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Thrombophlebitis and Cancer
Abstract
Records of 1,400 patients with the diagnosis of venous thrombosis or thrombophlebitis were reviewed. Eighty-one had associated cancer. In 61, the thrombophlebitis was diagnosed clinically; in 20, at autopsy. Fifty-one had carcinoma. Thrombophlebitis was recognized in 31 prior to the carcinoma. Other types of malignancy also showed this relationship. The lungs, female reproductive tract, and the pancreas were most frequent sites for the primary lesion. The resistance to anticoagulant therapy used in the treatment of thrombophlebitis was striking. Phlebitis sometimes persists or recurs over long periods of time before the cancer is discovered. These characteristics should be regarded as warning signs indicating a comprehensive survey for occult cancer.
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Citations
Cited by
Venous Thromboembolism and Cancer: Risks and Outcomes
Lee, A. Y. Y., & Levine, M. N. (2003) · Circulation · doi:10.1161/01.cir.0000078466.72504.ac · Cited by 721
Bodai, B. I., & Tuso, P. (2015) · The Permanente Journal · doi:10.7812/tpp/14-241 · Cited by 397
Thrombocytosis Associated With Malignant Disease
LEVIN, J. (1964) · Archives of Internal Medicine · doi:10.1001/archinte.1964.03860100079008 · Cited by 295
Young, A., Chapman, O., Connor, C., Poole, C., Rose, P., & Kakkar, A. K. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.106 · Cited by 150
Metadata
- Authors
- Lieberman, J. S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1961-08-26
- Volume
- 177
- Issue
- 8
- Pages
- 542
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2074535034
- Cited by
- 184
- References
- 0
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- closed
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