Obesity as a Predictor of Poor Antibody Response to Hepatitis B Plasma Vaccine
Abstract
Factors associated with lack of antibody response to the hepatitis B virus plasma vaccine were retrospectively evaluated by means of a logistic regression in 194 previously seronegative staff members of a community hospital. All subjects had received three doses of vaccine by intramuscular buttock injection using a 1-in, 23-gauge needle. Overall, only 55.7% of subjects developed detectable antibody to hepatitis B surface antigen in serum after immunization. The weight-height index served as a surrogate measure of obesity. Predictors of poor immunogenic response to hepatitis B vaccine included higher weight-height index, older age, and vaccine batch. Sex, race, timing of vaccine doses, and timing of postimmunization determination of antibody to hepatitis B surface antigen were not predictors of vaccine efficacy.
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Obesity is associated with systemic inflammation and impaired immunity.
“Obesity is associated with systemic inflammation and impaired immunity.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [29]
In a study of treatment response in obese subjects, obesity may be a predictor of poor antibody response.
“In a study of treatment response in obese subjects, Weber et al. [29] first reported that obesity may be a predictor of poor antibody response.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [29]
Altered immunity in obesity is associated with reduced responses to Hepatitis B and tetanus vaccines and increased susceptibility to influenza.
“This altered immunity has been associated with suboptimal (reduced) responses to vaccines, including Hepatitis B26 and tetanus,27 and increased susceptibility to influenza.28”
From SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges (2021) · cites this paper as [26]
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References 16 · Cited by 345
- Authors
- Weber, D. J.
- Corresponding author
- Weber, David J.
- ORCID
- Weber, David J.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1985-12-13
- Volume
- 254
- Issue
- 22
- Pages
- 3187
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2019878496
- Cited by
- 345
- References
- 16
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 25 · 2021: 22 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 18 · 2016: 8 · 2015: 24 · 2014: 13 · 2013: 13 · 2012: 16
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- obesity, hepatitis B vaccine, antibody response, vaccine immunogenicity, hepatitis B surface antigen, age
- MeSH terms
- Adult, Age Factors, Analysis of Variance, Buttocks, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hospital Bed Capacity, 100 to 299, Humans, Injections, Intramuscular, Male, North Carolina, Obesity, Occupational Diseases, Personnel, Hospital, Retrospective Studies, Viral Hepatitis Vaccines, Hepatitis B Vaccines
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