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Cited by 59Pancreatic and Hepatic Oncology ResearchGlobal Cancer Incidence and ScreeningPancreatitis Pathology and Treatment

Clinical Calculator of Conditional Survival Estimates for Resected and Unresected Survivors of Pancreatic Cancer

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Katz, Matthew H. G., Hu, Chung-Yuan, Fleming, Jason B., Pisters, Peter W. T., Lee, Jeffrey E., Chang, George J.·2012·Archives of Surgery
DOI 10.1001/archsurg.2011.2281PMC PMC3740148
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Abstract

OBJECTIVE: To calculate conditional survival estimates for patients with pancreatic adenocarcinoma. DESIGN: We constructed separate multivariate survival models adjusted for 7 clinicopathologic factors for patients who did and did not undergo radical surgical resection. PARTICIPANTS: Patients with pancreatic adenocarcinoma diagnosed between 1988 and 2005 included in the Surveillance Epidemiology End Results cancer registry. MAIN OUTCOME MEASURE: Internet browser-based calculator to compute personalized survival estimates. RESULTS: Conditional survival probabilities increased over time for all patients with pancreatic cancer regardless of patient characteristics, disease stage, or treatment. For patients with resected stage I, II, or III disease, 3-year conditional cancer-specific survival increased from 38% to 70%, 19% to 54%, and 8% to 39%, respectively, over the 3 years following diagnosis. The relative improvement in survival over time was larger for patients with advanced disease. A customizable, Internet browser-based clinical calculator was implemented that may be used to compute in real time personalized conditional survival estimates based on an individual's unique clinicopathologic profile. CONCLUSIONS: Conditional survival estimates provide a more accurate--and typically more optimistic--assessment of prognosis for patients with pancreatic cancer than traditional survival estimates that apply only at the initial diagnosis.

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  • Surgical resection remains the only reasonable hope for cure from PDAC.

    “Surgical resection remains the only reasonable hope for “cure” from PDAC.13,14”

    From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [14]

    The Discussion (page not available) says resection is associated with a subgroup of long-term survivors and that far fewer long-term survivors exist without it. It does not say resection is the only reasonable hope for cure; it also cautions that recurrence and cancer-specific death remain possible after resection. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 30

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Cited by

Sorted by citations

Authors
Katz, M. H. G., Hu, C.-Y., Fleming, J. B., Pisters, P. W. T., Lee, J. E., & Chang, G. J.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Katz, Matthew H. G.
ORCID
Venue
Archives of Surgery
Publisher
American Medical Association (AMA)
Published
2012-06-01
Volume
147
Issue
6
Pages
513-9
ISSN
0004-0010 (ISSN-L)
DOI
10.1001/archsurg.2011.2281
PMC
PMC3740148
OpenAlex
W1974337685
Cited by
59
References
2
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 2
FWCI
2.69
Type
journal article
Language
en
Open access
Locations
  • Archives of Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (K07CA133187)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords
pancreatic ductal adenocarcinoma, pancreatic cancer prognosis, radical resection, cancer-specific survival, multivariate survival models, SEER database, disease stage, clinicopathological features
MeSH terms
Adenocarcinoma, Aged, Female, Humans, Male, Middle Aged, Neoplasm Staging, Pancreatectomy, Pancreatic Neoplasms, Prognosis, Multivariate Analysis, Pancreaticoduodenectomy, SEER Program, Kaplan-Meier Estimate

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