Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure–Guided Strategy vs an Empirical High PEEP-F io 2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial

Beitler, Jeremy R., Sarge, Todd, Banner-Goodspeed, Valerie M., Gong, Michelle N., Cook, Deborah, Novack, Victor, Loring, Stephen H., Talmor, Daniel +1 more·2019·JAMA

DOI 10.1001/jama.2019.0555

Cited by (469)

Items 401–469 of 469

Análise regulatória de ventiladores mecânicos aprovados sob condições extraordinárias: um estudo abrangente e desenvolvimento de guia para futuras emergências.
Cristina Quemelo Adami Fais · 2025
Positive end-expiratory pressure optimization with esophageal pressure during prone position in severe acute respiratory distress syndrome: a physiologic study
Laure Crognier, Arthur Villain-Amirat, Jean‐Marie Conil, Baptiste Compagnon, E. Chambon, Adam Tuijnman, Michaël Poette, Juliette Joseph, Stéphanie Ruiz, Vincent Minville et al. · 2025 · Heart & Lung
Underreporting of Acute Kidney Injury in Randomized Trials of ARDS with Mortality Endpoints: A Systematic Review
Rogério da Hora Passos, Bruno Zawadzki, Luis Claudio Santos Pinto, Rafael Hortencio Melo, Thais Dias Midega, Bruno de Arruda Bravim, Vagner Pires de Campos Junior, Arnaldo Alves da Silva, Prashant Nasa, Fernanda Oliveira Coelho · 2025 · Research Square
The Stiff Lung Cries Out for Negative Pressure Ventilation
Jan van Egmond · 2025 · Journal of Clinical Medical Research
Advance in Mechanical Ventilator Technology for Respiratory Failure in Cardiac Disorders
Berkan Basançelebi, Juan Martín Núñez Silveira, Kadir İdin · 2025 · Noninvasive ventilation. The essentials
Mise au point : que disent les dernières recommandations européennes sur le SDRA ?
Joris Pensier, Mathieu Capdevila, Clément Monet, Inès Lakbar, Yassir Aarab, Audrey Debrus, Soufian El Idrissi, Audrey DE JONG, Samir Jaber · 2025 · Anesthésie & Réanimation
Identifying optimal positive end-expiratory pressure by body mass index does not account for natural physiologic variability in pleural pressure
Skyler A. Lentz, Olivia Serigano, William G. Tharp · 2025 · Anaesthesia Critical Care & Pain Medicine
Additional file 7 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Muneyuki Takeuchi, Hideto Yasuda, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 2 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Hideto Yasuda, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 2 of Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
Laurent Papazian, Samir Jaber, Sami Hraiech, Baumstarck, Karine, Sophie Cayot-Constantin, Nadia Aïssaoui, Boris Jung, Marc Léone, Bertrand Souweine, Carole Schwebel et al. · 2021 · Figshare
Additional file 1 of Impact of the transpulmonary pressure on right ventricle impairment incidence during acute respiratory distress syndrome: a pilot study in adults and children
Meryl Vedrenne‐Cloquet, Matthieu Petit, Sonia Khirani, Cyril Charron, Diala Khraiche, Elena Panaioli, Habib, Mustafa, Sylvain Renolleau, Brigitte Fauroux, Antoine Vieillard‐Baron · 2024 · Figshare
Additional file 4 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Muneyuki Takeuchi, Hideto Yasuda, Ichikado, Kazuya, Tsushima Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 1 of Association of different positive end-expiratory pressure selection strategies with all-cause mortality in adult patients with acute respiratory distress syndrome
Manuel Tisminetzky, José Dianti, Bruno Leonel Ferreyro, Angriman, Federico, Lorenzo Del Sorbo, Sachin Sud, Daniel S. Talmor, Fan, Eddy, Niall D. Ferguson, Ary Serpa Neto et al. · 2021 · Figshare
Additional file 1 of Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
Laurent Papazian, Samir Jaber, Sami Hraiech, Baumstarck, Karine, Sophie Cayot-Constantin, Nadia Aïssaoui, Boris Jung, Marc Léone, Bertrand Souweine, Carole Schwebel et al. · 2021 · Figshare
Additional file 3 of Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
Laurent Papazian, Samir Jaber, Sami Hraiech, Baumstarck, Karine, Sophie Cayot-Constantin, Nadia Aïssaoui, Boris Jung, Marc Léone, Bertrand Souweine, Carole Schwebel et al. · 2021 · Figshare
Additional file 1 of Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review
Laurent Renard Triché, Emmanuel Futier, Manuela De Carvalho, Nathalie Piñol‐Domenech, Laëtitia Bodet-Contentin, Matthieu Jabaudon, Bruno Pereira · 2023 · Figshare
Additional file 1 of Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
Elias Baedorf Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Garcia, Ivan, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie Banner‐Goodspeed, Michael A. Matthay et al. · 2024 · Figshare
Additional file 3 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Muneyuki Takeuchi, Hideto Yasuda, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 6 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Muneyuki Takeuchi, Hideto Yasuda, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 1 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Hideto Yasuda, Ichikado, Kazuya, Tsushima Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 2 of Association of different positive end-expiratory pressure selection strategies with all-cause mortality in adult patients with acute respiratory distress syndrome
Manuel Tisminetzky, José Dianti, Bruno Leonel Ferreyro, Angriman, Federico, Lorenzo Del Sorbo, Sachin Sud, Daniel S. Talmor, Fan, Eddy, Niall D. Ferguson, Ary Serpa Neto et al. · 2021 · Figshare
Additional file 1 of Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials
Lorenzo Ball, Ary Serpa Neto, Valeria Trifiletti, Maura Mandelli, Iacopo Firpo, Robba, Chiara, Marcelo Gama de Abreu, Marcus Josephus Schultz, Patroniti, Nicolò, P R Rocco et al. · 2020 · Figshare
Additional file 1 of Bedside personalized methods based on electrical impedance tomography or respiratory mechanics to set PEEP in ARDS and recruitment-to-inflation ratio: a physiologic study
Bertrand Pavlovsky, Christophe Desprez, Jean-Christophe Richard, Nicolas Fage, Arnaud Lesimple, Dara Chean, Antonin Courtais, Tommaso Mauri, Alain Mercat, François Beloncle · 2024 · Figshare
Additional file 1 of Recruitment-to-inflation ratio reflects the impact of peep on dynamic lung strain in a highly recruitable model of ARDS
Francesco Murgolo, Grieco, Domenico L., Savino Spadaro, Nicola Bartolomeo, Rossella Di Mussi, Luigi Pisani, Marco Fiorentino, Crovace, Alberto Maria, Luca Lacitignola, Francesco Staffieri et al. · 2024 · Figshare
Additional file 1 of Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS: a phase II randomized controlled trial
Costa, Eduardo L. V., Glasiele Alcala, Mauro Roberto Tucci, Goligher, Ewan, Morais, Caio C., José Dianti, Miyuki A. P. Nakamura, Larissa B. Oliveira, Pereira, Sérgio M., Carlos Toufen et al. · 2024 · Figshare
Additional file 1 of Effects of prone positioning on lung mechanical power components in patients with acute respiratory distress syndrome: a physiologic study
Christoph Boesing, Joerg Krebs, Alice Marguerite Conrad, Matthias Otto, Beck, Grietje, Thiel, Manfred, P R Rocco, Thomas Luecke, Schaefer, Laura · 2024 · Figshare
Additional file 5 of ARDS Clinical Practice Guideline 2021
Sadatomo Tasaka, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Yasuda Hideto, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu et al. · 2022 · Figshare
Additional file 1 of Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study
Roberto Tonelli, Grasso, Salvatore, Cortegiani, Andrea, Lorenzo Ball, Ivana Castaniere, Luca Tabbì, Fantini, Riccardo, Dario Andrisani, Filippo Gozzi, Moretti, Antonio et al. · 2024 · Figshare
Additional file 1 of Physiological and clinical variables identify ARDS classes and therapeutic heterogeneity to glucocorticoids: a retrospective study
Liao, Qingbo, Pu, Yufan, Jin, Xiaoer, Zhiwei Zhuang, Xu, Xiaowen, Ren, Xiaoqiang, Gaoqing Liu, Ding, Qi · 2024 · Figshare
Treatment Response Phenotyping Informed by Patient Physiologic Characteristics Could Drive Precision Critical Care Through Augmented Intelligence
Andre L. Holder, G. Abgrall, Ran Xiao, Jacques Kpodonu, Shane Nanayakkara, Irene Dankwa‐Mullan, Ann Alexandra Zalucky, Xavier Monnet, Ewan C. Goligher · 2025 · CHEST Critical Care
S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge – Update 2025
Brunkhorst, Frank M., Adamzik, Michael, Axer, Hubertus, Bauer, Michael, Bode, Christian, Bone, Hans-Georg, Brenner, Thorsten, Bucher, Michael, David, Sascha, Dietrich, Maximilian et al. · 2025 · RWTH Publications (RWTH Aachen)
Regulatory analysis of mechanical ventilators approved under extraordinary conditions: a comprehensive study and guideline development for future emergencies.
Cristina Quemelo Adami Fais · 2025 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
The influence of transpulmonary pressure on pulmonary vascular resistance -a physiological study using echocardiography during CPAP
Simon Lindner, Burcu Link, Luisa Sophie Sophie Drotleff, Lena Doerflinger, Henning Johann Steffen, İbrahim Akın, D R Duerschmied, Simone Britsch · 2026 · Biomedical Physics & Engineering Express
Impact biologique, morphologique et clinique du maintien d'une ventilation pulmonaire lors de la circulation extracorporelle en chirurgie cardiaque : selon une approche « Open-Lung »
David Lagier · 2019
Imagerie fonctionnelle et quantitative des lésions pulmonaires induites par la ventilation mécanique sur poumons sains et agressés
Laurent Bitker · 2021
Apport de la tomographie par impédance électrique pour personnaliser la ventilation mécanique au cours du syndrome de détresse respiratoire aigu réfractaire traité par ECMO veino-veineuse
Guillaume Franchineau · 2021
Mécanique respiratoire au cours de l’insuffisance respiratoire aiguë : intérêt de la mesure de la pression œsophagienne et des nouveaux outils de monitorage
François Beloncle · 2021
Effects of Different Fractions of Inspired Oxygen on Oxygenation Function and Postoperative Pulmonary Complications in Elderly Patients Undergoing Laparoscopic Radical Cystectomy
亚萌卜 · 2026 · Advances in Clinical Medicine
Biomimetic lung simulator for regional intrapulmonary pressure measurement during mechanical ventilation
Keywan Sohrabi, Jasmin Spaar, T N Jung, Niklas Ostwald, Patrick Fischer, Oskar Seifert, Dominik Kraft, István Vadász · 2026 · Research Square
Scheduled Bronchoscopy with Nebulized Heparin and N-Acetylcysteine in Burn Patients with Inhalation Injury: A Randomized Trial
Thái Ngọc Minh Nguyễn, Như Lâm Nguyễn, Dinh Hung Tran · 2026 · European Burn Journal
Importance and frequency of using esophageal pressure monitoring during ventilatory support. A cross-sectional study
María Lucía Giménez, Emilio Steinberg, Luis Garegnani · 2026 · medRxiv
Precision PEEP Titration in Cardiac Surgery: Transitioning from Global Mechanics to EIT-Guided Regional Ventilation Management (Preprint)
Weiwei Wang, Xiaoyu Ma, Ziwei Zou, Dehui Fan · 2026
Technology-Enhanced Strategies to Optimize Positive End-Expiratory Pressure in Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis
Adam Jonathan Boulton, Adel Elfeky, Rachel A. Court, Amy Grove, Anna Wilson, Peter Auguste, Daniel Clayton, Daniel Gallacher, Ewan C. Goligher, Catherine MacLeod Hall et al. · 2026 · Critical Care Medicine
Central Venous Pressure Revisited: Physiology, Pitfalls, Misconceptions, and Modern Clinical Interpretation in Critical Care
Cesare Biuzzi, Elena Modica, Lucrezia Pondrelli, Alexander Raimondi, Margherita Cavenago, Daniele Marianello, Filippo Annoni, Fabio Silvio Taccone, Federico Franchi, Sabino Scolletta · 2026 · Journal of Clinical Medicine
Strategies to Manage Refractory Hypoxemia in the Intubated Patient
Margaret L. Davis, Robert J. Klemisch · 2026 · Emergency Medicine Clinics of North America
The Impact of Patient Positioning on the Compromised Respiratory System
B. Harris, Richard A. Oeckler, Francesca Collino, Sritika Thapa, D P Narenda, Gustavo A. Cortes-Puentes · 2026 · Respiratory Care
Hemodynamic Impacts of Mechanical Ventilation
Sheldon A. Magder, Christopher Lai · 2026 · Clinics in Chest Medicine
Transpulmonale Druckmessung während Beatmung auf Intensivstation
Christoph Laußer, Thomas Flohr · 2026 · Pneumologie
Positive end-expiratory pressure titration in acute respiratory distress syndrome–a practical bedside algorithm
Luís Melo, João João Mendes · 2026 · Frontiers in Medicine
Trajectories of oxygenation index and PEEP levels associated with 28-day mortality in sepsis-associated ARDS: a multicenter cohort study
Lina Zhao, Lei Zong, Wei Wei, Qian Cui, Yixin Xue, Xiaohui Wu, Yu Meng, Shuoyan Dong, Jie Liu, Ying Gao et al. · 2026 · International Journal of Infectious Diseases
Ventilatory management of patients with acute respiratory distress syndrome and optimization of lung mechanics
Cristina Mietto, Neil E. Rens, Andrea Restivo, Michele delle Vergini, Genevieve McCormack, Stefano Spina · 2026 · Best practice & research. Clinical anaesthesiology
Estimation of deflation parameters as a surrogate for transpulmonary pressure from regional pressure-flow-curves derived from electrical impedance tomography in a porcine model of the acute respiratory distress syndrome
Maike Henkel, Paul Frenkel, Fabian Müller‐Graf, Jonas Merz, Chiara Felicitas Schlögel, Susanne Reuter, Brigitte Vollmar, Amelie R. Zitzmann, Daniel Arnulf Reuter, Sven Pulletz et al. · 2026 · Physiological Measurement
Underreporting of acute kidney injury in randomized trials of acute respiratory distress syndrome with mortality endpoints: a systematic review
Rogério da Hora Passos, Bruno Zawadzki, Luís Cláudio Santos Pinto, Rafael Hortêncio Melo, Thais Dias Midega, Bruno de Arruda Bravim, Vagner Pires de Campos, Arnaldo Alves da Silva, Prashant Nasa, Fernanda Oliveira Coelho · 2026 · Critical Care Science
The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study
Xiao Tang, Ting Li, Hua Yang, Yalan Liu, Wen‐Rui Lyu, Yu Zhao, Hai-chao Li, Meng Li, Hu Li, Yu Jin et al. · 2026 · Critical Care Explorations
End-Expiratory Transpulmonary Pressure Close to 0 and Clinical Outcomes in Pediatric ARDS
Yukie Ito, Daniel Chang, Justin Christian Hotz, Meryl Vedrenne‐Cloquet, Muneyuki Takeuchi, Bhushan H. Katira, Anoopindar K. Bhalla, Christopher J. L. Newth, Robinder G. Khemani · 2026 · CHEST Critical Care
Ventilation du patient passif
Alexandre Demoule, Gaëtan Beduneau, Rémi Coudroy, Guillaume Carteaux, Jean‐Pierre Frat, Lise Piquilloud, François Beloncle, Antoine Roch, Benjamin Assouline, Laurent Bitker et al. · 2025 · Elsevier eBooks
Advances in Dynamic Assessment Techniques for Lung Injury in Acute Respiratory Distress Syndrome
丽娟高 · 2026 · Advances in Clinical Medicine
ARDS management beyond the guidelines: a practical physiology-based approach to individualized care
Nattapat Wongtirawit, Luca Salvatore Menga, Roberto Brito, Mattia Docci, Glauco M. Plens, Glasiele Alcala, Ben Cantan, Karen J. Bosma, Matthew Ko, Georgiana Roman-Sarita et al. · 2026 · Intensive Care Medicine
Electrical impedance tomography–guided individualized ventilation strategy in patients with trauma-related and postoperative acute respiratory distress syndrome
Minh Nguyễn Việt, Thuy Luu Quang, Dong Trinh Van, Thu Nguyen Dang, Huyên Nguyễn Thị · 2026 · PLoS ONE
Consenso colombiano de síndrome de dificultad respiratoria aguda 2026
Manuel Garay Fernández, Guillermo Ortiz-Ruiz, Carmelo Rafael Dueñas Castell, Mónica Vargas, Marco A. González A., Nestor David Caicedo Buitrago, Alexander Guezguan, Andrés Fabricio Caballero-Lozada, Alejandro Segura Ordóñez, Paula López-Garzón et al. · 2026 · Acta Colombiana de Cuidado Intensivo
Extracorporeal Membrane Oxygenation: The Guardian Angel for the Severely Hypoxic and Its Judicious Use
Apoorva Gupta, Sanjeev Mittal, Vikalp Khatri · 2026 · Indian Journal of ECMO
Intraoperative Mechanical Ventilation
Marina Roger, Miguel Linares Torras, Jordi Vallverdú, Carlos Ferrando Ortolà · 2026 · Springer eBooks
ARDS – Pathophysiologie, Diagnostik und moderne Therapiestrategien
Sebastian Mang, Saskia Danielsmeier, R.M. Muellenbach, Jonas Ajouri, Torben Millard Rixecker, Sean Selim Scholz, Onnen Moerer, Hermann Wrigge, Hendrik Bracht, Philipp M. Lepper · 2026 · DMW - Deutsche Medizinische Wochenschrift
Transpulmonary Driving Pressure, End-Expiratory Transpulmonary Pressure, and Mortality in Pediatric ARDS
Ekin Soydan, Ozlem Demirel, Kaan Aslan, Gülhan Atakul, Sevgi Topal, Mustafa Çolak, Özlem Saraç Sandal, Ferhat Sarı, Selçuk Sinan Çelik, Utku Karaarslan et al. · 2026 · Respiratory Care
Right ventricular-protective ventilation in acute respiratory distress syndrome: phenotypes, monitoring and ventilatory management
Chengchao Peng, Le Yang, Yongran Wu, You Shang, Xiaojing Zou · 2026 · European Respiratory Review
Setting Positive End-Expiratory Pressure in the Acute Respiratory Distress Syndrome
Sarina K. Sahetya, Arthur S. Slutsky, Roy G. Brower · 2026 · Critical Care Medicine
Association Between Cdyn‐Guided PEEP and Nursing Activities During PACU Recovery in Infants Undergoing One‐Lung Ventilation: A Retrospective Observational Cohort Study
Mingran Hao, Bin Zhang, Yuejiao Han, Changbin Zhao, Zhaoyuan Dong, Benqin Song · 2026 · Nursing Open
Mechanical ventilation before and during veno-venous extracorporeal membrane oxygenation
Marco Giani, Alessandro Vatta, Livia Foglia Manzillo, Carlo Riggio, Luigi Camporota, Emanuele Rezoagli · 2026 · Expert Review of Medical Devices
Development and technical characterization of a biomimetic thorax simulator for regional intrapulmonary pressure measurement
Keywan Sohrabi, Jasmin Spaar, Tibor Jung, Niklas Ostwald, Patrick Fischer, Oskar Seifert, Dominik Kraft, István Vadász · 2026 · Frontiers in Bioengineering and Biotechnology