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Fundamentals of Clinical Trials
Abstract
The randomized clinical trial has become a significant career focus for an eclectic group of professionals, which includes physicians, epidemiologists, statisticians, computer specialists, compliance experts, nurse coordinators, and others. A society for clinical trials has evolved, which now has about 1500 members and publishes a quarterly journal. Courses in clinical trials are widely available, and several books have appeared to summarize the considerable practical experience and burgeoning methodological literature. Friedman and his collaborators brought out one of the first of these in 1981, which they have now updated. It is a well-written little book, which can be read in a day or so but could equally well serve as the basis for a semester course. The basic concepts underlying clinical trials are easily grasped, so most of the subject matter is accessible to the statistically unsophisticated reader. The authors have organized the book around a series of "fundamental points," which
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Cited by
Sample size slippages in randomised trials: exclusions and the lost and wayward.
Schulz, K. F., & Grimes, D. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07882-0 · Cited by 642
The double-blind, randomized, placebo-controlled trial
Kaptchuk, T. J. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00347-4 · Cited by 595
Binder, E. F., Schechtman, K. B., Ehsani, A. A., Steger‐May, K., Brown, M., Sinacore, D. R., Yarasheski, K. E., & Holloszy, J. O. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50601.x · Cited by 549
Hvas, C. L., Dahl Jørgensen, S. M., Jørgensen, S. P., Storgaard, M., Lemming, L., Hansen, M. M., Erikstrup, C., & Dahlerup, J. F. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.019 · Cited by 390
Saari-Kemppainen, A., Karjalainen, O., Ylostalo, P., & Heinonen, O. P. (1990) · The Lancet · doi:10.1016/0140-6736(90)91941-3 · Cited by 359
Metadata
- Authors
- Rhoads, G. G.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1986-08-22
- Volume
- 256
- Issue
- 8
- Pages
- 1055
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2008964214
- Cited by
- 342
- References
- 0
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fundamentals of Clinical Trials. https://app.cochat.ai/papers/10.1001/jama.1986.03380080101043
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- Rhoads, G. G. (1986). Fundamentals of Clinical Trials. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1986.03380080101043
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
