The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Influence of Cholestyramine on Thyroxine Absorption
Abstract
Cholestyramine resin, an anionic exchange resin, currently being investigated as an agent for lowering serum cholesterol levels, has been shown to interfere with the absorption of ingested thyroid hormone. A small quantity of the resin is capable of binding thyroxine under the conditions encountered in the gastrointestinal tract. Interference with thyroid hormone absorption by cholestyramine can be minimized by allowing a time interval of at least four hours between the ingestion of the two agents. Hypothyroid patients receiving cholestyramine should be examined periodically for evidence of hypothyroidism, and adjustments in dose and time interval between the two agents should be made if malabsorption of thyroid hormone is significant.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The list of medications that can alter the absorption of LT4 is extensive and includes calcium carbonate (132-134), PPIs (135), bile acid sequestrants (cholestyramine and colesevelam) (136,137), phosphate binders (138,139), ferrous sulfate (140,141), aluminum-containing antacids (142,143), and sucralfate (144,145).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [136]
In the citing paper
“Both of these reports incorporated pharmacokinetic studies in healthy volunteers showing reduced absorption with co-administration of the agent and LT4.”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [136]
In the citing paper
“Two studies have implicated bile acid sequestrants as being responsible for binding LT4 within the intestine (136,137).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [136]
In the citing paper
“It is widely acknowledged that direct complexation and chelation play important roles in the malabsorption of LT4 induced by the intake of many drugs, including calcium and iron supplements (72, 73), aluminum-containing antacids (74), bile acid sequestrants (75, 76), and some foods (eg, fiber-rich foods, coffee, and milk) (22, 77, 78).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [75]
Citations
Cites
Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders
Fredrickson, D. S., Levy, R. I., & Lees, R. S. (1967) · New England Journal of Medicine · doi:10.1056/nejm196701052760107 · Cited by 1,911
In Vitro Method for the Study of the Rate of Intestinal Absorption of Sugars
Crane, R. K., & Wilson, T. H. (1958) · Journal of Applied Physiology · doi:10.1152/jappl.1958.12.1.145 · Cited by 173
Effect of an Anion Exchange Resin on Serum Cholesterol in Man.
Bergen, S. S., Itallie, T. B. V., Tennent, D. M., & Sebrell, W. H. (1959) · Experimental Biology and Medicine · doi:10.3181/00379727-102-25358 · Cited by 101
The Interaction Between Cholestyramine and Drugs
Gallo, D. G., Bailey, K. R., & Sheffner, A. L. (1965) · Experimental Biology and Medicine · doi:10.3181/00379727-120-30443 · Cited by 88
Moore, R. B., Crane, C. A., & Frantz, I. D. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105857 · Cited by 76
Response of Hyperlipoproteinemia to Cholestyramine Resin
Fallon, H. J. (1968) · JAMA · doi:10.1001/jama.1968.03140260001001 · Cited by 51
INFLUENCE OF CHOLESTYRAMINE ON ABSORPTION AND EXCRETION OF THYROXINE IN SYRIAN HAMSTER
Bergman, F., Heedman, P., & LINDEN, W. V. D. (1966) · European Journal of Endocrinology · doi:10.1530/acta.0.0530256 · Cited by 25
Enterohepatic circulation of thyroxine in humans.
Myant, N. B. (1956) · PubMed · Cited by 25
Johnson, P. C., & Beierwaltes, W. H. (1953) · PubMed · Cited by 11
Cited by
Sorted by citations
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“Two studies have implicated bile acid sequestrants as being responsible for binding LT4 within the intestine (136,137).”
Satoh, T., Isozaki, O., Suzuki, A., Wakino, S., Iburi, T., Tsuboi, K., Kanamoto, N., Otani, H., Furukawa, Y., Teramukai, S., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0336 · Cited by 262
Conditions and drugs interfering with thyroxine absorption
Liwanpo, L., & Hershman, J. M. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.06.006 · Cited by 222
Effect of calcium carbonate on the absorption of levothyroxine
Singh, N. (2000) · JAMA · doi:10.1001/jama.283.21.2822 · Cited by 219
Dietary and Drug Treatment of Primary Hyperlipoproteinemia
Levy, R. I., FREDRICKSON, D. S., SHULMAN, R., BILHEIMER, D. W., Breslow, J. L., STONE, N. J., LUX, S. E., SLOAN, H. R., Krauss, R. M., & HERBERT, P. N. (1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-77-2-267 · Cited by 183
Metadata
- Authors
- Northcutt, R. C.
- Corresponding author
- Northcutt, Robert C.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1969-06-09
- Volume
- 208
- Issue
- 10
- Pages
- 1857
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1998922937
- Cited by
- 144
- References
- 9
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- cholestyramine, anion exchange resin, hypothyroidism, drug interactions, serum cholesterol lowering, timing of drug administration
- MeSH terms
- Animals, Anticholesteremic Agents, Cholestyramine Resin, Female, Humans, Intestinal Absorption, Iodine, Iodine Isotopes, Ion Exchange Resins, Thyroid Hormones, Thyroxine, Time Factors, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
