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CARCINOMA OF THE ISLANDS OF THE PANCREAS: HYPERINSULINISM AND HYPOGLYCEMIA
Abstract
We have recently studied, both clinically and at necropsy, a case of severe spontaneous hypoglycemia. This is attributed to a tumor of the islands of Langerhans with metastasis in the liver and lymph nodes. The condition has not been described heretofore and in this sense it represents a new disease. It is well known that when the blood sugar is lowered sufficiently by the injection of insulin, a syndrome is provoked which is marked especially by tremor, tachycardia, convulsions and coma. This is ascribed to hypoglycemia, and the phenomenon has been variously designated as insulin reaction, insulin shock, hypoglycemic reaction and intoxicatio glycopriva.1Mansfeld2has produced hypoglycemia in dogs by mass ligation of the body of the pancreas which obstructs the ducts but preserves the blood supply of the distal part of the organ, and he attributes the hypoglycemia to the hypertrophy of the islands which follows the
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Cited by
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Nikfarjam, M., Warshaw, A. L., Axelrod, L., Deshpande, V., Thayer, S. P., Ferrone, C. R., & Fernández-del Castillo, C. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e31815792ed · Cited by 221
Service, F. J., & Natt, N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6934 · Cited by 168
Metadata
- Authors
- WILDER, R. M., ALLAN, F. N., POWER, M. H., & ROBERTSON, H. E.
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1927-07-30
- Volume
- 89
- Issue
- 5
- Pages
- 348
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W2057764919
- Cited by
- 443
- References
- 0
- FWCI
- 49.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CARCINOMA OF THE ISLANDS OF THE PANCREAS: HYPERINSULINISM AND HYPOGLYCEMIA. https://app.cochat.ai/papers/10.1001/jama.1927.02690050014007
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- WILDER, R. M., ALLAN, F. N., POWER, M. H., & ROBERTSON, H. E. (1927). CARCINOMA OF THE ISLANDS OF THE PANCREAS: HYPERINSULINISM AND HYPOGLYCEMIA. Journal of the American Medical Association. https://doi.org/10.1001/jama.1927.02690050014007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
