The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous?
Abstract
We critically appraised the medical literature to evaluate whether there is a point beyond which blood pressure reduction in hypertensive subjects is no longer beneficial and possibly even deleterious. Thirteen studies that stratified cardiovascular outcomes by level of achieved blood pressure in treated hypertensive subjects who had been followed up for at least 1 year were critiqued by four independent reviewers. Data addressing population, protocol, and methodological characteristics were evaluated. Studies did not show a consistent J-shaped relationship between treated blood pressure and stroke, but they did demonstrate a consistent J-shaped relationship for cardiac events and diastolic blood pressure. The beneficial therapeutic threshold point was 85 mm Hg. We conclude that low treated diastolic blood pressure levels, ie, below 85 mm Hg, are associated with increased risk of cardiac events.
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Citations
Cites
Systolic versus diastolic blood pressure and risk of coronary heart disease
Kannel, W. B., Gordon, T., & Schwartz, M. J. (1971) · The American Journal of Cardiology · doi:10.1016/0002-9149(71)90428-0 · Cited by 925
Cited by
The use of fractional polynomials to model continuous risk variables in epidemiology
Royston, P., Ambler, G., & Sauerbrei, W. (1999) · International Journal of Epidemiology · doi:10.1093/ije/28.5.964 · Cited by 1,066
Midlife blood pressure and dementia: the Honolulu–Asia aging study☆
Launer, L. J., Ross, G. W., Petrovitch, H., Masaki, K., Foley, D., White, L. R., & Havlik, R. J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00096-8 · Cited by 1,008
Pulse pressure—a review of mechanisms and clinical relevance
Dart, A. M., & Kingwell, B. A. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01108-1 · Cited by 836
Neaton, J. D. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400130082009 · Cited by 784
Gottesman, R. F., Schneider, A. L. C., Albert, M., Alonso, A., Bandeen-Roche, K., Coker, L., Coresh, J., Knopman, D., Power, M. C., Rawlings, A., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1646 · Cited by 474
Metadata
- Authors
- Farnett, L.
- Venue
- JAMA
- Publisher
- American Medical Association
- Published
- 1991-01-23
- Volume
- 265
- Issue
- 4
- Pages
- 489-495
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W4256112597
- Cited by
- 417
- References
- 1
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Farnett, L. (1991). The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous? JAMA. https://doi.org/10.1001/jama.265.4.489
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
