Cited by 630Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Open access

Dysken, Maurice W., Sano, Mary, Asthana, Sanjay, Vertrees, Julia E., Pallaki, Muralidhar, Llorente, Maria, Love, Susan, Schellenberg, Gerard D., McCarten, J. Riley, Malphurs, Julie, Prieto, Susana, Chen, Peijun, Loreck, David J., Trapp, George, Bakshi, Rajbir S., Mintzer, Jacobo E., Heidebrink, Judith L., Vidal-Cardona, Ana, Arroyo, Lillian M., Cruz, Angel R., Zachariah, Sally, Kowall, Neil W., Chopra, Mohit P., Craft, Suzanne, Thielke, Stephen, Turvey, Carolyn L., Woodman, Catherine, Monnell, Kimberly A., Gordon, Kimberly, Tomaska, Julie, Segal, Yoav, Peduzzi, Peter N., Guarino, Peter D.·2014·JAMA

DOI 10.1001/jama.2013.282834PMC PMC4109898

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Although vitamin E and memantine have been shown to have beneficial effects in moderately severe Alzheimer disease (AD), evidence is limited in mild to moderate AD. OBJECTIVE: To determine if vitamin E (alpha tocopherol), memantine, or both slow progression of mild to moderate AD in patients taking an acetylcholinesterase inhibitor. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, placebo-controlled, parallel-group, randomized clinical trial involving 613 patients with mild to moderate AD initiated in August 2007 and concluded in September 2012 at 14 Veterans Affairs medical centers. INTERVENTIONS: Participants received either 2000 IU/d of alpha tocopherol (n = 152), 20 mg/d of memantine (n = 155), the combination (n = 154), or placebo (n = 152). MAIN OUTCOMES AND MEASURES: Alzheimer's Disease Cooperative Study/Activities of Daily Living (ADCS-ADL) Inventory score (range, 0-78). Secondary outcomes included cognitive, neuropsychiatric, functional, and caregiver measures. RESULTS: Data from 561 participants were analyzed (alpha tocopherol = 140, memantine = 142, combination = 139, placebo = 140), with 52 excluded because of a lack of any follow-up data. Over the mean (SD) follow-up of 2.27 (1.22) years, ADCS-ADL Inventory scores declined by 3.15 units (95% CI, 0.92 to 5.39; adjusted P = .03) less in the alpha tocopherol group compared with the placebo group. In the memantine group, these scores declined 1.98 units less (95% CI, -0.24 to 4.20; adjusted P = .40) than the placebo group's decline. This change in the alpha tocopherol group translates into a delay in clinical progression of 19% per year compared with placebo or a delay of approximately 6.2 months over the follow-up period. Caregiver time increased least in the alpha tocopherol group. All-cause mortality and safety analyses showed a difference only on the serious adverse event of "infections or infestations," with greater frequencies in the memantine (31 events in 23 participants) and combination groups (44 events in 31 participants) compared with placebo (13 events in 11 participants). CONCLUSIONS AND RELEVANCE: Among patients with mild to moderate AD, 2000 IU/d of alpha tocopherol compared with placebo resulted in slower functional decline. There were no significant differences in the groups receiving memantine alone or memantine plus alpha tocopherol. These findings suggest benefit of alpha tocopherol in mild to moderate AD by slowing functional decline and decreasing caregiver burden. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00235716.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2013.282834

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568
A sharper Bonferroni procedure for multiple tests of significance
HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829
A new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Self-citation
Memantine in Moderate-to-Severe Alzheimer's Disease
Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043

Show all 40 references

Sorted by citations

Items 401–500 of 630

Oxidative stress in chronic disease: Mechanisms, therapeutic strategies, and future directions
Rahman, S. Z., Konok, F. A., Maliyet, C. F., Mia, M. F., Rahman, T., & Rahman, A. (2026) · Advances in Redox Research · doi:10.1016/j.arres.2026.100177 · Cited by 6
Neurodegenerative Etiology of Aromatic L-Amino Acid Decarboxylase Deficiency: a Novel Concept for Expanding Treatment Strategies
Sternberg, Z. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03684-2 · Cited by 6
Gene co-expression patterns shared between chemobrain and neurodegenerative disease models in rodents
Zare, M.-S., Abedpoor, N., Hajibabaie, F., & Walker, A. K. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106944 · Cited by 6
The role of periodontitis in the link between alpha-tocopherol intake and cognitive performance: A mediation analysis in older adults
Zhang, H., Sun, L., Zhang, L., Li, J., Liu, Y., Chen, Z., Wang, S., Gao, C., & Sun, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1129095 · Cited by 5
Novel therapeutic approaches for targeting Alzheimer’s disease
Khodakiya, A., Chaudhary, S., Chaudhary, A., & Prajapati, B. G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13205-6.00020-0 · Cited by 5
Prevention of Cognitive Decline
Gutierrez, J., & Isaacson, R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3106-0_12 · Cited by 5
Benefits and Risks of Add-On Therapies for Alzheimer’s Disease
Magierski, R., & Sobów, T. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.15.39 · Cited by 6
Neuroprotection in Alzheimer Disease
Jain, K. K. (2019) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-4939-9465-6_8 · Cited by 5
Iron and Alzheimer’s Disease
Lo, Y. L., & Cheng, S. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-7327-7_7 · Cited by 5
Oral and enteral nutrition in dementia: an overview
Brooke, J. M., & Ojo, O. (2015) · British Journal of Nursing · doi:10.12968/bjon.2015.24.12.624 · Cited by 5
An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial
Lopresti, A. L., Smith, S. J., Ding, L., Li, Y., & Zhang, P. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1621516 · Cited by 4
Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis
Evans, R. C., Dar, N. J., Chen, L., Na, R., O’Connor, J. C., Jiang, J., Zheng, S., & Ran, Q. (2025) · Aging Cell · doi:10.1111/acel.70218 · Cited by 4
Repurposing approved drugs as ferroptosis modulators: a critical review of clinical trials in cancer and neurodegeneration
Zayed, M., Massoud, A., Elwakeel, E., Ezzat, P., Alammar, Y., El-Wahab, N. A. A., Afifi, R. W., & Jeong, B. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05582-5 · Cited by 5
Hypolipidemic effect and antioxidant properties of cassava-wheat flour composite bread in rats
Ajani, R. A., Adefegha, S. A., & Oboh, G. (2022) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-022-01600-1 · Cited by 4
Alzheimer’s Disease and Other Dementias
Neel, I. C. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_84 · Cited by 4
Alzheimer’s Disease: An Epidemiologic Disaster From Nutritional Perspective
Péter, S. (2017) · Journal of Nutritional Health & Food Science · doi:10.15226/jnhfs.2017.00184 · Cited by 4
Preventive and Risk Factors of Canine Dementia
Maďari, A., Farbáková, J., & Žilka, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-53219-6_9 · Cited by 4
Dieta y prevención en enfermedad de Alzheimer
Arizaga, R. L., Barreto, D., Bavec, C. V., Berríos, W., Cristalli, D. O., Colli, L. P., Garau, M. L., Golimstok, Á., Ollari, J., & Sarasola, D. (2018) · Neurología Argentina · doi:10.1016/j.neuarg.2017.11.002 · Cited by 8
Rolle der Vitamine im Alter – Evidenz und praktische Umsetzung
Weber, P. (2018) · Ernährung & Medizin · doi:10.1055/s-0044-101056 · Cited by 4
[Vitamin E reduces radiation injury of hippocampal neurons in mice by inhibiting ferroptosis].
Ren, C., Li, X., & Du, S. (2020) · PubMed Central · doi:10.12122/j.issn.1673-4254.2020.08.05 · Cited by 4
Efectos del uso del 17 β-estradiol y la genisteína en la enfermedad de Alzheimer en mujeres con menopausia
Chávez-Pérez, C., Ceballos-Ramírez, A., & Suárez-Castro, A. (2021) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2021.04.005 · Cited by 4
Neuroprotective effect of low-dose paracetamol treatment against cognitive dysfunction in d-galactose-induced aging mice
Lalert, L., le-Grand, S. M., Techarang, T., Huntula, S., & Punsawad, C. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11108 · Cited by 4
Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease
Doroszkiewicz, J., Mroczko, J., Rutkowski, P., & Mroczko, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310751 · Cited by 4
Alzheimer’s Disease: Treatment Today and Tomorrow
Gorthi, S. P., & Gupta, D. (2023) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_254_23 · Cited by 4
History of Vitamin E Research
Birringer, M., Blumberg, J. B., Eggersdorfer, M. L., Frank, J., & Weber, P. (2019) · Springer eBooks · doi:10.1007/978-3-030-05315-4_2 · Cited by 4
Vitamins and Cognition: A Nutrigenomics Perspective
Anitha, A., Viswambharan, V., Thanseem, I., Iype, M., Parakkal, R., Surendran, S. P., & Vasu, M. M. (2020) · Current Nutrition & Food Science · doi:10.2174/1573401316999200901180443 · Cited by 4
Consumption of a multivitamin/multimineral supplement for 4 weeks improves nutritional status and markers of cardiovascular health
Levy, M. A., McKinnon, T., Goldfine, H., Enomoto, A. C., Schneider, E. D., & Cuomo, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103511 · Cited by 5
Death Toll by Dementia DrugPreprint
Lee, J.-H. (2021) · Research Square · doi:10.21203/rs.3.rs-384861/v4
The Preventive and Treatment of the Neuro-Inflammasome in Sorokdo National HospitalPreprint
Lee, J., Lee, C. J., Park, J., Lee, S. J., Choi, S.-H., & Oh, S.-S. (2021) · Research Square · doi:10.21203/rs.3.rs-243831/v1 · Cited by 4
Vitamin E and cognitive function: A systematic review of clinical evidence
Amin, A. M., & Mostafa, H. M. A. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.11.009 · Cited by 4
Targeting pyroptosis in tauopathies: A redox-driven axis of neuroinflammation and neurodegeneration
López, E. A., Silva-Llanes, I., Diez-Tejedor, E., & Lastres‐Becker, I. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.04.029 · Cited by 4
Management of Alzheimer’s Disease with nutraceuticals
Yadav, J. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00028-8 · Cited by 3
A meta‐analysis and systematic review of interventions to prevent or treat cognitive decline related to Alzheimer's disease in adults with Down syndrome
Munn, E. E., Montelongo, A., Patel, V. K., Fodstad, J. C., Ciccarelli, M. R., Ptomey, L. T., & Pangelinan, M. M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70471 · Cited by 2
Role of Nutraceuticals in Dementia Care
Ford, J. M., & Brandt, N. (2014) · Journal of Gerontological Nursing · doi:10.3928/00989134-20140304-99 · Cited by 3
Treatment of Dementia: Pharmacological Approaches
Brandt, N., & Mansour, D. Z. (2015) · Springer eBooks · doi:10.1007/978-3-319-18377-0_6 · Cited by 2
Vitamin E and Mortality: A Critical Perspective of the Conflicting Meta-analysis Outcomes
Köpcke, W. (2019) · Springer eBooks · doi:10.1007/978-3-030-05315-4_17 · Cited by 3
Alzheimer Hastalığı ve Anti-Alzheimer Etkili Bileşiklerin Yapılarının Araştırılması
Tari, O., & YAĞMURTAŞAN, R. (2023) · Hacettepe University Journal of the Faculty of Pharmacy · doi:10.52794/hujpharm.1175099 · Cited by 3
Beneficial effects of nutraceuticals in healthy brain aging
Dkhar, P., & Sharma, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00009-4 · Cited by 3
Improvement of cognitive performance by a nutraceutical formulation: Underlying mechanisms revealed by laboratory studies
Shea, T. B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.039 · Cited by 3
Alzheimer’s Disease
Puerto, A. M. H., Russo, C., & Fregni, F. (2018) · Neuromethods · doi:10.1007/978-1-4939-7880-9_9 · Cited by 5
Biochemical and Radiological Markers of Alzheimer’s Disease Progression
Dziedzic, T., Pera, J., Klimkowicz‐Mrowiec, A., Mroczko, B., & Słowik, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/ifs-150578 · Cited by 3
Memantine and Alzheimer's disease
del Río‐Sancho, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815854-8.00032-x · Cited by 3
Nutrients’ Role in the Treatment of Parkinson’s and Alzheimer’s Diseases
Aavula, T., Vignesh, N., & Saravanan, R. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-8158-5_12 · Cited by 3
Complementary and Alternative Medicine Approaches in Alzheimer Disease and Other Neurocognitive Disorders.
Beversdorf, D. Q., Crosby, H. W., & Shenker, J. I. (2023) · PubMed Central · Cited by 3
Alzheimer's Disease and Mild Cognitive Impairment
Jones, D. T., Bruns, M. B., & Petersen, R. C. (2018) · Wiley eBooks · doi:10.1002/9781118772034.ch21 · Cited by 3
Mitochondrial Function and Neurodegenerative Diseases
Wilkins, H. M., Weidling, I., Koppel, S., Wang, X., von Schulze, A., & Swerdlow, R. H. (2018) · The Molecular and Cellular Basis of Neurodegenerative Diseases · doi:10.1016/b978-0-12-811304-2.00013-4 · Cited by 2
Cognitive Enhancers and Treatments for Alzheimer’s Disease
Devanand, D. P., & Fremont, R. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_139-1 · Cited by 3
Epigenetic modulations and nutrient interactions in Alzheimer's disease: unveiling potential therapeutic pathways
Zainuddin, M.-S., Ghanesh, K., Ganesan, N., Kumari, M., Radhakrishnan, A. K., & Bhuvanendran, S. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2526155 · Cited by 2
The role of vitamins in dementia prevention and cognitive health: A comprehensive review
Ahmed, A., Khan, H., Shah, S. S. U. D., Kiyani, M. M., Al‐Hussain, F., Bashir, S., Fu, X., & Li, P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251379700 · Cited by 2
Low‐Dose Paracetamol Treatment Protects Neuronal Oxidative Stress and Neuroinflammation in D‐Galactose‐Induced Accelerated Aging Model
Punsawad, C., Kaewman, P., Techarang, T., Sketriené, D., & Lalert, L. (2025) · Scientifica · doi:10.1155/sci5/5559483 · Cited by 2
A brain-computer interface roadmap for diagnosing and treating neurological disorders
Sun, G., Wang, Y., Liu, H., Weng, L., Li, X., He, W., Sun, J., Liang, S., Kong, W., Dong, J.-Z., et al. (2025) · The Innovation Informatics · doi:10.59717/j.xinn-inform.2025.100016 · Cited by 2
Interpretable machine learning models for predicting cognitive impairment using NHANES neuropsychological tests: nutritional and sociodemographic associations
Song, L., Li, C., Xiang, X., & Lin, P. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1680290 · Cited by 2
A Narrative Review of Dietary, Lifestyle, and Other Complementary and Alternative Approaches in Alzheimer’s Disease and Related Dementias
Musich, M. L., Shenker, J. I., & Beversdorf, D. Q. (2026) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad3010004 · Cited by 2
Vitamin deficiencies and Alzheimer’s disease: evidence and implications for supplementation
Miteva, M. T., Laurenti, D., Mattioli, R., Risola, D. D., Mariano, A., & Mosca, L. N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1676497 · Cited by 2
Vitamins as Modulators of Neurodegenerative Disease Pathways: Mechanisms and Therapeutic Perspectives
Kwaśniewska, K., Fic, W., & Polak-Szczybyło, E. (2026) · Nutrients · doi:10.3390/nu18060995 · Cited by 2
Aktuelle Therapieoptionen bei Demenz
Gutzmann, H. (2014) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-014-0812-z · Cited by 1
Vitamin E zögert die Alzheimer-Progression nur ganz leicht hinaus
Hermann, D. M. (2014) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-014-3161-0 · Cited by 2
Utilization of Observational Data as a Proxy Cohort for Comparison Purposes with Open-Label Study Results: An Example from Alzheimer's Disease
Reed, C. C., Happich, M., Raskin, J., Tockhorn‐Heidenreich, A., & Belger, M. A. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.4 · Cited by 2
Alzheimer Disease
Коган, М. И., & Jeong, H.-S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00011-6 · Cited by 2
Medicinal Herbs and Nutritional Supplements for Dementia Therapy: Potential Targets and Clinical Evidence
Dorman, G. S., Flores, I., Gutiérrez, C., Castaño, R. F., Aldecoa, M., & Kim, L. M. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210809121230 · Cited by 3
α-Tocopherol for Alzheimer's disease
Ayoub, N. M., Khalil, R., & Kaddoumi, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89835-5.00015-6 · Cited by 2
Nutrition and neurodegenerative diseases: Alzheimer's disease and others
Bianchi, V. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91747-6.00013-5 · Cited by 2
Diabetes Mellitus: Exploring Biomarkers, Complications, and Therapeutic Strategies with a Spotlight on Cyanobacterial Bioactive Compounds - A Comprehensive Review
Ahmad, S., Akhtar, S., Kamal, M. A., & Farooqui, A. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998307764240909114007 · Cited by 2
Role of nutraceuticals in neurological disease
Garg, A. K., Garg, S., Singh, V., Rai, G., Pandey, P., & Mishra, N. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00018-3 · Cited by 2
Insufficient evidence for vitamin E in Alzheimer's disease
Hermann, D. M. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.08.003 · Cited by 2
Lipids and Health
Leray, C. (2020) · OCL · doi:10.1051/ocl/2020018 · Cited by 2
Older Veterans
Little, J. T., Llorente, B. A., & Llorente, M. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-05384-0_17 · Cited by 2
DTB Select: 3 | March 2014
(2014) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2014.3.0239 · Cited by 2
阿尔茨海默病脑健康营养干预专家共识
Shi, H., & Xu, J. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0196 · Cited by 3
Cognitive Enhancers and Treatments for Alzheimer’s Disease
Devanand, D. P., & Fremont, R. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_139 · Cited by 3
Nutrition and Cognition
Perkisas, S., & Vandewoude, M. F. J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316677018.013 · Cited by 2
Prescribing in Older People
(2021) · Wiley eBooks · doi:10.1002/9781119870203.mpg006 · Cited by 2
Gesundheitskompetenz in vulnerablen Bevölkerungsgruppen
al., S. E. (2018) · Monitor Versorgungsforschung · doi:10.24945/mvf.05.18.1866-0533.2111 · Cited by 1
Nutritional strategies against dementia in rural populations
Gonçalves, B. D. S., Gannavaram, N. L., Yates, C., Kandula, A., Nayyar, A., Pillai, S. S., Puri, R. K., & Nayyar, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1677197 · Cited by 1
Vitamin E and melatonin synergistically attenuate sleep deprivation-induced Nrf2 dysregulation and hippocampal ferroptosis in Alzheimer's disease mouse models
Gao, Q., Sun, J., Hei, B., Zhou, J., Wang, B., Wang, D., Hu, S., Liu, J., Wang, D., & Fan, J. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115781 · Cited by 1
Nutrients and bioactive compounds as modifiers of neurodegenerative trajectories: molecular mechanisms, translational barriers, and precision nutrition
Singh, G., Singh, G., Shreya, Kumari, A., & Aran, K. R. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1819432 · Cited by 1
Efficacy of antioxidants as a therapy for Alzheimer's disease: a meta-analysis
Li, J., Chen, B., Jiang, J., Feng, Y., Zhang, R., Li, D. M., Wang, R., Long, Z., Ge, L., Guo, Y., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1878597 · Cited by 1
Oxidative stress and inflammation in neurodegenerative disorders
Jomová, K., Alomar, S. Y., Valko, R., Nepovimová, E., Kuča, K., & Valko, M. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04518-5 · Cited by 1
From Damage to Dysregulation: Reframing Oxidative Stress and Redox Homeostasis in Central Nervous System Disease
Lado, L. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188374 · Cited by 1
Vitamins: The Good, the Bad, and the Ugly
Morley, J. E. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.01.013 · Cited by 1
Pharmacological Treatment of Cognitive Symptoms in Alzheimer's Disease
Leguizamon, P. P., Dillon, C., Castro, D., Loñ, L., Guelar, V., & Taragano, F. E. (2014) · Current Psychopharmacologye · doi:10.2174/2211556003666140717184049 · Cited by 1
Vitamin E has Modest Benefit for Early AD
FitzGerald, S. F. (2014) · Neurology Today · doi:10.1097/01.nt.0000444717.40136.88 · Cited by 1
10 Neurocognitieve stoornissen
Verdonschot, T., & Kat, M. G. (2016) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-1312-9_10 · Cited by 1
Nutrition and Central Nervous System
Álvarez, S. M., Gómez, N. N., Navigatore-Fonzo, L., Sanchez, E. S., & Giménez, M. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-53126-7_35 · Cited by 1
Evaluation of an Evidence-based Medicine Educational Program for Pharmacists and Pharmacy Students
Shimizu, T., Ueda, M., Toyoyama, M., Ohmori, S., & Takagaki, N. (2018) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.17-00190-5 · Cited by 1
Management
Larner, A. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-75259-4_10 · Cited by 1
Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature
Dhingra, A. K., & Chopra, B. (2022) · The Natural Products Journal · doi:10.2174/2210315512666220627153553 · Cited by 1
Lipids and mental health
Chen, D. T.-L., Chen, J., Chang, J. P., & Su, K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823914-8.00021-5 · Cited by 1
Alzheimer’s Disease and Other Dementias
Neel, I. C. (2022) · Springer eBooks · doi:10.1007/978-3-030-01782-8_84-1 · Cited by 1
Chapter 8. Dementia and Mild Neurocognitive Disorders
Wise, E. A., & Lyketsos, C. G. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds08 · Cited by 1
The effect of antioxidants on the course and prevention of Alzheimer's disease on the example of vitamin E
Gawryś, A., Cholewa, M. M., Kromer, A., Wilk, J., Cichoń, K., Zapała, M. A., Łapaj, M., Chyćko, M., Środoń, A., & CZARNOTA, J. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.46.01.015 · Cited by 1
Precision Nutrition in Aging and Brain Health
Chen, S. T., & Small, G. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15315-0.00017-1 · Cited by 1
Manejo Farmacológico De Pacientes Com Doença De Alzheimer: Revisão Narrativa Da Literatura
Ghazzaoui, L. O., Bracelis, R. A. A., Freitas, R. D. B., Pinto, L. D. O., Balsimelli, R., Kehrwald-Balsimelli, B., de Góes, R. B., Miranda, M. N., da Silva, C. J., de Novais, M. A. P., et al. (2023) · Journal of Medical Residency Review · doi:10.37497/jmrreview.v2i1.53 · Cited by 1
Neurologic Disease and Anesthesia
Du, A., Culley, D. J., & Crosby, G. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93273-8.00025-0 · Cited by 1
The Next Pandemic
Haider, R. (2024) · Asian Journal of Pharmaceutical Research · doi:10.52711/2231-5691.2024.00011 · Cited by 1
Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians
Chan, J. P., Tanprasertsuk, J., Johnson, E. J., Dey, P., Bruno, R. S., Johnson, M. A., Poon, L. W., Davey, A., Woodard, J. L., & Kuchan, M. J. (2024) · Antioxidants · doi:10.3390/antiox13080997 · Cited by 1
Memantine in mild cognitive impairment and mild dementia of Alzheimer’s disease: theoretical background, clinical trials and recommendations
Sobów, T. (2014) · Aktualności Neurologiczne · doi:10.15557/an.2014.0006 · Cited by 1
Potential Treatment Strategies for Dementia With Pharmacological and Nonpharmacological Interventions
Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00007-6 · Cited by 1
Preventative medicine and Alzheimer’s disease: is Alzheimer’s disease risk reduction achievable?
Sinyor, B., Isaacson, R., & Ochner, C. N. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.306086 · Cited by 1
Nutritional Management in Dementia
Kang, J. (2021) · Journal of Clinical Nutrition · doi:10.15747/jcn.2021.13.1.1 · Cited by 1

Authors: Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., Prieto, S., Chen, P., Loreck, D. J., Trapp, G., Bakshi, R. S., Mintzer, J. E., Heidebrink, J. L., Vidal-Cardona, A., Arroyo, L. M., Cruz, A. R., Zachariah, S., Kowall, N. W., Chopra, M. P., Craft, S., Thielke, S., Turvey, C. L., Woodman, C., Monnell, K. A., Gordon, K., Tomaska, J., Segal, Y., Peduzzi, P. N., & Guarino, P. D.
Affiliations: Minneapolis VA Health Care System (US)
James J. Peters VA Medical Center (US)
William S. Middleton Memorial Veterans Hospital (US)
Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico
Louis Stokes Cleveland VA Medical Center (US)
Washington DC VA Medical Center (US)
University of Pennsylvania (US)
Miami VA Healthcare System (US)
VA Maryland Health Care System (US)
VA North Texas Health Care System (US)
Medical University of South Carolina (US)
VA Ann Arbor Healthcare System (US)
VA Caribbean Healthcare System, San Juan, Puerto Rico
VA Caribbean Healthcare System (PR)
Bay Pines VA Healthcare System (US)
VA Boston Healthcare System (US)
University of Washington (US)
University of Iowa (US)
W. G. (Bill) Hefner VA Medical Center (US)
Yale University (US)
ORCID: Sano, Mary
Asthana, Sanjay
Vertrees, Julia E.
Schellenberg, Gerard D.
McCarten, J. Riley
Chen, Peijun
Mintzer, Jacobo E.
Heidebrink, Judith L.
Kowall, Neil W.
Craft, Suzanne
Thielke, Stephen
Turvey, Carolyn L.
Woodman, Catherine
Tomaska, Julie
Peduzzi, Peter N.
Guarino, Peter D.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2014-01-01
Volume: 311
Issue: 1
Pages: 33
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2013.282834
PMC: PMC4109898
OpenAlex: W2128047032
Cited by: 628
References: 40
Citations by year: 2026: 34 · 2025: 41 · 2024: 36 · 2023: 54 · 2022: 56 · 2021: 53 · 2020: 47 · 2019: 47 · 2018: 61 · 2017: 48 · 2016: 50 · 2015: 55 · 2014: 44
FWCI: 35.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P50AG005138, P30AG013846, P50AG005136)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, vitamin E, alpha-tocopherol, memantine, functional decline, activities of daily living, acetylcholinesterase inhibitors, disease progression, caregiver burden, neuropsychiatric symptoms, adverse events, infections and infestations, combination therapy, veterans, older adults, cognitive decline, mortality, quality of life, cost-effectiveness
MeSH terms: Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Antioxidants, Cholinesterase Inhibitors, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Memantine, Middle Aged, Severity of Illness Index, Vitamin E, Dopamine Agents, Treatment Outcome, Caregivers, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks