CHRONIC THYROIDITIS AND AUTOIMMUNIZATION
Abstract
• An explanation of chronic thyroiditis in man was sought in observations made on rabbits, dogs, guinea pigs, and human subjects. The rabbits received injections of saline extracts of rabbit thyroid glands. The tests for circulating autoantibodies utilized the phenomena of precipitation, complement fixation, and tanned-cell hemagglutination. The third of these, based upon the principle of altering the surface of the red blood cells by dilute tannic acid so that they absorb proteins, was particularly sensitive. The three tests were applied to serums from 35 rabbits injected with rabbit thyroid extract, and thyroid autoantibodies were found in 32. Structural damage was found in the thyroid roughly in proportion to the autoantibody titer in the serum. Similar studies were carried out in dogs and guinea pigs with canine and guinea pig thyroid extracts respectively. The three tests were then applied to serums from patients with chronic thyroiditis. Twelve such patients were found whose serums contained circulating antibodies specifically directed against extracts of human thyroid glands. Three typical case histories are given, with histological findings on thyroid tissue removed during surgery. Six other patients with chronic thyroiditis, proved histologically, were not found to have autoantibodies in their serums at the time of study. These findings lead to the hypotheses that some types of chronic thyroiditis are related to an autoimmunization process within the patient against…
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Following discovery of an autoimmune basis for other endocrine diseases, researchers began to consider autoimmunity as an etiology of insulin-deficient diabetes.
“Not until the 1950s, following the discovery of an autoimmune basis for other endocrine diseases, did researchers begin to consider autoimmunity as an etiology of insulin-deficient diabetes29–31.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [31]
Cites
AUTO-ANTIBODIES IN HASHIMOTO'S DISEASE (LYMPHADENOID GOITRE)
Roitt, I. M., Doniach, D., Campbell, P. N., & Vaughan Hudson, R. (1956) · The Lancet · doi:10.1016/s0140-6736(56)92249-8 · Cited by 575 · see citing works
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Gender differences in autoimmune disease
Ngo, S. T., Steyn, F. J., & McCombe, P. A. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.004 · Cited by 1,074 · see citing works
Betterle, C., Dal Pra, C., Mantero, F., & Zanchetta, R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0466 · Cited by 758 · see citing works
100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
An expert opinion on PANDAS/PANS: highlights and controversies
Chiarello, F., Spitoni, S., Hollander, E., Matucci Cerinic, M., & Pallanti, S. (2017) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2017.1285941 · Cited by 50 · see citing works
- Authors
- Witebsky, E.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Witebsky, Ernest
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1957-07-27
- Volume
- 164
- Issue
- 13
- Pages
- 1439
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W2041094538
- Cited by
- 547
- References
- 1
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 18 · 2013: 18 · 2012: 8
- FWCI
- 37.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- chronic thyroiditis, thyroid autoantibodies, autoimmunization, complement fixation, precipitation test, thyroid histology
- MeSH terms
- Chronic Disease, Humans, Thyroiditis, Hashimoto Disease
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