The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Induction of Ovulation with MRL/41: Preliminary Report
Abstract
MRL/41, an analogue of the nonsteroid estrogen, chlorotrianisene, was evaluated in the human female because it was shown to possess pituitary gonadotropin-inhibiting and antifecundity properties in rats. Although structurally related to a hormone-like chemical agent, this compound does not exhibit estrogenic, progestogenic, or androgenic activity in the human. Studies with this drug were initiated primarily because of its potential as an antifertility agent. Contrary to expectations, some unsuspected and interesting biological activities were observed, one of which was the induction of ovulatorytype menses in amenorrheic anovulatory females.
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“Clomiphene citrate has been widely used in the treatment of infertility since its introduction into clinical practice in the 1960s (1).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [1]
Citations
Cites
Amenorrhea associated with bilateral polycystic ovaries
Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121
CLINICAL EFFECT OF HUMAN PITUITARY FOLLICLE-STIMULATING HORMONE (FSH)*
GEMZELL, C. A., Diczfalusy, E., & TILLINGER, G. (1958) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-18-12-1333 · Cited by 333
Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.
Holtkamp, D. E., GRESLIN, J. G., Root, C. A., & Lerner, L. J. (1960) · Experimental Biology and Medicine · doi:10.3181/00379727-105-26054 · Cited by 138
Rakoff, A. E. (1953) · Fertility and Sterility · doi:10.1016/s0015-0282(16)31323-1 · Cited by 18
Cited by
Sorted by citations
The pharmacology and clinical uses of tamoxifen
Furr, B. J. A., & Jordan, V. C. (1984) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(84)90043-3 · Cited by 864
Tamoxifen: a most unlikely pioneering medicine
Jordan, V. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1031 · Cited by 832
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Macklon, N., Stouffer, R. L., Giudice, L. C., & Fauser, B. C. J. M. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0015 · Cited by 572
Ovarian Hyperstimulation Syndrome: A Current Survey
Wallach, E. E., Schenker, J. G., & Weinstein, D. C. (1978) · Fertility and Sterility · doi:10.1016/s0015-0282(16)43508-9 · Cited by 511
Jordan, V. C. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020449y · Cited by 414
Metadata
- Authors
- Greenblatt, R. B.
- Corresponding author
- Greenblatt, Robert B.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1961-10-14
- Volume
- 178
- Issue
- 2
- Pages
- 101
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2068435339
- Cited by
- 343
- References
- 4
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 21.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- ovulation induction, amenorrhea, anovulation, antifertility agents, gonadotropin suppression, menstrual induction
- MeSH terms
- Female, Humans, Ovulation, Stilbenes
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