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Cited by 349

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Risk of Neural Tube Defect—Affected Pregnancies Among Obese Women

Shaw, Gary M.·1996·JAMA: The Journal of the American Medical Association
DOI 10.1001/jama.1996.03530380035028
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Abstract

OBJECTIVE: To investigate the risk for neural tube defect (NTD)-affected pregnancies among obese women (ie, women with a body mass index [BMI] > 29kg/m2) compared with women of average prepregnancy weight. DESIGN: Population-based case-control study. SETTING: All hospitals in 55 of 58 counties in California. PARTICIPANTS: In-person interviews were conducted with mothers of 538 (88% of eligible) NTD cases (including fetuses and infants electively terminated, stillborn, or born alive) and with mothers of 539 nonmalformed controls (88%) within an average of 5 months from the term delivery date. MAIN OUTCOME MEASURES: The risk of an NTD-affected pregnancy among obese women. RESULTS: Compared with women whose BMI was less than or equal to 29 kg/m2, an increased risk for NTD-affected pregnancy was observed among obese women (odds ratio, 1.9; 95% confidence interval, 1.3 to 2.9). The increased risk was not attributable to maternal nonuse of a vitamin containing folic acid, diabetes, use of diet pills, lower dietary folate intake, or an NTD-pregnancy history. Adjustment for maternal age, education, gravidity, use of vitamins, and use of alcohol did not change the odds ratio. The risk associated with maternal obesity was greater for spina bifida and for other less prevalent NTDs than for anencephaly. CONCLUSION: Because as many as 10% of women may be obese periconceptionally, the observed twofold increased risk is relevant to the population burden of NTDs.

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Metadata

Authors
Shaw, G. M.
Venue
JAMA: The Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1996-04-10
Volume
275
Issue
14
Pages
1093
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1996.03530380035028
OpenAlex
W2005190933
Cited by
349
References
12
FWCI
10.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Risk of Neural Tube Defect—Affected Pregnancies Among Obese Women. https://app.cochat.ai/papers/10.1001/jama.1996.03530380035028
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Shaw, G. M. (1996). Risk of Neural Tube Defect—Affected Pregnancies Among Obese Women. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1996.03530380035028

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.