The DOI matches its Crossref record; 38 of the 43 references it cites were found in a registry or an index.
Quality of Life After PCI vs CABG Among Patients With Diabetes and Multivessel Coronary Artery Disease: A Randomized Clinical Trial
Open accessAbstract
IMPORTANCE: The FREEDOM trial demonstrated that among patients with diabetes mellitus and multivessel coronary artery disease, coronary artery bypass graft (CABG) surgery resulted in lower rates of death and myocardial infarction but a higher risk of stroke when compared with percutaneous coronary intervention (PCI) using drug-eluting stents. Whether there are treatment differences in health status, as assessed from the patient's perspective, is unknown. OBJECTIVES: To compare the relative effects of CABG vs PCI using drug-eluting stents on health status among patients with diabetes mellitus and multivessel coronary artery disease. DESIGN, SETTING, AND PARTICIPANTS: Between 2005 and 2010, 1900 patients from 18 countries with diabetes mellitus and multivessel coronary artery disease were randomized to undergo either CABG surgery (n = 947) or PCI (n = 953) as an initial treatment strategy. Of these, a total of 1880 patients had baseline health status assessed (935 CABG, 945 PCI) and comprised the primary analytic sample. INTERVENTIONS: Initial revascularization with CABG surgery or PCI. MAIN OUTCOMES AND MEASURES: Health status was assessed using the angina frequency, physical limitations, and quality-of-life domains of the Seattle Angina Questionnaire at baseline, at 1, 6, and 12 months, and annually thereafter. For each scale, scores range from 0 to 100 with higher scores representing better health. The effect of CABG surgery vs PCI was evaluated using longitudinal mixed-effect models. RESULTS: At baseline, mean (SD) scores for the angina frequency, physical limitations, and quality-of-life subscales of the Seattle Angina Questionnaire were 70.9 (25.1), 67.3 (24.4), and 47.8 (25.0) for the CABG group and 71.4 (24.7), 69.9 (23.2), and 49.2 (25.7) for the PCI group, respectively. At 2-year follow-up, mean (SD) scores were 96.0 (11.9), 87.8 (18.7), and 82.2 (18.9) after CABG and 94.7 (14.3), 86.0 (19.3), and 80.4 (19.6) after PCI, with significantly greater benefit of CABG on each domain (mean treatment benefit, 1.3 [95% CI, 0.3-2.2], 4.4 [95% CI, 2.7-6.1], and 2.2 [95% CI, 0.7-3.8] points, respectively; P < .01 for each comparison). Beyond 2 years, the 2 revascularization strategies provided generally similar patient-reported outcomes. CONCLUSIONS AND RELEVANCE: For patients with diabetes and multivessel CAD, CABG surgery provided slightly better intermediate-term health status and quality of life than PCI using drug-eluting stents. The magnitude of benefit was small, without consistent differences beyond 2 years, in part due to the higher rate of repeat revascularization with PCI. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00086450.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There was also a small favorable benefit in quality of life favoring CABG from 6 months to 2 years, although there was no further accrual of benefit beyond 2 years.294”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [294]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Serruys, P., de Jaegere, P., Kiemeneij, F., Macaya, C., Rutsch, W., Heyndrickx, G., Emanuelsson, H., Marco, J., Legrand, V., & Materne, P. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408253310801 · Cited by 4,695
Serruys, P., Morice, M., Kappetein, A., Colombo, A., Holmes, D., Mack, M., Ståhle, E., Feldman, T., van den Brand, M. V. D., Bass, E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804626 · Cited by 4,142
Strategies for Multivessel Revascularization in Patients with Diabetes
Farkouh, M. E., Domanski, M., Sleeper, L. A., Siami, F. S., Dangas, G., Mack, M., Yang, M., Cohen, D. J., Rosenberg, Y., Solomon, S. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211585 · Cited by 1,922
Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease.
Bourassa, M., Frye, R., King, S., Detre, K., Alderman, E., Andrews, K., & Sopko, G. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607253350401 · Cited by 1,489
Spertus, J., Winder, J. A., Dewhurst, T. A., Deyo, R., Prodzinski, J., McDonnell, M., & Fihn, S. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00397-9 · Cited by 1,413
Unbalanced repeated-measures models with structured covariance matrices.
Jennrich, R., & Schluchter, M. (1986) · Biometrics · doi:10.2307/2530695 · Cited by 1,382
Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease.
Serruys, P., Unger, F., Sousa, J., Jatene, A., Bonnier, H., Schönberger, J. P. M. A., Buller, N., Bonser, R., van den Brand, M. V. D., van Herwerden, L. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441502 · Cited by 1,204
Appointment of New Associate Editor for Circulation
Willerson, J. (1996) · Circulation · doi:10.1161/01.cir.94.6.1193 · Cited by 918
Everolimus-eluting versus paclitaxel-eluting stents in coronary artery disease.
Stone, G., Rizvi, A., Newman, W., Mastali, K., Wang, J., Caputo, R. P., Doostzadeh, J., Cao, S., Simonton, C., Sudhir, K., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0910496 · Cited by 907
Effect of PCI on Quality of Life in Patients with Stable Coronary Disease
Weintraub, W. S., Spertus, J. A., Kolm, P., Maron, D. J., Zhang, Z., Jurkovitz, C. T., Zhang, W., Hartigan, P. M., Lewis, C., Veledar, E., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072771 · Cited by 738
Kedhi, E., Joesoef, K. S., Mcfadden, E., Wassing, J., Mieghem, C. V., Goedhart, D., & Smits, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62127-9 · Cited by 717
Serruys, P., Ong, A. T. L., van Herwerden, L. A., Sousa, J., Jatene, A., Bonnier, J., Schönberger, J. P. M. A., Buller, N., Bonser, R., Disco, C., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.082 · Cited by 657
Health Status Predicts Long-Term Outcome in Outpatients With Coronary Disease
Spertus, J., Jones, P. G., McDonell, M., Fan, V., & Fihn, S. (2002) · Circulation · doi:10.1161/01.cir.0000020688.24874.90 · Cited by 528
Kapur, A., Hall, R., Malik, I., Qureshi, A., Butts, J. N., de Belder, M. D., Baumbach, A., Angelini, G., de Belder, A. D., Oldroyd, K., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.014 · Cited by 497
Hoffman, S. N., Tenbrook, J., Wolf, M. P., Pauker, S., Salem, D., & Wong, J. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00157-8 · Cited by 455
Monitoring the quality of life in patients with coronary artery disease.
Spertus, J. A., Winder, J. A., Dewhurst, T. A., Deyo, R., & Fihn, S. D. (1994) · American Journal of Cardiology · doi:10.1016/0002-9149(94)90555-x · Cited by 435
Preferences for quality of life or survival expressed by patients with heart failure
Lewis, E. F., Johnson, P. A., Johnson, W., Collins, C., Griffin, L., & Stevenson, L. W. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(01)00298-4 · Cited by 433
Hlatky, M. A., Rogers, W. J., Johnstone, I. M., Boothroyd, D. B., Brooks, M. M., Pitt, B., Reeder, G. S., Ryan, T., Smith, H. M., Whitlow, P. L., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701093360203 · Cited by 326
Quality of Life after PCI with Drug-Eluting Stents or Coronary-Artery Bypass Surgery
Cohen, D. J., Van Hout, B., Serruys, P. W., Mohr, F. W., Macaya, C., den Heijer, P., Vrakking, M. M., Wang, K., Mahoney, E. M., Audi, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1001508 · Cited by 288
Legrand, V., Serruys, P., Unger, F., van Hout, B., Vrolix, M., Fransen, G., Nielsen, T., Paulsen, P. K., Gomes, R., Melo, J. M. G. D. Q. E., et al. (2004) · Circulation · doi:10.1161/01.cir.0000118504.61212.4b · Cited by 246
Henderson, R., Pocock, S., Sharp, S., Nanchahal, K., Sculpher, M., Buxton, M., & Hampton, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03358-3 · Cited by 244
Bangalore, S., Kumar, S. K., Fusaro, M. V., Amoroso, N., Kirtane, A., Byrne, R., Williams, D., Slater, J., Cutlip, D., & Feit, F. (2012) · British medical journal · doi:10.1136/bmj.e5170 · Cited by 230
Evidence for Use of Coronary Stents: A Hierarchical Bayesian Meta-Analysis
Brophy, J., Belisle, P., & Joseph, L. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-10-200305200-00005 · Cited by 208
Strategies for multivessel revascularization in patients with diabetes.
Lee, J.-H., & Lee, S.-W. (2013) · Journal of Comparative Effectiveness Research · doi:10.2217/cer.13.21 · Cited by 197
Farkouh, M. E., Dangas, G., Leon, M. B., Smith, C. R., Nesto, R. W., Buse, J. B., Cohen, D. J., Mahoney, E. M., Sleeper, L. A., King, S. B., et al. (2008) · American Heart Journal · doi:10.1016/j.ahj.2007.10.012 · Cited by 190
Quantifying and predicting recovery after heart surgery.
Jenkins, C., Stanton, B., & Jono, R. T. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199405000-00005 · Cited by 123
Magnuson, E., Farkouh, M., Fuster, V., Wang, K.-J., Vilain, K. A., Li, H., Appelwick, J., Muratov, V., Sleeper, L., Boineau, R., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.147488 · Cited by 122
Self-citationRose, J., O'Toole, E., Dawson, N., Lawrence, R., Gurley, D., Thomas, C. L., Hamel, M., & Cohen, H. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.050 · Cited by 119
Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D).
Sinha, A. (2013) · doi:10.1016/j.ihj.2013.04.027 · Cited by 104
Zhang, Z.-F., Mahoney, E., Stables, R., Booth, J., Nugara, F., Spertus, J., & Weintraub, W. (2003) · Circulation · doi:10.1161/01.cir.0000087600.83707.fd · Cited by 102
Höfer, S., Benzer, W., Schüßler, G., von Steinbüchel, N., & Oldridge, N. (2003) · Quality of Life Research · doi:10.1023/a:1022272620947 · Cited by 91
Borkon, A., Muehlebach, G., House, J., Marso, S., & Spertus, J. (2002) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04063-8 · Cited by 84
Arnold, S., Spertus, J., Jones, P. G., Xiao, L., & Cohen, D. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.03.021 · Cited by 65
Cleary, P., Epstein, A. M., Oster, G., Morrissey, G., Stason, W. B., Debussey, S., Plachetka, J., & Zimmerman, M. (1991) · Medical Care · doi:10.1097/00005650-199110000-00001 · Cited by 65
Brooks, M. M., Chung, S., Helmy, T. A., Hillegass, W. B., Escobedo, J., Melsop, K. A., Massaro, E. M., McBane, R. D., Hyde, P., Hlatky, M. A., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.912642 · Cited by 45
Arnold, S., Magnuson, E., Wang, K.-J., Serruys, P., Kappetein, A., Mohr, F., & Cohen, D. J. (2012) · Circulation. Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.111.964585 · Cited by 36
Compelling evidence for coronary-bypass surgery in patients with diabetes.
Hlatky, M. (2012) · New England Journal of Medicine · doi:10.1056/nejme1212278 · Cited by 32
Evidence for use of coronary stents.
Massel, D. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-2-200401200-00032-w1 · Cited by 8
Cited by
Sorted by citations
2018 ESC/EACTS guidelines on myocardial revascularization
Neumann, F.-J., Sousa-Uva, M., Ahlsson, A., Alfonso, F., Banning, A. P., Benedetto, U., Byrne, R. A., Collet, J.-P., Falk, V., Head, S. J., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy394 · Cited by 7,167
2014 ESC/EACTS Guidelines on myocardial revascularization
Kolh, P. H., Windecker, S., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu366 · Cited by 4,217
2018 ESC/EACTS Guidelines on myocardial revascularization
Sousa-Uva, M., Neumann, F., Ahlsson, A., Alfonso, F., BANNING, A. P., Benedetto, U., Byrne, R. A., Collet, J., Falk, V., Head, S. J., et al. (2018) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezy289 · Cited by 1,025
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001168 · Cited by 1,598
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
Lawton, J. S., Tamis‐Holland, J. E., Bangalore, S., Bates, E., Beckie, T. M., Bischoff, J. M., Bittl, J. A., Cohen, M. G., DiMaio, J. M., Don, C. W., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.09.006 · Cited by 1,691
Metadata
- Authors
- Abdallah, M. S.
- Affiliations
- Saint Luke's Hospital (US)
- Corresponding author
- Abdallah, Mouin S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2013-10-16
- Volume
- 310
- Issue
- 15
- Pages
- 1581
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC4370776
- OpenAlex
- W2025139632
- Cited by
- 169
- References
- 43
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 6 · 2023: 9 · 2022: 16 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 17 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 1
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01 01HL071988, R01HL092989, P50HL077113, U01HL071988, U01 01HL092989)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- coronary artery bypass grafting, percutaneous coronary intervention, drug-eluting stents, diabetes mellitus, multivessel coronary artery disease, quality of life, Seattle Angina Questionnaire, angina frequency, physical limitations, health status, FREEDOM trial, revascularization, patient-reported outcomes, stroke risk, myocardial infarction, mortality
- MeSH terms
- Aged, Angina Pectoris, Coronary Artery Bypass, Coronary Artery Disease, Diabetes Mellitus, Female, Health Status, Humans, Male, Middle Aged, Quality of Life, Treatment Outcome, Diabetes Complications, Drug-Eluting Stents, Percutaneous Coronary Intervention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
