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Cited by 297

The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.

Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification

Salim Yusuf·1988·JAMA

Abstract

THIS is the second of a two-part article on the results of randomized trials of treatments designed to reduce mortality or major morbidity in heart disease. Our goal is to summarize the results of trials of common treatments on major outcomes in unstable angina, congestive heart failure, primary prevention with aspirin, and risk factor modification. This summary should provide useful background information against which clinicians must consider other information (eg, patient prognosis, risk of side effects, drug interactions, and specific clinical picture) in making decisions about individual patients. We do not deal in either article with trials of coronary artery bypass graft surgery for stable angina, trials of valve replacement, or congenital heart disease. The risk reductions are based on the odds ratio calculated by the Mantel-Haenszel method as applied to combining data from several trials. When event rates are low, the odds ratio and the relative risk are numerically

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OpenAlex · 10.1001/jama.260.15.2259

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Metadata

Authors
Yusuf, S.
Venue
JAMA
Publisher
American Medical Association
Published
1988-10-21
Volume
260
Issue
15
Pages
2259-2263
ISSN
0002-9955 (ISSN-L)
OpenAlex
W4233584339
Cited by
297
References
1
FWCI
11.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification. https://app.cochat.ai/papers/10.1001/jama.260.15.2259
The paper
Yusuf, S. (1988). Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification. JAMA. https://doi.org/10.1001/jama.260.15.2259

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.