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Cited by 439

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus: A Randomized Controlled Trial

Lee, Wei-Jei·2011·Archives of Surgery

Abstract

OBJECTIVES: To determine the efficacies of 2 weight-reducing operations on diabetic control and the role of duodenum exclusion. DESIGN: Double-blind randomized controlled trial. SETTING: Department of Surgery of the Min-Sheng General Hospital, National Taiwan University. PATIENTS: We studied 60 moderately obese patients (body mass index >25 and <35) aged >30 to <60 years who had poorly controlled type 2 diabetes mellitus (T2DM) (hemoglobin A(1c) [HbA(1c)] >7.5%) after conventional treatment (>6 months) from September 1, 2007, through June 30, 2008. Patients and observers were masked during the follow-up, which ended in 2009, 1 year after final enrollment. INTERVENTIONS: Gastric bypass with duodenum exclusion (n = 30) vs sleeve gastrectomy without duodenum exclusion (n = 30). MAIN OUTCOME MEASURES: The primary outcome was remission of T2DM (fasting glucose <126 mg/dL and HbA(1c) <6.5% without glycemic therapy). Secondary measures included weight and metabolic syndrome. Analysis was by intention to treat. RESULTS: Of the 60 patients enrolled, all completed the 12-month follow-up. Remission of T2DM was achieved by 28 (93%) in the gastric bypass group and 14 (47%) in the sleeve gastrectomy group (P = .02). Participants assigned to gastric bypass had lost more weight, achieved a lower waist circumference, and had lower glucose, HbA(1c), and blood lipid levels than the sleeve gastrectomy group. No serious complications occurred in either group. CONCLUSIONS: Participants randomized to gastric bypass were more likely to achieve remission of T2DM. Duodenum exclusion plays a role in T2DM treatment and should be assessed. Trial Registration clinicaltrials.gov Identifier: NCT00540462 (http://www.clinicaltrials.gov).

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Metadata

Authors
Lee, W.-J.
Venue
Archives of Surgery
Published
2011-02-01
Volume
146
Issue
2
Pages
143
ISSN
0004-0010 (ISSN-L)
OpenAlex
W2049070273
Cited by
439
References
12
FWCI
42.49
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus: A Randomized Controlled Trial. https://app.cochat.ai/papers/10.1001/archsurg.2010.326
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Lee, W.-J. (2011). Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Archives of Surgery. https://doi.org/10.1001/archsurg.2010.326

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