Composite End Points in Randomized Trials: There Is No Free Lunch
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The use of a combined endpoint will give problems if the predictor effect is in opposite directions for different outcomes included in the composite endpoint.
“The use of a combined endpoint will give problems if the predictor effect is in opposite directions for different outcomes included in the composite endpoint [52],[53].”
From Reporting and Methods in Clinical Prediction Research: A Systematic Review (2012) · cites this paper as [52]
The citation lists haven’t been fetched yet
References 10 · Cited by 121
- Authors
- Tomlinson, G., & Detsky, A. S.
- Affiliations
- University of Toronto (CA)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2010-01-20
- Volume
- 303
- Issue
- 3
- Pages
- 267
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2018323223
- Cited by
- 121
- References
- 10
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 11
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Keywords
- composite endpoints, clinical trial endpoints, endpoint definition
- MeSH terms
- Rosiglitazone, Decision Making, Diabetes Mellitus, Humans, Hypoglycemic Agents, Randomized Controlled Trials as Topic, Treatment Outcome, Endpoint Determination, Thiazolidinediones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
