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Localization of Atherosclerosis: Role of Hemodynamics
Abstract
Atherosclerosis is a chronic disease attributed to risk factors that are systemic in nature. Yet the lesions involved do not occur in random fashion. The coronary arteries, the major branches of the aortic arch, and the abdominal aorta and its visceral and major lower extremity branches are particularly susceptible sites. Hemodynamic forces interacting with an active vascular endothelium are responsible for localizing lesions in a nonrandom pattern of distribution. Shear stress and cyclic circumferential strain are the predominant forces that have been characterized. The modification of endothelial cell structure and function by these mechanical forces sheds insight into the vasculature's propensity for atherogenesis.
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Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Cells in focus: endothelial cell
Sumpio, B. E., Timothy Riley, J., & Dardik, A. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00075-4 · Cited by 531
Chen, M., Masaki, T., & Sawamura, T. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00236-x · Cited by 375
Arterial Wall Shear Stress: Observations from the Bench to the Bedside
Paszkowiak, J. J., & Dardik, A. (2003) · Vascular and Endovascular Surgery · doi:10.1177/153857440303700107 · Cited by 344
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
Yun, S., Budatha, M., Dahlman, J. E., Coon, B. G., Cameron, R. T., Langer, R., Anderson, D. G., Baillie, G., & Schwartz, M. A. (2016) · Nature Cell Biology · doi:10.1038/ncb3405 · Cited by 96
Metadata
- Authors
- Frangos, S. G.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1999-10-01
- Volume
- 134
- Issue
- 10
- Pages
- 1142
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2038542977
- Cited by
- 190
- References
- 0
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- closed
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