The DOI matches its Crossref record.
Prevalence of Alzheimer's Disease in a Community Population of Older Persons: Higher Than Previously Reported
Abstract
Clinically diagnosed Alzheimer's disease and other dementing illnesses were assessed in a geographically defined US community. Of 3623 persons (80.8% of all community residents over 65 years of age) who had brief memory testing in their homes, a stratified sample of 467 persons underwent neurological, neuropsychological, and laboratory examination. Prevalence rates of Alzheimer's disease were calculated for the community population from the sample undergoing clinical evaluation. Of those over the age of 65 years, an estimated 10.3% (95% confidence limits, 8.1% and 12.5%) had probable Alzheimer's disease. This prevalence rate was strongly associated with age. Of those 65 to 74 years old, 3.0% (95% confidence limits, 0.8 and 5.2) had probable Alzheimer's disease, compared with 18.7% (95% confidence limits, 13.2 and 24.2) of those 75 to 84 years old and 47.2% (95% confidence limits, 37.0 and 63.2) of those over 85 years. Other dementing conditions were uncommon. Of community residents with moderate or severe cognitive impairment, 84.1% had clinically diagnosed Alzheimer's disease as the only probable diagnosis. These data suggest that clinically diagnosed Alzheimer's disease is a common condition and that its public health impact will continue to increase with increasing longevity of the population. (JAMA. 1989;262:2551-2556)
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“Based on studies that show clinical AD [6, 8], MCI [88], and preclinical AD [67] are common in the elderly, by this scheme that vast majority of those past the age of 85 have AD (Figure 2).”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [6]
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Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey–Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001) · Neurology · doi:10.1212/wnl.56.9.1143 · Cited by 1,410
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207
Clinical Neurology and Epidemiology of the Major Neurodegenerative DiseasesPreprint
Erkkinen, M. G., Kim, M., & Geschwind, M. D. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033118 · Cited by 1,231
“Atypical cases of AD (see description above) can closely resemble FTD spectrum disorders (primary progressive aphasia [PPA], bvFTD), and in these cases MRI and AD biomarker studies (e.g., amyloid-PET, CSF Ab1-42 amyloid, t-tau, and p-tau) can help distinguish the two diagnostic entities.”
BackgroundInfluentialZhang, M., Katzman, R., Salmon, D. P., Jin, H., Cai, G., Wang, Z., Qu, G.-Y., Grant, I., Yu, E. S. H., Levy, P. S., et al. (1990) · Annals of Neurology · doi:10.1002/ana.410270412 · Cited by 1,068
Metadata
- Authors
- Evans, D. A.
- Corresponding author
- Evans, Denis A.
- ORCID
- Evans, Denis A.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1989-11-10
- Volume
- 262
- Issue
- 18
- Pages
- 2551
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2129678592
- Cited by
- 1,226
- References
- 0
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 15 · 2022: 9 · 2021: 20 · 2020: 22 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 28 · 2015: 23 · 2014: 17 · 2013: 32 · 2012: 25
- FWCI
- 44.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Funders
- National Institute on Aging (N01-AG02107, N01‐AG‐1‐2106, AG 06789)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- Alzheimer's disease, prevalence, older adults, dementia, age-related cognitive decline, community-dwelling older adults, cognitive impairment, age differences in prevalence, public health impact
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