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SODIUM DIPHENYL HYDANTOINATE IN THE TREATMENT OF CONVULSIVE DISORDERS
Abstract
Good results in the treatment of patients with convulsive seizures have been obtained by a variety of methods, such as medical treatment with bromides or barbituric acid compounds, the ketogenic diet, restriction of fluids, and the surgical excision of scars or irritable cortical foci. In spite of these various therapeutic means there are a great number of patients who are not relieved of their attacks or are helped only temporarily by treatment. The fact that treatment by anticonvulsant drugs is at present the most widely used and on the whole the most effective method of therapy suggested to us the possibility that a direct and systematic experimental search might reveal more potent and less sedative compounds. With this idea in mind we devised an experimental proecdure1which would produce convulsive seizures in animals at a constant threshold and which would allow for a qualitative and roughly quantitative determination of
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Cited by
Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.
Shear, N. H., & Spielberg, S. P. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113798 · Cited by 687
Löscher, W. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2222-z · Cited by 367
Ketogenic diet and other dietary treatments for epilepsy
Levy, R. G., Cooper, P. N., Giri, P., & Weston, J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001903.pub2 · Cited by 312
Hallmon, W. W., & Rossmann, J. A. (1999) · Periodontology 2000 · doi:10.1111/j.1600-0757.1999.tb00175.x · Cited by 148
Hyperplasia of the Gingivae Associated with Dilantin (Sodium Diphenyl Hydantoinate) Therapy
Glickman, I., & Lewitus, M. P. (1941) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1941.0040 · Cited by 57
Metadata
- Authors
- MERRITT, H. H.
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1938-09-17
- Volume
- 111
- Issue
- 12
- Pages
- 1068
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W4240407292
- Cited by
- 457
- References
- 0
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: SODIUM DIPHENYL HYDANTOINATE IN THE TREATMENT OF CONVULSIVE DISORDERS. https://app.cochat.ai/papers/10.1001/jama.1938.02790380010004
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- MERRITT, H. H. (1938). SODIUM DIPHENYL HYDANTOINATE IN THE TREATMENT OF CONVULSIVE DISORDERS. Journal of the American Medical Association. https://doi.org/10.1001/jama.1938.02790380010004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
