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Caffeine as an Analgesic Adjuvant
Abstract
Thirty clinical studies involving more than 10,000 patients conducted during the last 20 years have been analyzed to assess the value of caffeine as an analgesic adjuvant. Although most studies included patients with postpartum uterine cramping or episiotomy pain, some involved patients with pain from oral surgery or headache. In 21 of 26 studies, the relative potency estimates of an analgesic with caffeine to an analgesic without caffeine is greater than one. The pooled relative potency estimates in each of several major categories of combination analgesics are significantly greater than one. The overall pooled relative potency estimate is 1.41, with 95% confidence limits of 1.23 to 1.63; that is, to obtain the same amount of response from an analgesic without caffeine requires a dose that is approximately 40% greater than one with caffeine.
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Cited by
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557
Diener, H., Pfaffenrath, V, Pageler, L., Peil, H., & Aicher, B. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00948.x · Cited by 223
Lipton, R. B., Stewart, W. F., Ryan, R. E., Saper, J., Silberstein, S., & Sheftell, F. (1998) · Archives of Neurology · doi:10.1001/archneur.55.2.210 · Cited by 223
Hudson, G. M., Green, J. M., Bishop, P. A., & Richardson, M. T. (2008) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31818219cb · Cited by 94
Metadata
- Authors
- Laska, E. M.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1984-04-06
- Volume
- 251
- Issue
- 13
- Pages
- 1711
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2051619456
- Cited by
- 268
- References
- 0
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
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