
CONTEXT: Family interventions have been found to hasten episode recovery and delay recurrences among adults with bipolar disorder. OBJECTIVE: To examine the benefits of family-focused treatment for adolescents (FFT-A) and pharmacotherapy in the 2-year course of adolescent bipolar disorder. DESIGN: Two-site outpatient randomized controlled trial with 2-year follow-up. PATIENTS: A referred sample of 58 adolescents (mean [SD] age, 14.5 [1.6] years) with bipolar I (n = 38), II (n = 6), or not otherwise specified disorder (n = 14) with a mood episode in the prior 3 months. INTERVENTIONS: Patients were randomly assigned to FFT-A and protocol pharmacotherapy (n = 30) or enhanced care (EC) and protocol pharmacotherapy (n = 28). The FFT-A consisted of 21 sessions in 9 months of psychoeducation, communication training, and problem-solving skills training. The EC consisted of 3 family sessions focused on relapse prevention. MAIN OUTCOME MEASURES: Independent "blind" evaluators assessed patients every 3 to 6 months for 2 years. Outcomes included time to recovery from the index episode, time to recurrence, weeks in episode or remission, and mood symptom severity scores. RESULTS: Analyses were by intent to treat. Rates of 2-year study completion did not differ across the FFT-A (60.0%) and EC conditions (64.3%). Although there were no group differences in rates of recovery from the index episode, patients in FFT-A recovered from their baseline depressive symptoms faster than patients in EC (hazard ratio, 1.85; 95% confidence interval, 1.04-3.29; P = .04). The groups did not differ in time to recurrence of depression or mania, but patients in FFT-A spent fewer weeks in depressive episodes and had a more favorable trajectory of depression symptoms for 2 years. CONCLUSIONS: Family-focused therapy is effective in combination with pharmacotherapy in stabilizing bipolar depressive symptoms among adolescents. To establish full recovery, FFT-A may need to be supplemented with systematic care interventions effective for mania symptoms.
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Cites
A Children's Global Assessment Scale (CGAS)
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Self-citationDialectical Behavior Therapy for Adolescents With Bipolar Disorder: A 1-Year Open Trial
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Self-citationEvaluating Therapist Competency and Adherence to Behavioral Family Management with Bipolar Patients
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Grande, I., Berk, M., Birmaher, B., & Vieta, E. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00241-x · Cited by 1,710
Self-citationGoodwin, G., Haddad, P., Ferrier, I., Aronson, J., Barnes, T., Cipriani, A., Coghill, D., Fazel, S., Geddes, Jr., Grunze, H., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636545 · Cited by 1,309
Self-citationVieta, E., Berk, M., Schulze, T. G., Carvalho, A. F., Suppes, T., Calabrese, J. R., Gao, K., Miskowiak, K. W., & Grande, I. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.8 · Cited by 891
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Self-citationAdjunctive Psychotherapy for Bipolar Disorder: State of the Evidence
Miklowitz, D. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08040488 · Cited by 311
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Metadata
- Authors
- Miklowitz, D. J., Axelson, D. A., Birmaher, B., George, E. L., Taylor, D. O., Schneck, C. D., Beresford, C. A., Dickinson, L. M., Craighead, W. E., & Brent, D. A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2008-09-01
- Volume
- 65
- Issue
- 9
- Pages
- 1053
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2160342443
- Cited by
- 261
- References
- 9
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- green
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