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Cited by 529

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Glycosylated Hemoglobin Predicts the Incidence and Progression of Diabetic Retinopathy

Klein, Ronald·1988·JAMA: The Journal of the American Medical Association

Abstract

The relationship between hyperglycemia, measured by glycosylated hemoglobin at the initial examination, and the four-year incidence and progression of diabetic retinopathy was examined in a population-based study in Wisconsin. Younger- (n = 891) and older-onset (n = 987) persons participating in baseline and follow-up examinations were included. Glycosylated hemoglobin was measured by microcolumn. Retinopathy was determined from stereoscopic fundus photographs. In the younger-onset group, comparing the highest with the lowest quartile of glycosylated hemoglobin, the relative risk for developing any diabetic retinopathy was 1.9; for proliferative retinopathy, 21.8; and for progression, 4.0. Among older-onset persons taking insulin, the corresponding relative risks were 1.9, 4.0, and 2.1. Among older-onset persons not taking insulin, relative risks were 4.0 for any retinopathy and 6.2 for progression. A positive relationship between incidence and progression of retinopathy and glycosylated hemoglobin remained after controlling for duration of diabetes, age, sex, and baseline retinopathy. These data suggest a strong and consistent relationship between hyperglycemia and incidence and progression of retinopathy.

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Metadata

Authors
Klein, R.
Venue
JAMA: The Journal of the American Medical Association
Published
1988-11-18
Volume
260
Issue
19
Pages
2864
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W2034900477
Cited by
529
References
3
FWCI
16.93
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Glycosylated Hemoglobin Predicts the Incidence and Progression of Diabetic Retinopathy. https://app.cochat.ai/papers/10.1001/jama.1988.03410190112033
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Klein, R. (1988). Glycosylated Hemoglobin Predicts the Incidence and Progression of Diabetic Retinopathy. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1988.03410190112033

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