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TOXOPLASMIC ENCEPHALITIS IN CHILDREN
Abstract
It has been abundantly demonstrated in recent years that acute nonsuppurative encephalitis is a syndrome of multiple etiology. My purpose in the present communication is (1) to present evidence that organisms of the genus Toxoplasma can be the cause of such encephalitis in children, (2) to describe the clinical and pathologic appearances and (3) to indicate the steps which can be taken to establish the diagnosis. PRESENT STATUS OF TOXOPLASMA Toxoplasma is a genus of protozoan parasites which were first observed in the gondi (North African rodent) in 1908 by Nicolle and Manceaux,1who differentiated it from Leishmania, and independently in the same year in the rabbit (Brazil) by Splendore.2They are highly organized parasites consisting of distinct cytoplasm and nuclear chromatin and are crescentic, pyriform, oval or round, measuring 6 to 7 microns in length and 2 to 4 microns in width, depending on the stage of
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Cited by
Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines
Mordue, D. G., Monroy, F., La Regina, M., Dinarello, C. A., & Sibley, L. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4574 · Cited by 396
Efficient Gene Replacements in Toxoplasma gondii Strains Deficient for Nonhomologous End Joining
Fox, B. A., Ristuccia, J. G., Gigley, J. P., & Bzik, D. J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00357-08 · Cited by 263
Vaccines against Toxoplasma gondii: challenges and opportunities
Jongert, E., Roberts, C. W., Gargano, N., Förster-Waldl, E., & Petersen, E. (2009) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762009000200019 · Cited by 205
Lilue, J., Müller, U. B., Steinfeldt, T., & Howard, J. C. (2013) · eLife · doi:10.7554/elife.01298 · Cited by 109
Metadata
- Authors
- SABIN, A. B.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1941-03-01
- Volume
- 116
- Issue
- 9
- Pages
- 801
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2069487431
- Cited by
- 523
- References
- 0
- FWCI
- 31.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- SABIN, A. B. (1941). TOXOPLASMIC ENCEPHALITIS IN CHILDREN. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1941.02820090001001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
