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Clinical Epidemiology: The Architecture of Clinical Research
Abstract
Some years ago, I read, with growing enthusiasm,Clinical Judgment, Alvan Feinstein's defense of the scientific validity of clinical medicine and clinical opinions. Written in an era during which the grants for basic and clinical research threatened to make second-class citizens of those physicians who saw patients, this tour de force legitimized clinical practice. Now, the same author is back, with a massive tome that applies Occam's razor to clinical experimentation. His new book defines the terms, sets the limitations, hones the critical judgment, and firmly bases the fundamentals for those who would conduct clinical research, judge it, or read about it. This massive book painstakingly examines and defines all the concepts that underlie clinical decisions. It presents the statistical background for judgments. It permits the reader to analyze studies in journals and is thus essential for those who would design their own prospective or retrospective studies. It points out
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Cited by
Lewis, G., Pelosi, A. J., Araya, R., & Dunn, G. (1992) · Psychological Medicine · doi:10.1017/s0033291700030415 · Cited by 1,487
Recall bias in epidemiologic studies
Coughlin, S. S. (1990) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(90)90060-3 · Cited by 1,381
Genetic associations in large versus small studies: an empirical assessment
Ioannidis, J. P., Trikalinos, T. A., Ntzani, E. E., & Contopoulos-Ioannidis, D. G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12516-0 · Cited by 579
The prevalence and impact of alcohol problems in major depression: A systematic review
Sullivan, L. E., Fiellin, D. A., & O’Connor, P. G. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.01.007 · Cited by 489
Economou, M., Trikalinos, T. A., Loizou, K. T., Tsianos, E. V., & Ioannidis, J. P. A. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40304.x · Cited by 465
Metadata
- Authors
- Ehrlich, G. E.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1985-10-11
- Volume
- 254
- Issue
- 14
- Pages
- 1997
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2014930062
- Cited by
- 420
- References
- 0
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical Epidemiology: The Architecture of Clinical Research. https://app.cochat.ai/papers/10.1001/jama.1985.03360140159045
- The paper
- Ehrlich, G. E. (1985). Clinical Epidemiology: The Architecture of Clinical Research. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1985.03360140159045
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
