The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
STUDIES ON PROSTATIC CANCER: II. THE EFFECTS OF CASTRATION ON ADVANCED CARCINOMA OF THE PROSTATE GLAND
Abstract
The thesis of this work may be briefly summarized. In many instances a malignant prostatic tumor is an overgrowth of adult epithelial cells. All known types of adult prostatic epithelium undergo atrophy when androgenic hormones are greatly reduced in amount or inactivated. In this paper evidence is presented that significant improvement often occurs in the clinical condition of patients with far advanced cancer of the prostate after they have been subjected to castration. Conversely, the symptoms are aggravated when androgens are injected. We believe that this work provides a new concept of prostatic carcinoma. The evidence that prostatic carcinoma is often composed of an adult type of epithelium derives from a study of such tissue with respect to the phosphatase which manifests optimum activity atpH5. An important advance in the technic of investigation of the prostate gland was made by Kutscher and Wolbergs,1who found that
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Cites
Huggins, C., & Hodges, C. V. (2002) · Journal of Urology · doi:10.1016/s0022-5347(05)64820-3 · Cited by 3,855
Self-citationMicrotechnical Demonstration of Phosphatase in Tissue Sections.
Gomori, G. (1939) · Experimental Biology and Medicine · doi:10.3181/00379727-42-10786 · Cited by 741
Gutman, A. B., & Gutman, E. B. (1938) · Journal of Clinical Investigation · doi:10.1172/jci100974 · Cited by 553
QUANTITATIVE STUDIES OF PROSTATIC SECRETION
Huggins, C., & Clark, P. J. (1940) · Journal of Experimental Medicine · doi:10.1084/jem.72.6.747 · Cited by 350
Self-citationGutman, E. B., Sproul, E. E., & Gutman, A. B. (1936) · The American Journal of Cancer · doi:10.1158/ajc.1936.485a · Cited by 328
The Effect of Castration on Benign Hypertrophy of the Prostate in Man
Huggins, C., & Stevens, R. A. (1940) · Journal of Urology · doi:10.1016/s0022-5347(17)71453-x · Cited by 178
Self-citationTHE QUESTION OF CASTRATION FOR ENLARGED PROSTATE
CABOT, A. T. (1896) · Annals of Surgery · doi:10.1097/00000658-189607000-00036 · Cited by 148
Price, D. (1936) · American Journal of Anatomy · doi:10.1002/aja.1000600105 · Cited by 147
The Effect of Castration on Benign Hypertrophy of the Prostate in Man
Huggins, C., & Stevens, R. A. (2016) · The Journal of Urology · doi:10.1016/j.juro.2016.10.075 · Cited by 122
Self-citationTHE PRESENT POSITION OF THE SURGERY OF THE HYPERTROPHIED PROSTATE
WHITE, J. W. (1893) · Annals of Surgery · doi:10.1097/00000658-189307000-00020 · Cited by 84
Cited by
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
Watson, P. A., Arora, V. K., & Sawyers, C. L. (2015) · Nature Reviews Cancer · doi:10.1038/nrc4016 · Cited by 1,536
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
Keating, N. L., O'Malley, A. J., & Smith, M. R. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.2497 · Cited by 1,455
Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer
Taplin, M.-E., Bubley, G. J., Shuster, T. D., Frantz, M. E., Spooner, A. E., Ogata, G. K., Keer, H. N., & Balk, S. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322101 · Cited by 1,253
Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109
Androgen Deprivation Therapy for Prostate Cancer
Sharifi, N. (2005) · JAMA · doi:10.1001/jama.294.2.238 · Cited by 1,083
Metadata
- Authors
- HUGGINS, C.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1941-08-01
- Volume
- 43
- Issue
- 2
- Pages
- 209
- ISSN
- 0004-0010 (ISSN-L)
- 0272-5533
- OpenAlex
- W2035397440
- Cited by
- 1,499
- References
- 12
- FWCI
- 32.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- HUGGINS, C. (1941). STUDIES ON PROSTATIC CANCER: II. THE EFFECTS OF CASTRATION ON ADVANCED CARCINOMA OF THE PROSTATE GLAND. Archives of Surgery. https://doi.org/10.1001/archsurg.1941.01210140043004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
