Combination Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: Not Ready for Prime Time
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Various commercially available antimicrobial drugs exhibit prominent defects, including nonspecific targeting and low concentrations in the lesion, leading to low efficiency, high toxicity, various side effects and multidrug resistance.
“At present, various commercially available antimicrobial drugs exhibit some prominent defects, including nonspecific targeting and low concentrations in the lesion, which leads to low efficiency, high toxicity, various side effects15 and multidrug resistance.16,17”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [17]
Cites
Kourtis, A. P., Hatfield, K., Baggs, J., Mu, Y., See, I., Epson, E., Nadle, J., Kainer, M. A., Dumyati, G., Petit, S., et al. (2019) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6809e1 · Cited by 701 · see citing works
Jackson, K. A., Bohm, M. K., Brooks, J. T., Asher, A., Nadle, J., Bamberg, W. M., Petit, S., Ray, S. M., Harrison, L. H., Lynfield, R., et al. (2018) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6722a2 · Cited by 139 · see citing works
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Zhang, X., Li, S., Luo, H., He, S., Yang, H., Li, L., Tian, T., Han, Q., Ye, J., Huang, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01035-6 · Cited by 14 · see citing works
- Authors
- Gandhi, T. N., & Malani, P. N.
- Affiliations
- University of Michigan (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-02-11
- Volume
- 323
- Issue
- 6
- Pages
- 515
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W3005713290
- Cited by
- 14
- References
- 2
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- methicillin-resistant Staphylococcus aureus, MRSA bacteremia, combination antibiotic therapy
- MeSH terms
- Humans, Methicillin, Recurrence, Staphylococcal Infections, Vancomycin, Bacteremia, Treatment Failure, Daptomycin, beta-Lactams, Methicillin-Resistant Staphylococcus aureus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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