The DOI matches its Crossref record; 107 of the 116 references it cites were found in a registry or an index.
Evaluation and Management of Penicillin Allergy: A Review
Abstract
IMPORTANCE: β-Lactam antibiotics are among the safest and most effective antibiotics. Many patients report allergies to these drugs that limit their use, resulting in the use of broad-spectrum antibiotics that increase the risk for antimicrobial resistance and adverse events. OBSERVATIONS: Approximately 10% of the US population has reported allergies to the β-lactam agent penicillin, with higher rates reported by older and hospitalized patients. Although many patients report that they are allergic to penicillin, clinically significant IgE-mediated or T lymphocyte-mediated penicillin hypersensitivity is uncommon (<5%). Currently, the rate of IgE-mediated penicillin allergies is decreasing, potentially due to a decreased use of parenteral penicillins, and because severe anaphylactic reactions to oral amoxicillin are rare. IgE-mediated penicillin allergy wanes over time, with 80% of patients becoming tolerant after a decade. Cross-reactivity between penicillin and cephalosporin drugs occurs in about 2% of cases, less than the 8% reported previously. Some patients have a medical history that suggests they are at a low risk for developing an allergic reaction to penicillin. Low-risk histories include patients having isolated nonallergic symptoms, such as gastrointestinal symptoms, or patients solely with a family history of a penicillin allergy, symptoms of pruritus without rash, or remote (>10 years) unknown reactions without features suggestive of an IgE-mediated reaction. A moderate-risk history includes urticaria or other pruritic rashes and reactions with features of IgE-mediated reactions. A high-risk history includes patients who have had anaphylaxis, positive penicillin skin testing, recurrent penicillin reactions, or hypersensitivities to multiple β-lactam antibiotics. The goals of antimicrobial stewardship are undermined when reported allergy to penicillin leads to the use of broad-spectrum antibiotics that increase the risk for antimicrobial resistance, including increased risk of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. Broad-spectrum antimicrobial agents also increase the risk of developing Clostridium difficile (also known as Clostridioides difficile) infection. Direct amoxicillin challenge is appropriate for patients with low-risk allergy histories. Moderate-risk patients can be evaluated with penicillin skin testing, which carries a negative predictive value that exceeds 95% and approaches 100% when combined with amoxicillin challenge. Clinicians performing penicillin allergy evaluation need to identify what methods are supported by their available resources. CONCLUSIONS AND RELEVANCE: Many patients report they are allergic to penicillin but few have clinically significant reactions. Evaluation of penicillin allergy before deciding not to use penicillin or other β-lactam antibiotics is an important tool for antimicrobial stewardship.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Penicillin skin testing with a major determinant analog (penicilloyl-polylysine) and minor determinants (benzylpenicilloate, benzylpenilloate, or benzylpenicillin isomers of penicillin) are used for skin test evaluation for IgE-dependent penicillin allergy and can reliably identify persons at high risk for IgE-mediated reactions to penicillin (658,660,676).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [658]
In the citing paper
“Approximately 80% of patients with a true IgE-mediated allergic reaction to penicillin have lost the sensitivity after 10 years (658).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [658]
In the citing paper
“Prevalence of reported allergy to penicillin is approximately 10% among the U.S. population and higher among hospital inpatients and residents in health care–related facilities (655–658).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [658]
In the citing paper
“Allergic reactions with third-generation cephalosporins (e.g., ceftriaxone) are uncommon among persons with a history of penicillin allergy (620,631,658,896).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [658]
Citations
Cites
Berríos-Torres, S. I., Umscheid, C. A., Bratzler, D. W., Leas, B., Stone, E. C., Kelz, R. R., Reinke, C. E., Morgan, S., Solomkin, J. S., Mazuski, J. E., et al. (2017) · JAMA Surgery · doi:10.1001/jamasurg.2017.0904 · Cited by 3,569
Freifeld, A. G., Bow, E. J., Sepkowitz, K. A., Boeckh, M. J., Ito, J. I., Mullen, C. A., Raad, I. I., Rolston, K. V., Young, J.-A. H., & Wingard, J. R. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir073 · Cited by 3,463
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Tleyjeh, I. M., Rybak, M. J., Barsic, B., Lockhart, P. B., Gewitz, M. H., Levison, M. E., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000296 · Cited by 3,232 · cited 1×
“Antimicrobial Prophylaxis Antimicrobial prophylaxis includesdental prophylaxis toprevent infective endocarditis in select high-risk patients.(29,30) Administration of perioperative antibiotics reduces the risk of surgical site infections (SSIs).”
BackgroundBarlam, T. F., Cosgrove, S. E., Abbo, L. M., MacDougall, C., Schuetz, A. N., Septimus, E. J., Srinivasan, A., Dellit, T. H., Falck-Ytter, Y. T., Fishman, N. O., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw118 · Cited by 3,214
Sexually transmitted diseases treatment guidelines (2015)
Workowski, K., & BOLAN, G. A. (2015) · The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy · doi:10.18370/2309-4117.2015.24.51-56 · Cited by 2,684
Clinical practice guidelines for antimicrobial prophylaxis in surgery
Bratzler, D. W., Dellinger, E. P., Olsen, K. M., Perl, T. M., Auwaerter, P. G., Bolon, M. K., Fish, D. N., Napolitano, L. M., Sawyer, R. G., Slain, D., et al. (2013) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp120568 · Cited by 2,600
Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011
Fleming-Dutra, K. E., Hersh, A. L., Shapiro, D. J., Bartoces, M., Enns, E. A., File, T. M., Finkelstein, J. A., Gerber, J. S., Hyun, D. Y., Linder, J. A., et al. (2016) · JAMA · doi:10.1001/jama.2016.4151 · Cited by 1,740
Macy, E., & Contreras, R. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.021 · Cited by 829
US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014
Shehab, N., Lovegrove, M. C., Geller, A. I., Rose, K. O., Weidle, N. J., & Budnitz, D. S. (2016) · JAMA · doi:10.1001/jama.2016.16201 · Cited by 664
Marston, H. D., Dixon, D. M., Knisely, J. M., Palmore, T. N., & Fauci, A. S. (2016) · JAMA · doi:10.1001/jama.2016.11764 · Cited by 653
Cited by
Sorted by citations
Items 601–700 of 831
Update on Prenatal Laboratory Screening: Joint Commission Required Elements
Tepper, J. L., & Puopolo, K. M. (2019) · NeoReviews · doi:10.1542/neo.20-10-e584 · Cited by 1
Penicillin allergy labeling on medical alert jewelry
Foreman, C., Le, T.-T. A., Inglis, J. M., & Smith, W. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.03.002 · Cited by 1
Antimicrobial Stewardship for Transplant Candidates and Recipients
Liu, C., & Stohs, E. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-01751-4_6-1 · Cited by 1
Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders
Lalošević, M. S., Lalošević, J., Stjepanović, M., Stojanović, M., & Stojković, M. (2020) · Current Drug Metabolism · doi:10.2174/1389200221999201116143109 · Cited by 1
Der Antibiotic-Stewardship-Werkzeugkasten
Schulz-Stübner, S. (2020) · Springer eBooks · doi:10.1007/978-3-662-60558-5_5 · Cited by 1
Weniger ist mehr … in der Infektiologie
Fathi, A., Hennigs, A., & Addo, M. M. (2021) · Der Internist · doi:10.1007/s00108-021-00967-5 · Cited by 1
Taking a Rational Approach to a Reported Antibiotic Allergy
Berghuis, D., Lambregts, M. M. C., & de Boer, M. G. J. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002775 · Cited by 1
Evaluation of Patients With a History of Penicillin Allergy
Faitelson, Y., & Beigelman, A. (2019) · JAMA · doi:10.1001/jama.2019.4534 · Cited by 1
The Importance of Penicillin Allergy Evaluation in Pregnant Women
Iammatteo, M., & Solensky, R. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.12.012 · Cited by 1
Invited commentary: Promoting cephalosporin use among patients with penicillin allergy
Alexander, K. M. (2022) · Surgery · doi:10.1016/j.surg.2022.05.009 · Cited by 1
Olans, R. N., & Olans, R. D. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad478 · Cited by 1
Anaphylactic Shock in Pregnancy
Burwick, R. M. (2024) · Wiley eBooks · doi:10.1002/9781119820260.ch40 · Cited by 1
Antiquated Tools to Fight an Ancient Foe
Barbee, L. A., & Bachmann, L. H. (2025) · New England Journal of Medicine · doi:10.1056/nejme2508410 · Cited by 1
Olans, R. N., Witt, D. J., Marfatia, R., & Olans, R. D. (2025) · Antimicrobial Stewardship & Healthcare Epidemiology · doi:10.1017/ash.2025.10128 · Cited by 1
Tingsong, L. A. I., & Changqiang, L. I. (2026) · Acta Dermato Venereologica · doi:10.2340/actadv.v106.adv-2026-0848 · Cited by 1
Dinsmoor, M. J. (2005) · doi:10.1002/9781444312904.ch50
Vermeintliche Penicillin-Allergie ist meist gar keine
Leiner, P. (2019) · CME · doi:10.1007/s11298-019-7035-8
Evaluate Penicillin Allergy Before Deciding Against Penicillin Use
Rosenberg, K. E. (2019) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000554554.31522.ee
Carved in Stone with Consequences: Antibiotic Allergy Labels in Transplant Patients
Shenoy, E. S., & Ramsey, A. C. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz1028
Comment je conduis la consultation d’un patient qui se dit allergique ?
Malinovsky, J., Tacquard, C. A., & Mertès, P. (2019) · Le Praticien en Anesthésie Réanimation · doi:10.1016/j.pratan.2019.10.008
90 Prozent der „Penicillin-Allergiker“ sind gar keine!
Oberhofer, E. (2020) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-020-0086-7
Les réactions d’hypersensibilité aux médicaments anti-infectieux
Ponvert, C. (2020) · Revue française d'allergologie · doi:10.1016/j.reval.2020.01.002
Valeur prédictive négative des tests cutanés aux betalactamines solubles commerciales
Giamarchi, D., Guilleminault, L., & Didier, A. P. (2020) · Revue française d'allergologie · doi:10.1016/j.reval.2020.02.123
Lam, P. W. (2020) · TSpace (University of Toronto)
Domachowske, J. B., & Suryadevara, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-50873-9_58
Diagnosis and Treatment of Anaphylaxis Today
Kozu, Y. (2020) · Journal of Nihon University Medical Association · doi:10.4264/numa.79.2_65
Penicillin-Allergie – tödliche „Fake News“ in der Krankenakte?
Schulz-Stübner, S. (2020) · Intensivmedizin up2date · doi:10.1055/a-1157-5322
Leading the way in penicillin allergy evaluation
Redmond, M. T. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.09.009
Jones, B. M., & Bland, C. M. (2020) · JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY · doi:10.1002/jac5.1327
Antibiotic Allergy Labelling- may it cause Unnecessary Altered Antibiotic Treatment
Gerdås, S. (2020) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Self-reported allergy to parenterally administered penicillin
Ljubisavljević, M., & Živanović, S. (2020) · ABC - časopis urgentne medicine · doi:10.5937/abc2003043l
Hypersensibilités et allergies médicamenteuses
Pouessel, G., & Brouard, J. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-76475-2.00011-7
Surgical Site Infections (SSI) – Prophylaxis and Management
Merced, P. A. D., Nadler, E. P., & Hamdy, R. F. (2021) · Springer eBooks · doi:10.1007/978-3-030-72551-8_7
Antibiotic Therapy for Respiratory Infection
Jones, I. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00246-8
Spotlight in Plastic Surgery: July 2019
Phillips, B. T., Aliotta, R. E., Broyles, J. M., Firriolo, J. M., Goldman, J. J., Kantar, R. S., Kinuthia, K. M., Steve, A. K., Weinstein, A. L., & Gosain, A. K. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000005786
Standardizing Accurate Penicillin Drug Allergy Diagnosis via a Smartphone App
Rider, N. L. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.08.015
Bircher, A. J., Jamiolkowski, D., Steveling, E. H., Hofmeier, K. S., & Mateluna, C. M. (2022) · Aktuelle Dermatologie · doi:10.1055/a-1539-2221
Fasting Has Limited Impacts on the Result of Penicillin Allergy Skin Test: An Observation Study
XIONG, Z., Wenrong, W. U., Huang, X., & Xiaomin, N. I. (2021) · Medical Research · doi:10.6913/mrhk.202109_3(3).0002
Gitu, A. C., & Skiff, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-54441-6_168
Valeur prédictive négative des tests cutanés aux bétalactamines solubles commerciales
Giamarchi, D., Guilleminault, L., & Didier, A. P. (2021) · Revue française d'allergologie · doi:10.1016/j.reval.2021.03.105
MacGregor, C. A., & Dinsmoor, M. J. (2020) · doi:10.1002/9781119635307.ch35
Delayed Sepsis Management Due to Ambiguous Allergy
(2020) · AORN Journal · doi:10.1002/aorn.13253
Antimicrobial Stewardship for Transplant Candidates and Recipients
Liu, C., & Stohs, E. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-25869-6_6
Der Antibiotic-Stewardship-Werkzeugkasten
Schulz-Stübner, S. (2020) · Springer eBooks · doi:10.1007/978-3-662-60560-8_5
Gitu, A. C., & Skiff, A. (2020) · Springer eBooks · doi:10.1007/978-1-4939-0779-3_168-1
Miceli, L. M., Chang, O. H., Zhang, S., Yao, M., & Propst, K. A. (2022) · Journal of Gynecologic Surgery · doi:10.1089/gyn.2021.0134
Kılıç, P., Karabudak, S., Coşar, B., Savran, B. N., & Yalcin, M. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4176687
Wrynn, A. F. (2022) · The Nurse Practitioner · doi:10.1097/01.npr.0000855312.11145.78
Surgical antibiotic prophylaxis: current issues of beta-lactams use
Zyryanov, S. K., & Butranova, O. I. (2022) · Hirurg (Surgeon) · doi:10.33920/med-15-2204-07
Penicillin-Allergie – tödliche „Fake News“ in der Krankenakte?
Schulz-Stübner, S. (2022) · Zahnmedizin up2date · doi:10.1055/a-1884-2993
Advances in immunoglobulin E mediated antibiotic allergy
Rukasin, C. R. F., Phillips, E. J., & Stone, C. A. (2022) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001171
Primary care physicians present a gap of knowledge regarding the management of penicillin allergy
Faitelson, Y., & Beigelman, A. (2022) · Pediatric Allergy and Immunology · doi:10.1111/pai.13857
Anafilaxia a beta-lactâmicos – Quando a tolerância não exclui alergia
Palhinha, A., Lobato, M., Romeira, A., & Pinto, P. (2022) · Revista Portuguesa de Imunoalergologia · doi:10.32932/rpia.2022.09.089
Die Flut der Fälle bei Arzneimittelallergien
Buhl, T., & Forkel, S. (2022) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14939_g
Lee, M. J., & Chambliss, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95061-9.00015-1
Antimicrobials in the Management of Sepsis
Jacobi, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88271-2.00032-8
Allergy identification for neurosurgical patients: updates for management
Liu, A., Villarreal, X. P., & Lucke-Wold, B. P. (2023) · Clinical Research Communications · doi:10.53388/crc2023008
Group B streptococcus in obstetrics: unsolved problems
Radzinsky, V. E., Doronina, O. K., Olenev, A. S., & Stetsyuk, O. V. (2023) · RUDN Journal of Medicine · doi:10.22363/2313-0245-2023-27-1-9-16
The evaluation of penicillin allergy in dialysis patients
Sirkeoja, S., Honkanen, M., Huttunen, R., Mäkelä, S., & Syrjänen, J. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad072
Hypersensitivity to antibiotics: principles of diagnosis
Vykhrystenko, L., Vykhrystenko, K., & Rybchenko, N. (2023) · Immunopathology Allergology Infectology · doi:10.14427/jipai.2023.1.11
Hamon, A., Bastides, F., & Lefort, A. (2023) · EMC - AKOS - Trattato di Medicina · doi:10.1016/s1634-7358(23)47810-2
Bland, C. M., Heil, E. L., Asbell, A., Smith, S. E., & Jones, B. M. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.06.019
Wittmer, R., Vincent-Boulay, O., & Lacombe‐Barrios, J. (2023) · Canadian Medical Association Journal · doi:10.1503/cmaj.221266-f
Drug allergy testing in the Department of Dermatology and Allergology, University of Szeged
Mihályi, L., Belső, N., Ónodi‐Nagy, K., Mezős, A., Pénzes, A., & Bata‐Csörgõ, Z. (2023) · Bőrgyógyászati és Venerológiai Szemle · doi:10.7188/bvsz.2023.99.2.10
Nürnberg, H., Khatamzas, E., Denkinger, C. M., Krause, T., Oetken, L., Rauer, S., Rapp, A., Hoppe‐Tichy, T., & Morath, B. (2023) · medRxiv · doi:10.1101/2023.07.17.23291645
Luque, J. C., Rei, M. J., Capoulas, M., dos Santos, C. S. S., & Raimundo, P. O. (2023) · Farmacia Hospitalaria · doi:10.1016/j.farma.2023.07.017
Antibiotikaallergien – gezieltes Vorgehen bei vermeintlicher β‑Laktam-Allergie
Hornuß, D., & Rieg, S. (2023) · Die Urologie · doi:10.1007/s00120-023-02191-5
Deimel, L. P., Moynié, L., Sun, G., Lewis, V. G., Turner, A., Buchanan, C. J., Burnap, S. A., Kobras, C. M., Stracy, M., Struwe, W. B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.02.565155
Penicillin Allergy is Not Forever
Plager, J. H., & Phillips, E. J. (2023) · Springer eBooks · doi:10.1007/978-981-99-4440-8_123
Utility of beta-lactam allergy assessment in patients receiving vancomycin for surgical prophylaxis
Tucker, K. J., Ham, Y., Holmer, H. K., McCracken, C. M., Sukerman, E. S., Lewis, J. S., & McGregor, J. C. (2023) · Surgery in Practice and Science · doi:10.1016/j.sipas.2023.100232
Orzechowski, D., Bryła, A., & Chmal-Jagiełło, K. (2023) · Farmacja Polska · doi:10.32383/farmpol/177268
Baghdady, N., & Alothmany, H. N. (2023) · Cureus · doi:10.7759/cureus.51322
Facteurs de risque infectieux liés à l'hôte en chirurgie prothétique
Marmor, S., & Kerroumi, Y. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77987-9.00029-8
Lin, Y., Huang, J., Yue, J., Cheng, L., Ma, Y., Pan, W., Ju, J., Wei, H., & Feng, B. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1746257
Burgener-Gasser, A.-V., Fasel, J., Halbeisen, D., Hartmann, K., Weisser, M., Kaufmann, C., & Tschudin‐Sutter, S. (2024) · Antimicrobial Stewardship & Healthcare Epidemiology · doi:10.1017/ash.2024.5
Drug allergy versus adverse reactions
Teoh, L., Moses, G., & McCullough, M. J. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009057950.004
Maler, V., Goetz, V., Tardieu, M., Khalil, A. E., Alili, J., Meunier, P., Maillot, F., & Labarthe, F. (2023) · Figshare · doi:10.6084/m9.figshare.23435182
Dimitroglou, M., Moriki, D., Sardeli, O., Kartsiouni, E., Koumpagioti, D., Galani, A., Papaevangelou, V., & Douros, K. (2024) · Allergies · doi:10.3390/allergies4020005
Jeong, W., Saleh, S., Heap, S., Pham, V., Leung, L., & Krishnaswamy, S. (2024) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.13819
Breaking the stigma: Safe use of Cefazolin in perioperative patients with penicillin allergy label
Manlapaz, M. R., & Farag, E. S. (2024) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2024.111541
The Global Prevalence of Penicillin Allergy: A Systematic Review and Meta-AnalysisPreprint
Luintel, A., Healy, J., Blank, M. B., Luintel, A., Dryden, S., Das, A., Darzi, A. W., & Cooke, G. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4891731
Diagnostics and antibacterial therapy of streptococcus-associated tonsillitis
Dengina, A. V., Karpov, V. P., Батурин, В. А., & Badiryan, L. S. (2024) · Medical news of the North Caucasus · doi:10.14300/mnnc.2024.19028
Der Antibiotic-Stewardship-Werkzeugkasten
Schulz-Stübner, S. (2024) · Springer eBooks · doi:10.1007/978-3-662-68836-6_5
Adesanya, O. A., Bowler, N., Tafuri, S. M., Cruz-Bendezú, A., & Whalen, M. J. (2024) · Urologic Clinics of North America · doi:10.1016/j.ucl.2024.06.005
Nguyen, N.-T., & Pennello, G. A. (2024) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfae054
Empowering Pediatricians With Direct Penicillin Challenges: A Promising Delabeling Strategy
Park, K., & Schwartz, D. J. (2024) · Military Medicine · doi:10.1093/milmed/usae347
Choc anaphylactique en anesthésie pédiatrique
Michel, F. (2024) · Elsevier eBooks · doi:10.1016/b978-2-294-78062-2.00017-6
Getting to the Bottom of a Patient’s Penicillin Allergy Label
Johannesmeyer, H. J. (2024) · Journal of Infusion Nursing · doi:10.1097/nan.0000000000000584
Ruysscher, F. D., Dua, E., Lapeere, H., & Coppens, M. J. (2025) · Tijdschrift voor Geneeskunde · doi:10.47671/tvg.80.24.104
Új irányelvek az infektív endocarditis megelőzésében és ezek fogászati és szájsebészeti vonatkozásai
Major, Á., Simon, G., Zsoldos, M., Nagy, A. I., Hermann, P., Merkely, B. P., & Joób-Fancsaly, Á. (2025) · Orvosi Hetilap · doi:10.1556/650.2025.33219
Reducing Unnecessary Penicillin Allergy Labels in the Pediatric Surgical Population
Hefel, A., Wang, L. A., Bauer, M. E., Tong, S., & Tan, G. M. (2024) · Journal of Nursing Care Quality · doi:10.1097/ncq.0000000000000813
Bokun, T., Zelenika, M., & Kujundžić, M. (2024) · Clinical gastroenterology · doi:10.1007/978-3-031-69800-2_31
Lau, X. M. N., Zhu, X., Sidhu, D., Bay, J. W., Mo, Y., & Tambyah, P. A. (2025) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlaf035
Román, M., & Parker, M. W. (2025) · Journal of Hospital Medicine · doi:10.1002/jhm.70030
Antibiotic use and financial impact of a comprehensive beta-lactam allergy management program
Raja, K., Vyas, L., Morrison, S., Beggs, D., Patel, M., & Philips, M. (2025) · Antimicrobial Stewardship & Healthcare Epidemiology · doi:10.1017/ash.2025.36
Varón de 52 años con erupción cutánea durante un tratamiento farmacológico
Montúfar, D. M. T., & Pan, C. V. (2025) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2025.04.009
Hollenbeck, B. L., Erossy, M. P., & Miley, G. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-83959-7_62
Genier, S. A., Trivelli, G., & Mitter, V. R. (2025) · Swiss Medical Weekly · doi:10.57187/s.4297
Adolescence Is a Critical Time for Clinicians to Address Penicillin Allergy
Wang, L. A., & O’Leary, S. T. (2025) · Clinical Pediatrics · doi:10.1177/00099228251340353
Single-shot perioperative antibiotic prophylaxis in patients with a history of penicillin allergy
Rüggeberg, A., Lommel, K., Tiedt, N., & Nickel, E. A. (2025) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2025.0107
Metadata
- Authors
- Shenoy, E. S., Macy, E., Rowe, T., & Blumenthal, K. G.
- Affiliations
- Harvard University (US)
- Department of Allergy, Southern California Permanente Medical Group, San Diego Medical Center
- Northwestern University (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2019-01-15
- Volume
- 321
- Issue
- 2
- Pages
- 188
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2909667144
- Cited by
- 830
- References
- 116
- Citations by year
- 2026: 109 · 2025: 120 · 2024: 130 · 2023: 132 · 2022: 100 · 2021: 90 · 2020: 89 · 2019: 58
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- penicillin allergy, beta-lactam antibiotics, IgE-mediated hypersensitivity, penicillin skin testing, antimicrobial stewardship, broad-spectrum antibiotic use, antimicrobial resistance, Clostridium difficile infection, methicillin-resistant Staphylococcus aureus
- MeSH terms
- Amoxicillin, Anti-Bacterial Agents, Desensitization, Immunologic, Drug Hypersensitivity, Female, Humans, Immunoglobulin E, Immunologic Tests, Penicillins, Pregnancy, beta-Lactams, Patient Acuity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
