Effect of Oxytocin on Placebo Analgesia: A Randomized Study
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Most reports have not demonstrated any specific antinociceptive properties for oxytocin.
“Most reports have not demonstrated any specific antinociceptive properties for oxytocin 23, 24, 25, including a phase 1 open‐label trial using intrathecal administration 26.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [24]
Double-blind, placebo-controlled studies have produced mixed results regarding the analgesic role of oxytocin in humans.
“However, double‐blind, placebo‐controlled studies have produced mixed results.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [24]
Because 70% of the sample in Rash and Campbell correctly identified the treatment they received, the observed analgesic effects of oxytocin could have been partially a result of the potentiating effects of oxytocin on placebo analgesia.
“However, because 70% of the sample correctly identified the treatment that they received (possibly as a result of the use of a saline spray as placebo), the observed analgesic effects of oxytocin could have been partially a result of the potentiating effects of oxytocin on placebo analgesia 24.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [24]
Experimental studies on healthy volunteers using acute noxious electrical, contact heat and cold-pressor stimuli have produced conflicting results on oxytocin antinociception.
“Experimental studies on healthy volunteers using acute noxious electrical, contact heat and cold‐pressor stimuli have produced further conflicting results.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [24]
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References 6 · Cited by 114
- Authors
- Kessner, S., Sprenger, C., Wrobel, N., Wiech, K., & Bingel, U.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Bath (GB)
- Essen University Hospital (DE)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2013-10-23
- Volume
- 310
- Issue
- 16
- Pages
- 1733
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2075807537
- Cited by
- 114
- References
- 6
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 11 · 2021: 3 · 2020: 13 · 2019: 13 · 2018: 16 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 10
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- oxytocin, placebo analgesia, placebo effect, analgesia
- MeSH terms
- Administration, Intranasal, Administration, Topical, Adult, Analgesics, Double-Blind Method, Empathy, Humans, Male, Oxytocin, Pain Measurement, Placebo Effect, Trust, Young Adult, Pain Perception
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