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Clofibrate and Niacin in Coronary Heart Disease
Abstract
THE RELATIONSHIP of serum cholesterol level to prevalence, incidence, and mortality from coronary heart disease (CHD) has been demonstrated in many epidemiological studies.1-6It is also known that serum cholesterol levels frequently can be influenced over long periods of time by available drugs. However, three key questions about such pharmaceutical agents need to be answered: Can they prevent the development of CHD? Can they prevent new CHD events or prolong life in persons already displaying clinical CHD? Are they reasonably free of adverse effects in long-term usage? The Coronary Drug Project—a nationwide collaborative study sponsored by the National Heart and Lung Institute—represents an extensive effort undertaken to answer the latter two of these questions with regard to men who have already experienced one or more verified episodes of myocardial infarction (MI).7-13 As previously reported, three of the Coronary Drug Project treatment regimens were discontinued before the scheduled completion
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Cited by
Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902
Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882
Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170
Metadata
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1975-01-27
- Volume
- 231
- Issue
- 4
- Pages
- 360
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2725187802
- Cited by
- 1,747
- References
- 0
- FWCI
- 98.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Clofibrate and Niacin in Coronary Heart Disease. (1975). JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1975.03240160024021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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