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Renovascular Hypertension: Anatomic and Renal Function Changes During Drug Therapy
Abstract
Serial renal function studies were performed on 41 patients wtih renovascular hypertension (RVH) secondary to atherosclerotic renal artery disease who had been randomly selected for nonoperative management. In 19 patients, serum creatinine levels increased between 25% and 120%. The glomerular filtration rates dropped between 25% and 50% in 12 patients. Fourteen patients (37%) lost more than 10% of renal length. In four patients (12%), a significant stenosis progressed to total occlusion. Seventeen patients (41%) had deterioration of renal function or loss of renal size that led to operation. One patient required removal of a previously reconstructible kidney. Of the 17 patients with deterioration, 15 had acceptable blood pressure (BP) control during the period of nonoperative observation. Progressive deterioration of renal function in nonoperatively treated patients with atherosclerotic renal artery stenosis and RVH is common, and occurs even in the presence of BP control with drugs.
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Cited by
Safian, R. D., & Textor, S. C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440607 · Cited by 1,068
Bax, L., Woittiez, A.-J. J., Kouwenberg, H. J., Mali, W. P. T. M., Buskens, E., Beek, F. J. A., Braam, B., Huysmans, F. T. M., Schultze Kool, L. J., Rutten, M. J. C. M., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00119 · Cited by 706
Zoccali, C., Mallamaci, F., & Finocchiaro, P. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000032548.18973.0f · Cited by 428
Risk of atrophy in kidneys with atherosclerotic renal artery stenosis
Caps, M. T., Zierler, R. E., Polissar, N. L., Bergelin, R. O., Beach, K. W., Cantwell-Gab, K., Casadei, A., Davidson, R. C., & Strandness, D. E. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00805.x · Cited by 330
Natural history of atherosclerotic renal artery stenosis associated with aortic disease
Tollefson, D. F. J., & Ernst, C. B. (1991) · Journal of Vascular Surgery · doi:10.1016/0741-5214(91)90084-8 · Cited by 235
Metadata
- Authors
- Dean, R. H.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1981-11-01
- Volume
- 116
- Issue
- 11
- Pages
- 1408
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2120862215
- Cited by
- 291
- References
- 0
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dean, R. H. (1981). Renovascular Hypertension: Anatomic and Renal Function Changes During Drug Therapy. Archives of Surgery. https://doi.org/10.1001/archsurg.1981.01380230032005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
