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Cited by 880Probiotics and Fermented FoodsGut microbiota and healthGastrointestinal motility and disorders

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea: A Systematic Review and Meta-analysis

Newberry, Sydne J.·2012·JAMA
DOI 10.1001/jama.2012.3507
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Abstract

CONTEXT: Probiotics are live microorganisms intended to confer a health benefit when consumed. One condition for which probiotics have been advocated is the diarrhea that is a common adverse effect of antibiotic use. OBJECTIVE: To evaluate the evidence for probiotic use in the prevention and treatment of antibiotic-associated diarrhea (AAD). DATA SOURCES: Twelve electronic databases were searched (DARE, Cochrane Library of Systematic Reviews, CENTRAL, PubMed, EMBASE, CINAHL, AMED, MANTIS, TOXLINE, ToxFILE, NTIS, and AGRICOLA) and references of included studies and reviews were screened from database inception to February 2012, without language restriction. STUDY SELECTION: Two independent reviewers identified parallel randomized controlled trials (RCTs) of probiotics (Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, and/or Bacillus) for the prevention or treatment of AAD. DATA EXTRACTION: Two independent reviewers extracted the data and assessed trial quality. RESULTS: A total of 82 RCTs met inclusion criteria. The majority used Lactobacillus-based interventions alone or in combination with other genera; strains were poorly documented. The pooled relative risk in a DerSimonian-Laird random-effects meta-analysis of 63 RCTs, which included 11 811 participants, indicated a statistically significant association of probiotic administration with reduction in AAD (relative risk, 0.58; 95% CI, 0.50 to 0.68; P < .001; I(2), 54%; [risk difference, -0.07; 95% CI, -0.10 to -0.05], [number needed to treat, 13; 95% CI, 10.3 to 19.1]) in trials reporting on the number of patients with AAD. This result was relatively insensitive to numerous subgroup analyses. However, there exists significant heterogeneity in pooled results and the evidence is insufficient to determine whether this association varies systematically by population, antibiotic characteristic, or probiotic preparation. CONCLUSIONS: The pooled evidence suggests that probiotics are associated with a reduction in AAD. More research is needed to determine which probiotics are associated with the greatest efficacy and for which patients receiving which specific antibiotics.

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Metadata

Authors
Newberry, S. J.
Affiliations
RAND Corporation (US)
Corresponding author
Newberry, Sydne J.
ORCID
Newberry, Sydne J.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2012-05-09
Volume
307
Issue
18
Pages
1959
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.2012.3507
OpenAlex
W1966875539
Cited by
870
References
92
Citations by year
2026: 36 · 2025: 51 · 2024: 49 · 2023: 49 · 2022: 75 · 2021: 64 · 2020: 52 · 2019: 71 · 2018: 42 · 2017: 50 · 2016: 64 · 2015: 90 · 2014: 66 · 2013: 78 · 2012: 32
FWCI
130.56
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (290-2007-10062-I)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
probiotics, antibiotic-associated diarrhea, diarrhea prevention, Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, Bacillus, antibiotic adverse effects, probiotic efficacy
MeSH terms
Anti-Bacterial Agents, Diarrhea, Humans, Randomized Controlled Trials as Topic, Probiotics

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