The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk
Open accessAbstract
CONTEXT: Multiple studies have linked alcohol consumption to breast cancer risk, but the risk of lower levels of consumption has not been well quantified. In addition, the role of drinking patterns (ie, frequency of drinking and "binge" drinking) and consumption at different times of adult life are not well understood. OBJECTIVE: To evaluate the association of breast cancer with alcohol consumption during adult life, including quantity, frequency, and age at consumption. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational study of 105,986 women enrolled in the Nurses' Health Study followed up from 1980 until 2008 with an early adult alcohol assessment and 8 updated alcohol assessments. MAIN OUTCOME MEASURES: Relative risks of developing invasive breast cancer. RESULTS: During 2.4 million person-years of follow-up, 7690 cases of invasive breast cancer were diagnosed. Increasing alcohol consumption was associated with increased breast cancer risk that was statistically significant at levels as low as 5.0 to 9.9 g per day, equivalent to 3 to 6 drinks per week (relative risk, 1.15; 95% CI, 1.06-1.24; 333 cases/100,000 person-years). Binge drinking, but not frequency of drinking, was associated with breast cancer risk after controlling for cumulative alcohol intake. Alcohol intake both earlier and later in adult life was independently associated with risk. CONCLUSIONS: Low levels of alcohol consumption were associated with a small increase in breast cancer risk, with the most consistent measure being cumulative alcohol intake throughout adult life. Alcohol intake both earlier and later in adult life was independently associated with risk.
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“The main biological pathway seems to be through overall tissue exposure to acetaldehyde, which may not be affected by drinking patterns; however, through modifications of insulin‐like growth factor (IGF) serum levels, drinking patterns may have an effect on the risk of developing breast cancer (as well as other cancers, where modifications to IGF serum levels play a role 180).”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [180]
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“through modifications of insulin‐like growth factor (IGF) serum levels, drinking patterns may have an effect on the risk of developing breast cancer (as well as other cancers, where modifications to IGF serum levels play a role 180).”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [180]
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Citations
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Self-citationEffects of Alcohol Consumption on Plasma and Urinary Hormone Concentrations in Premenopausal Women
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“A metaanalysis found that studies with shorter duration of follow-up reported higher RRs than studies with longer followup, suggesting that recent, rather than early, alcohol intake is more strongly associated with breast cancer risk.(38) Alternatively, for studies that do not obtain updated assessments through a pers…”
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“Consistent with other studies, we did not find any difference by type of alcoholic beverage (ie, beer, wine, or liquor).(2,3,18,19) Although the exact mechanism for the association between alcohol consumption and breast cancer is not known, one probable explanation would involve alcohol’s effects on circulating estrog…”
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BackgroundAlcohol and Endogenous Sex Steroid Levels in Postmenopausal Women: A Cross-Sectional Study
Onland‐Moret, N. C., Peeters, P. H. M., van der Schouw, Y. T., Grobbee, D. E., & van Gils, C. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0614 · Cited by 120 · cited 1×
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“In terms of binge drinking, a prospective study showed a nonlinear association with the highest risk among women who consumed 4 to 5 drinks per weekday or 16 to 21 drinks per weekend and lower risks for women who drank more, but they had few cases in the highest categories and contrary to most studies, nondrinkers had…”
ResultLi, C. I., Malone, K. E., Porter, P. L., Weiss, N. S., Tang, M.-T. C., & Daling, J. R. (2003) · PubMed · Cited by 63
Alcohol consumption and risk of breast cancer: a cohort study
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Alcohol Consumption and Breast Cancer among Black and White Women in North Carolina (United States)
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“Consistent with other studies, we did not find any difference by type of alcoholic beverage (ie, beer, wine, or liquor).(2,3,18,19) Although the exact mechanism for the association between alcohol consumption and breast cancer is not known, one probable explanation would involve alcohol’s effects on circulating estrog…”
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American Cancer Society guidelines on nutrition and physical activity for cancer prevention
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BackgroundThe relationship between different dimensions of alcohol use and the burden of disease—an update
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“Consumption of alcohol, even at low levels, is causally associated with increased risk for female breast cancer (Brooks and Zakhari, 2013; Gunter et al., 2012; Hansen et al., 2009; Nishiyama et al., 2011; Page et al., 2013; Rosner et al., 2011; Scoccianti et al., 2014; Seitz et al., 2012; Singletary and Gapstur, 2001;…”
Background
Metadata
- Authors
- Chen, W. Y., Rosner, B., Hankinson, S. E., Colditz, G. A., & Willett, W. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Chen, Wendy Y.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2011-11-02
- Volume
- 306
- Issue
- 17
- Pages
- 1884
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC3292347
- OpenAlex
- W2062112003
- Cited by
- 509
- References
- 43
- Citations by year
- 2026: 23 · 2025: 20 · 2024: 29 · 2023: 32 · 2022: 28 · 2021: 43 · 2020: 34 · 2019: 45 · 2018: 21 · 2017: 30 · 2016: 46 · 2015: 46 · 2014: 32 · 2013: 32 · 2012: 41
- FWCI
- 24.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P01CA087969, [P01 CA87969)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- breast cancer risk, alcohol consumption, binge drinking, drinking frequency, moderate drinking, women, Nurses' Health Study
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Alcohol Drinking, Ethanol, Central Nervous System Stimulants, Breast Neoplasms, Dose-Response Relationship, Drug, Estrogens, Female, Humans, Middle Aged, Prospective Studies, Receptors, Estrogen, Risk Assessment, Young Adult
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