Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population

Estrada, Karol, Aukrust, Ingvild, Bjørkhaug, Lise, Burtt, Noël P., Mercader, Josep M., García-Ortiz, Humberto, Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia +42 more·2014·JAMA
DOI 10.1001/jama.2014.6511

Cited by (262)

Items 201–262 of 262

  1. Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries
    J. Flannick, J. Mercader, C. Fuchsberger, M. Udler, A. Mahajan, J. Wessel, T. Teslovich, Lizz Caulkins, Ryan Koesterer, T. Blackwell et al. · 2018 · bioRxiv
  2. Variants of Unknown Significance in Maturity-Onset Diabetes of the Young: High Rate of Conundrum Resolution via Variants of Unknown Significance Reanalysis
    Guido Alarcon, Glenn A. Maston, Carol A. Hoffman, Jennifer Ellen Posey, MARIA JOSE REDONDO, Mustafa Tosur · 2024 · Hormone Research in Paediatrics
  3. AllelePred: A Simple Allele Frequencies Ensemble Predictor for Different Single Nucleotide Variants
    Turki M. Sobahy, Olaa Motwalli, Meshari Alazmi · 2022 · IEEE Transactions on Computational Biology and Bioinformatics
  4. Role of pharmacogenomics for prediction of personalized medicines
    Musaddique Hussain, Muhammad Qasim Barkat, Mobeen Fatima, Saira Shaukat, Taha Alqahtani, Ali Alqahtani, Wei Shi, Liu Mei, Ximei Wu · 2022 · Elsevier eBooks
  5. The role of SLC16A11 variations in diabetes mellitus
    Carlos Alberto Aguilar-Salinas, María Teresa Tusié Luna · 2023 · Current Opinion in Nephrology & Hypertension
  6. High Prevalence and Common Forms of Maturity-onset Diabetes of the Young in Greenland
    Anne Cathrine B. Thuesen, Marie Balslev Backe, Genís Garcia‐Erill, Mikkel Schubert, Kristian Hanghøj, Ida Moltke, Anders Albrechtsen, Niels Grarup, Anette P. Gjesing, Marit E. Jørgensen et al. · 2025 · Canadian Journal of Diabetes
  7. Diabetes
    Miriam S. Udler, José C. Florez · 2017 · Elsevier eBooks
  8. Validating and automating learning of cardiometabolic polygenic risk scores from direct-to-consumer genetic and phenotypic data: implications for scaling precision health research
    Arturo López Pineda, Manvi Vernekar, Sonia Moreno–Grau, Agustin Rojas‐Muñoz, Babak Moatamed, Ming Ta Michael Lee, Marco A. Nava-Aguilar, Gilberto Gonzalez-Arroyo, Kensuke Numakura, Yuta Matsuda et al. · 2022 · Human Genomics
  9. Genetics of Type 2 Diabetes
    Struan F.A. Grant · 2023 · Springer eBooks
  10. Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model
    Yoshiro Nagao · 2024 · Journal of Human Genetics
  11. HASTER is a transcriptional stabilizer of HNF1A
    Anthony Beucher, I. Miguel-Escalada, D. Balboa, Matías G. De Vas, M. Maestro, J. García-Hurtado, Aina Bernal, Roser Gonzalez-Franco, P. Vargiu, H. Heyn et al. · 2021 · bioRxiv
  12. TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins
    Xianghua Li, Ben Lehner · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Genetic Determinants of Type 2 Diabetes
    Miguel Cruz, Adán Valladares Salgado, Eugenia Flores‐Alfaro, José de Jesús Peralta Romero, Joel Rodríguez‐Saldaña · 2023 · Springer eBooks
  14. The hepatocyte nuclear factor 1 homeobox A (HNF1A) gene polymorphism and AFP serum levels in Egyptian HCC patients
    Hanan Mosaad Bedair, Ibrahim El Tantawy El Sayed, Olfat Mohamed Hendy, Mohmed Abdel-Samiee, Islam Abd El Hamid El Sayad, Sally S. Mandour · 2024 · Egyptian Liver Journal
  15. Delineation of New Disorders and Phenotypic Expansion of Known Disorders Through Whole Exome Sequencing
    Joseph A. Picoraro, Wendy K. Chung · 2015 · Current Genetic Medicine Reports
  16. Favorable outcomes in Hispanic recipients receiving simultaneous pancreas kidney transplantation
    Pooja Budhiraja, Kunam Sudhakar Reddy, Raymond L. Heilman, Caroline C. Jadlowiec, Hassan A. Khamash, Swetha Reddy, Nitin Katariya, Harini A. Chakkera · 2023 · Clinical Transplantation
  17. Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population
    Jaime Berumen-Campos, Lorena Orozco, Héctor Gallardo‐Rincón, Eligia Juárez-Torres, E. Barrera, Miguel Cruz, Rosa Elba Benuto, Espiridión Ramos-Martı́nez, Melissa Marin-Madina, Anabel Alvarado-Silva et al. · 2023 · Journal of Endocrinological Investigation
  18. Obesity and Metabolic Syndrome in Latin America
    Ana E. Espinosa De Ycaza, Stanley M. Chen Cardenas · 2023 · Springer eBooks
  19. Analysis of an adult diabetes mellitus caused by a rare mutation of the gene: A case report
    Wen-Xuan Li, Lili Xu, Chuan-Feng Liu, Bingzi Dong, Yun-yang Wang · 2024 · World Journal of Clinical Cases
  20. From genomics to precision medicine in type 2 diabetes
    Humberto Garcia‐Ortíz, Francisco Martin Barajas-Olmos, Cecilia Contreras-Cubas, Angélica Graciela Martínez-Hernández, Lorena Orozco · 2025 · Gaceta Médica de México
  21. Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes
    Amélie Bonnefond, Alan R. Shuldiner, Philippe Froguel · 2016 · Springer eBooks
  22. Rethinking the design process, rethinking the curriculum
    Michele Corsi, Pier Giuseppe Rossi · 2018 · EDUCATION SCIENCES AND SOCIETY
  23. Network medicine-travelling with the insulin receptor: Encounter of the second type
    Martial Boutchueng-Djidjou, Robert L. Faure · 2019 · EClinicalMedicine
  24. Estratificación del riesgo de pie diabético en adultos con diabetes mellitus
    Jesús Melchor Santos-Flores, Izamara Santos Flores, Milton Carlos Guevara Valtier, Juana Mercedes Gutiérrez-Valverde, María Diana Ruvalcaba-Rodríguez · 2019 · SANUS
  25. Leveraging fine-scale population structures for precision healthcare
    Masahiro Kanai · 2023 · Nature Medicine
  26. Applying Machine Learning on UK Biobank biomarker data empowers case-control discovery yield
    M. Garg, M. Karpinski, Dorota Matelska, Lawrence Middleton, J. Mitchell, A. O'Neill, Quan-Li Wang, Andrew R. Harper, R. Dhindsa, S. Petrovski et al. · 2023 · medRxiv
  27. Maturity Onset Diabetes of the Young (MODY) is not always monogenic: candidate genes involved in a Latino Population
    Alberto Moscona-Nissan, Daniel Marrero–Rodríguez, Sergio Andonegui-Elguera, Eduardo Salif Luna-Ávila, Florencia Martínez-Mendoza, Sandra Vela-Patiño, Itzel Ramírez-Ramos, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Rocio A Chavez-Santoscoy et al. · 2024 · medRxiv
  28. The Hunt for Low-Frequency Alleles Predisposing to Type 2 Diabetes and Related Cardiovascular Risk Factors
    Lorena Boquete Vilarino, Timothy M. Frayling · 2015 · Current Cardiovascular Risk Reports
  29. Controlling the Metabolic Roller Coaster in Diabetes
    Anne Rentoumis Cappola, Edward H. Livingston · 2014 · JAMA
  30. Fine-Mapping of Type 2 Diabetes Loci
    Laura J. Scott, Karen L. Mohlke · 2016 · Springer eBooks
  31. Familial Studies in Whole Exome and Genome Sequencing
    Janice L. Farlow · 2015 · IUScholarWorks (Indiana University)
  32. Searching for the Causal Variants of the Association Between Hypertriglyceridemia and the Genome-Wide Association Studies–Derived Signals?
    Carlos Alberto Aguilar-Salinas, Magdalena del Rocío Sevilla-González, Marı́a Teresa Tusié-Luna · 2017 · Circulation Cardiovascular Genetics
  33. Genetics of Diabetes and Diabetic Complications
    Rashmi B. Prasad, Emma Ahlqvist, Leif Groop · 2018 · Endocrinology
  34. Genetic Determinants of Type 2 Diabetes
    Miguel Cruz, Adán Valladares‐Salgado, Eugenia Flores‐Alfaro, José de Jesús Peralta Romero · 2019 · Springer eBooks
  35. Hepatocyte Nuclear Factor -1α stimulates cervical cancer cells to migrate and invade through regulating pyruvate kinase L/R
    Xiao-Ling Tao, Wei-chang Yu, Dejun Chen, Liming Wang, Lu Liu, Qi Xing · 2021 · Investigación Clínica
  36. The Heredity Matrix: Genetics and the Understanding ofMestizaje, Health, and Belonging in Mexico
    Carlos López-Beltrán, Abigail Nieves Delgado, Sandra P. González‐Santos, Vivette García Deister · 2022 · Science as Culture
  37. Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
    Jeffrey W. Kleinberger, Kevin M. Brown, Kristi D. Silver, Alan R. Shuldiner · 2017 · Springer eBooks
  38. Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
    Jeffrey W. Kleinberger, Kevin M. Brown, Kristi D. Silver, Alan R. Shuldiner · 2017 · Springer eBooks
  39. Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis
    Jeffrey W. Kleinberger, Alan R. Shuldiner, Kristi D. Silver · 2016 · Springer eBooks
  40. The TH01 microsatellite and INS VNTR are strongly associated with type 2 diabetes and fasting insulin secretion
    Jaime Berumen-Campos, Lorena Orozco, Héctor Gallardo‐Rincón, Eligia Juárez-Torres, Elizabeth Barrera, Miguel Cruz, Rosa Elba Benuto, Espiridión Ramos-Martı́nez, Melissa Marin-Madina, Anabel Alvarado-Silva et al. · 2022 · medRxiv
  41. Sex-specific genetic loci linked to early and late onset type 2 diabetes
    Jaime Berumen-Campos, Lorena Orozco, Héctor Gallardo‐Rincón, Rosa Elba Benuto, Espiridión Ramos-Martı́nez, Fernando Rivas, Humberto Garcia‐Ortíz, Melissa Marin-Madina, Elizabeth Barrera, Eligia Juárez-Torres et al. · 2022 · medRxiv
  42. Genetics of Type 2 Diabetes
    Struan F.A. Grant · 2023 · Springer eBooks
  43. The Genetics of Diabetes
    Rashmi B. Prasad · 2024 · Wiley eBooks
  44. Comorbid Conditions of Pediatric Obesity
    Manuel Moya Benavent · 2023 · Springer eBooks
  45. Differences in metabolic biomarkers in people with schizophrenia who are of Mexican descent compared to non-Hispanic whites
    Paulyn Kwak, Cynthia Ibarra, Alexa Hernandez, Jessica Carrasco, Dorothy D. Sears, Dilip V. Jeste, María J. Marquine, Ellen Lee · 2024 · Psychiatry Research
  46. Additional file 1 of Identification and validation of core genes for type 2 diabetes mellitus by integrated analysis of single-cell and bulk RNA-sequencing
    Tingting Yang, Chaoying Yan, Yang, Lan, Jialu Tan, Shiqiu Jiang, Juan Hu, Wei Gao, Qiang Wang, Yansong Li · 2023 · Figshare
  47. Genetic insights into fetal kidney development: Variants in HNF1A and PKHD1 genes
    Mayssa Abdelwahed, Valérie Benoît, B. Maalej, Pascale Hilbert, Laurence Michel‐Calemard, Hassen Kamoun, Leila Keskes, Neïla Belguith · 2024 · Gene
  48. Hepatocyte nuclear factor 1 alpha variants as risk factor for hepatocellular carcinoma development with and without diabetes mellitus
    Isis Samy Bedira, Ibrahim El Tantawy El Sayed, Olfat Mohamed Hendy, Mohamed Abdel‐Samiee, Amany Mohamed Rashad, Ahmed B. Zaid · 2024 · Gene Reports
  49. Diabètes monogéniques et oligogéniques : mieux les reconnaître pour une médecine de précision
    Amélie Bonnefond · 2025 · Médecine des Maladies Métaboliques
  50. From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes
    Romy Kursawe, Khushdeep Bandesh, Sai Nivedita Krishnan, Kevin S. Liu, Redwan M. Bhuiyan, Michael L. Stitzel · 2025 · Annual Review of Genetics
  51. Additional file 2 of Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia
    Cruz-Bautista, Ivette, Alicia Huerta‐Chagoya, Hortensia Moreno-Macías, Rosario Rodríguez-Guillén, Ordóñez-Sánchez, María Luisa, Yayoi Segura-Kato, Mehta, Roopa, Almeda-Valdés, Paloma, Lizeth Gómez-Munguía, Ximena Ruiz-De Chávez et al. · 2021 · Figshare
  52. Additional file 2 of Validating and automating learning of cardiometabolic polygenic risk scores from direct-to-consumer genetic and phenotypic data: implications for scaling precision health research
    Arturo Lopez-Pineda, Manvi Vernekar, Sonia Moreno–Grau, Agustin Rojas‐Muñoz, Babak Moatamed, Lee, Ming Ta Michael, Marco A. Nava-Aguilar, Gilberto Gonzalez-Arroyo, Kensuke Numakura, Yuta Matsuda et al. · 2022 · Figshare
  53. Additional file 1 of Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia
    Cruz-Bautista, Ivette, Alicia Huerta‐Chagoya, Hortensia Moreno-Macías, Rosario Rodríguez-Guillén, Ordóñez-Sánchez, María Luisa, Yayoi Segura-Kato, Mehta, Roopa, Almeda-Valdés, Paloma, Lizeth Gómez-Munguía, Ximena Ruiz-De Chávez et al. · 2021 · Figshare
  54. Additional file 4 of Validating and automating learning of cardiometabolic polygenic risk scores from direct-to-consumer genetic and phenotypic data: implications for scaling precision health research
    Arturo Lopez-Pineda, Manvi Vernekar, Sonia Moreno–Grau, Agustin Rojas‐Muñoz, Babak Moatamed, Lee, Ming Ta Michael, Marco A. Nava-Aguilar, Gilberto Gonzalez-Arroyo, Kensuke Numakura, Yuta Matsuda et al. · 2022 · Figshare
  55. Additional file 1 of Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
    Berumen, Jaime, Lorena Orozco, Gallardo-Rincón, Héctor, Rivas, Fernando, Elizabeth Barrera, Rosa Elba Benuto, Humberto Garcia‐Ortíz, Melissa Marin-Madina, Eligia Juárez-Torres, Anabel Alvarado-Silva et al. · 2024 · Figshare
  56. Additional file 6 of Validating and automating learning of cardiometabolic polygenic risk scores from direct-to-consumer genetic and phenotypic data: implications for scaling precision health research
    Arturo Lopez-Pineda, Manvi Vernekar, Sonia Moreno–Grau, Agustin Rojas‐Muñoz, Babak Moatamed, Lee, Ming Ta Michael, Marco A. Nava-Aguilar, Gilberto Gonzalez-Arroyo, Kensuke Numakura, Yuta Matsuda et al. · 2022 · Figshare
  57. Association study uncovers obesity-linked variants in mobile elements as potential regulators of gene expression
    Eira Huerta-Ávila, Angélica Graciela Martínez-Hernández, Francisco Martin Barajas-Olmos, Tomás López-Escobar, Diego Ramirez-Martínez, Cecilia Contreras-Cubas, María Elena González-Villalpando, José Rafael Villafán-Bernal, Federico Centeno-Cruz, José Antonio Quiroz-Pineda et al. · 2026 · iScience
  58. Étude post-GWAS des gènes de susceptibilité au diabète de type 2 : rôle phare dans la fonction de la cellule β pancréatique
    Fatou Kiné Ndiaye · 2017 · theses.fr (ABES)
  59. Integrating immunogenetics in T2DM research and practices
    Binty, Unnati Shukla, Manisha Singh, R. Rachana, Shalini Mani · 2026 · Elsevier eBooks
  60. Type 2 diabetes genetics in 125,000 admixed adults from Mexico City
    Jason Torres, Jaime Berumen-Campos, Diego J. Aguilar-Ramirez, Eirini Trichia, Francisco Martin Barajas-Olmos, Humberto Garcia‐Ortíz, Sam Morris, Michael Turner, Elizabeth Barrera, Tianshu Liu et al. · 2026 · medRxiv
  61. Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes
    Alberto Moscona-Nissan, Daniel Marrero–Rodríguez, Sergio Andonegui-Elguera, Eduardo Salif Luna-Ávila, Florencia Martínez-Mendoza, Sandra Vela-Patiño, Itzel Ramírez-Ramos, Silvia Hinojosa‐Álvarez, Jesús Hernández-Pérez, Rocío Alejandra Chávez-Santoscoy et al. · 2026 · Frontiers in Endocrinology
  62. Future perspectives: personalized medicine and senescence modulation in cardiovascular health
    Ishtiyaq Nissar, Jasreen Uppal, Mahak Gayaz, Apporva Chawla, Roohi Mohi-ud-din, Md. Sadique Hussain, Reyaz Hassan Mir, Anas Ahmad · 2026 · Elsevier eBooks