Cited by 88Advanced Causal Inference TechniquesStatistical Methods in Clinical TrialsMeta-analysis and systematic reviews

The DOI matches its Crossref record, with a small difference in title or year; 1 of the 1 references it cites were found in a registry or an index.

Randomized Trials vs Real-world Evidence: How Can Both Inform Decision-making?

Overview

Integrity signals

Registry

Crossref · 10.1001/jama.2023.4855

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Real-world data complement RCT data by reflecting actual use of hysterectomy and UP surgery in practice, capturing how patient and clinical factors influence surgical decisions and outcomes, and controlling for these factors with biostatistical methods.

    “Real-world data complement RCT data by reflecting actual use of hysterectomy and UP surgery in practice, capturing how patient and clinical factors influence surgical decisions and outcomes, and controlling for these factors with biostatistical methods.33,34”

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 13

  1. Wang, Emulation of randomized clinical trials with nonrandomized database analyses: results of 32 clinical trials., JAMA
  2. Rothman, 2005, Causation and causal inference in epidemiology., Am J Public Health, 95, S144, 10.2105/AJPH.2004.059204 · DOI
  3. Sackett, 1997, Evidence-based medicine., Semin Perinatol, 21, 3, 10.1016/S0146-0005(97)80013-4 · DOI
  4. Sheldrick, 2021, The debate over rational decision making in evidence-based medicine., Evid Policy, 17, 147, 10.1332/174426419X15677739896923 · DOI
  5. Lipsky, 2022, Causal directed acyclic graphs., JAMA, 327, 1083, 10.1001/jama.2022.1816 · DOI
  6. Franklin, 2020, Emulation differences versus biases when calibrating RWE findings against RCTs., Clin Pharmacol Ther, 107, 735, 10.1002/cpt.v107.4 · DOI
  7. Tversky, 1977, Features of similarity., Psychol Rev, 84, 327, 10.1037/0033-295X.84.4.327 · DOI · Paper page
  8. Christiansen, 2020, AMA Manual of Style
  9. Riegelman, 2020, Studying a Study and Testing a Test
  10. Cook, 2002, Experimental and Quasi-Experimental Designs for Generalized Causal Inference, 103
  11. Pearl, 2009, Causality, 10.1017/CBO9780511803161 · DOI · Paper page
  12. Popper, 1959, The Logic of Scientific Discovery
  13. Gilboa, 2009, Theory of Decision Under Uncertainty, 10.1017/CBO9780511840203 · DOI

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Metadata

Authors
Sheldrick, R. C.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Sheldrick, R. Christopher
Venue
JAMA
Published
2023-04-25
Volume
329
Issue
16
Pages
1352
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W4366984009
Cited by
88
References
1
Citations by year
2026: 26 · 2025: 24 · 2024: 26 · 2023: 12
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Keywords
randomized controlled trials, real-world evidence, evidence-based medicine, clinical trial limitations, observational studies
MeSH terms
Decision Making, Life Change Events, Research Design, Randomized Controlled Trials as Topic

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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